Human CCL3L1 copy number variation, gene expression, and the role of the CCL3L1-CCR5 axis in lung function [version 1; referees: 2 approved]

Human CCL3L1 copy number variation, gene expression, and the role of the CCL3L1-CCR5 axis in lung function [version 1; referees: 2 approved]

Background: The CCL3L1-CCR5 signaling axis is important in a number of inflammatory responses, including macrophage function, and T-cell-dependent immune responses. Small molecule CCR5 antagonists exist, including the approved antiretroviral drug maraviroc, and therapeutic monoclonal antibodies are...

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Bibliographic Details
Main Authors: Adeolu B. Adewoye, Nick Shrine, Linda Odenthal-Hesse, Samantha Welsh, Anders Malarstig, Scott Jelinsky, Iain Kilty, Martin D. Tobin, Edward J. Hollox, Louise V. Wain
Format: Article
Language:English
Published: Wellcome 2018-02-01
Series:Wellcome Open Research
Online Access:https://wellcomeopenresearch.org/articles/3-13/v1

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