Nephron progenitor commitment is a stochastic process influenced by cell migration

Nephron progenitor commitment is a stochastic process influenced by cell migration

Progenitor self-renewal and differentiation is often regulated by spatially restricted cues within a tissue microenvironment. Here, we examine how progenitor cell migration impacts regionally induced commitment within the nephrogenic niche in mice. We identify a subset of cells that express Wnt4, an...

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Bibliographic Details
Main Authors: Kynan T Lawlor, Luke Zappia, James Lefevre, Joo-Seop Park, Nicholas A Hamilton, Alicia Oshlack, Melissa H Little, Alexander N Combes
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-01-01
Series:eLife
Subjects:
kidney development
nephron progenitor
cell migration
single cell transcriptional profiling
Wnt4
stochastic induction
Online Access:https://elifesciences.org/articles/41156

Internet

https://elifesciences.org/articles/41156

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