Treatment of Leukocytospermia in Male Infertility: A Systematic Review
Male factors account for 20% to 50% of infertility cases, and infection in the genitourinary tract may play a contributing role in up to 15% of male infertility. Leukocytospermia is a well-known indicator of infection or inflammation in the male sex glands and the urogenital tract. Although great...
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Korean Society for Sexual Medicine and Andrology
2016-12-01
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doaj-3466a4c735434d9fa6e226bc3e6269c12020-11-24T23:52:32ZengKorean Society for Sexual Medicine and AndrologyThe World Journal of Men's Health2287-42082287-46902016-12-0134316517210.5534/wjmh.2016.34.3.165Treatment of Leukocytospermia in Male Infertility: A Systematic ReviewJae Hung Jung0Myung Ha Kim1Jiye Kim2Soon Koo Baik3Sang-Baek Koh4Hyun Jun Park5Ju Tae Seo6Yonsei Wonju Medical LibraryYonsei Wonju Medical LibraryYonsei Wonju Medical LibraryYonsei Wonju Medical LibraryYonsei Wonju Medical LibraryPusan National University School of MedicineCheil General Hospital and Women's Healthcare CenterMale factors account for 20% to 50% of infertility cases, and infection in the genitourinary tract may play a contributing role in up to 15% of male infertility. Leukocytospermia is a well-known indicator of infection or inflammation in the male sex glands and the urogenital tract. Although great deal of effort has been expended to elucidate definite management strategies in infertile men with leukocytospermia, the gold standard of treatment remains unclear. Until recently, broad spectrum antibiotics and antioxidants have been used in the treatment of leukocytospermia for male infertility to eliminate infection and reduce reactive oxygen free radicals produced inside cellular mitochondria as a result of inflammation. The present review reveals that antibiotics might improve sperm parameters, the rate of resolution of leukocytospermia, the bacteriologic cure rate, and even the pregnancy rate, although some reports conflict. Antioxidants might also have clinical benefits for sperm function as shown by in vitro studies. However, the data are insufficient to conclude whether antibiotics and antioxidants for the treatment of infertile men with leukocytospermia are effective or not. Better designed investigations into leukocytospermia are needed.https://www.wjmh.org/Synapse/Data/PDFData/2074WJMH/wjmh-34-165.pdfInfertilitymaleLeukocyteSemen analysisTherapeutics |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jae Hung Jung Myung Ha Kim Jiye Kim Soon Koo Baik Sang-Baek Koh Hyun Jun Park Ju Tae Seo |
spellingShingle |
Jae Hung Jung Myung Ha Kim Jiye Kim Soon Koo Baik Sang-Baek Koh Hyun Jun Park Ju Tae Seo Treatment of Leukocytospermia in Male Infertility: A Systematic Review The World Journal of Men's Health Infertility male Leukocyte Semen analysis Therapeutics |
author_facet |
Jae Hung Jung Myung Ha Kim Jiye Kim Soon Koo Baik Sang-Baek Koh Hyun Jun Park Ju Tae Seo |
author_sort |
Jae Hung Jung |
title |
Treatment of Leukocytospermia in Male Infertility: A Systematic Review |
title_short |
Treatment of Leukocytospermia in Male Infertility: A Systematic Review |
title_full |
Treatment of Leukocytospermia in Male Infertility: A Systematic Review |
title_fullStr |
Treatment of Leukocytospermia in Male Infertility: A Systematic Review |
title_full_unstemmed |
Treatment of Leukocytospermia in Male Infertility: A Systematic Review |
title_sort |
treatment of leukocytospermia in male infertility: a systematic review |
publisher |
Korean Society for Sexual Medicine and Andrology |
series |
The World Journal of Men's Health |
issn |
2287-4208 2287-4690 |
publishDate |
2016-12-01 |
description |
Male factors account for 20% to 50% of infertility cases, and infection in the genitourinary tract may play a contributing role in
up to 15% of male infertility. Leukocytospermia is a well-known indicator of infection or inflammation in the male sex glands and
the urogenital tract. Although great deal of effort has been expended to elucidate definite management strategies in infertile men
with leukocytospermia, the gold standard of treatment remains unclear. Until recently, broad spectrum antibiotics and
antioxidants have been used in the treatment of leukocytospermia for male infertility to eliminate infection and reduce reactive
oxygen free radicals produced inside cellular mitochondria as a result of inflammation. The present review reveals that antibiotics
might improve sperm parameters, the rate of resolution of leukocytospermia, the bacteriologic cure rate, and even the pregnancy
rate, although some reports conflict. Antioxidants might also have clinical benefits for sperm function as shown by in vitro studies.
However, the data are insufficient to conclude whether antibiotics and antioxidants for the treatment of infertile men with
leukocytospermia are effective or not. Better designed investigations into leukocytospermia are needed. |
topic |
Infertility male Leukocyte Semen analysis Therapeutics |
url |
https://www.wjmh.org/Synapse/Data/PDFData/2074WJMH/wjmh-34-165.pdf |
work_keys_str_mv |
AT jaehungjung treatmentofleukocytospermiainmaleinfertilityasystematicreview AT myunghakim treatmentofleukocytospermiainmaleinfertilityasystematicreview AT jiyekim treatmentofleukocytospermiainmaleinfertilityasystematicreview AT soonkoobaik treatmentofleukocytospermiainmaleinfertilityasystematicreview AT sangbaekkoh treatmentofleukocytospermiainmaleinfertilityasystematicreview AT hyunjunpark treatmentofleukocytospermiainmaleinfertilityasystematicreview AT jutaeseo treatmentofleukocytospermiainmaleinfertilityasystematicreview |
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