Lsd1 regulates skeletal muscle regeneration and directs the fate of satellite cells

Lsd1 regulates skeletal muscle regeneration and directs the fate of satellite cells

Satellite cells can differentiate both into myocytes and brown adipocytes. Here, the authors show that the histone demethylase Lsd1 prevents adipogenic differentiation of satellite cells by repressing expression of Glis1, and that its ablation changes satellite cell fate towards brown adipocytes and...

Full description

Bibliographic Details
Main Authors: Milica Tosic, Anita Allen, Dominica Willmann, Christoph Lepper, Johnny Kim, Delphine Duteil, Roland Schüle
Format: Article
Language:English
Published: Nature Publishing Group 2018-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-02740-5
id doaj-3468bea8b20d48ef8bf865d12864b2d3
record_format Article
spelling doaj-3468bea8b20d48ef8bf865d12864b2d32021-05-11T10:11:34ZengNature Publishing GroupNature Communications2041-17232018-01-019111410.1038/s41467-017-02740-5Lsd1 regulates skeletal muscle regeneration and directs the fate of satellite cellsMilica Tosic0Anita Allen1Dominica Willmann2Christoph Lepper3Johnny Kim4Delphine Duteil5Roland Schüle6Urologische Klinik und Zentrale Klinische Forschung, Universitätsklinikum Freiburg, Medizinische Fakultät, Albert-Ludwigs-University FreiburgUrologische Klinik und Zentrale Klinische Forschung, Universitätsklinikum Freiburg, Medizinische Fakultät, Albert-Ludwigs-University FreiburgUrologische Klinik und Zentrale Klinische Forschung, Universitätsklinikum Freiburg, Medizinische Fakultät, Albert-Ludwigs-University FreiburgDepartment of Embryology, Carnegie InstitutionDepartment of Cardiac Development and Remodeling, Max Planck Institute for Heart and Lung ResearchUrologische Klinik und Zentrale Klinische Forschung, Universitätsklinikum Freiburg, Medizinische Fakultät, Albert-Ludwigs-University FreiburgUrologische Klinik und Zentrale Klinische Forschung, Universitätsklinikum Freiburg, Medizinische Fakultät, Albert-Ludwigs-University FreiburgSatellite cells can differentiate both into myocytes and brown adipocytes. Here, the authors show that the histone demethylase Lsd1 prevents adipogenic differentiation of satellite cells by repressing expression of Glis1, and that its ablation changes satellite cell fate towards brown adipocytes and delays muscle regeneration in mice.https://doi.org/10.1038/s41467-017-02740-5
collection DOAJ
language English
format Article
sources DOAJ
author Milica Tosic
Anita Allen
Dominica Willmann
Christoph Lepper
Johnny Kim
Delphine Duteil
Roland Schüle
spellingShingle Milica Tosic
Anita Allen
Dominica Willmann
Christoph Lepper
Johnny Kim
Delphine Duteil
Roland Schüle
Lsd1 regulates skeletal muscle regeneration and directs the fate of satellite cells
Nature Communications
author_facet Milica Tosic
Anita Allen
Dominica Willmann
Christoph Lepper
Johnny Kim
Delphine Duteil
Roland Schüle
author_sort Milica Tosic
title Lsd1 regulates skeletal muscle regeneration and directs the fate of satellite cells
title_short Lsd1 regulates skeletal muscle regeneration and directs the fate of satellite cells
title_full Lsd1 regulates skeletal muscle regeneration and directs the fate of satellite cells
title_fullStr Lsd1 regulates skeletal muscle regeneration and directs the fate of satellite cells
title_full_unstemmed Lsd1 regulates skeletal muscle regeneration and directs the fate of satellite cells
title_sort lsd1 regulates skeletal muscle regeneration and directs the fate of satellite cells
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2018-01-01
description Satellite cells can differentiate both into myocytes and brown adipocytes. Here, the authors show that the histone demethylase Lsd1 prevents adipogenic differentiation of satellite cells by repressing expression of Glis1, and that its ablation changes satellite cell fate towards brown adipocytes and delays muscle regeneration in mice.
url https://doi.org/10.1038/s41467-017-02740-5
work_keys_str_mv AT milicatosic lsd1regulatesskeletalmuscleregenerationanddirectsthefateofsatellitecells
AT anitaallen lsd1regulatesskeletalmuscleregenerationanddirectsthefateofsatellitecells
AT dominicawillmann lsd1regulatesskeletalmuscleregenerationanddirectsthefateofsatellitecells
AT christophlepper lsd1regulatesskeletalmuscleregenerationanddirectsthefateofsatellitecells
AT johnnykim lsd1regulatesskeletalmuscleregenerationanddirectsthefateofsatellitecells
AT delphineduteil lsd1regulatesskeletalmuscleregenerationanddirectsthefateofsatellitecells
AT rolandschule lsd1regulatesskeletalmuscleregenerationanddirectsthefateofsatellitecells
_version_ 1721448593612603392

Similar Items