Lower mutation frequency of BCP/precore regions in e antigen-negative chronic HBV-infected children instead of adults patients.
To describe the Hepatitis B e antigen(HBeAg) seroconversion related mutation profiles of the basal core promoter(BCP)/precore regions in e antigen seroconverted child patients, a cohort of 245 child patients with CHB and a control patients group of 92 adult patients with CHB were recruited. The muta...
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doaj-348400bceff94a5087d099c3c59d0d432021-03-03T20:07:09ZengPublic Library of Science (PLoS)PLoS ONE1932-62032015-01-01103e012073310.1371/journal.pone.0120733Lower mutation frequency of BCP/precore regions in e antigen-negative chronic HBV-infected children instead of adults patients.Yong HuangHaijun DengXuefeng ShanXuyang GongXiaosong LiZen TuQuanxin LongAilong HuangTo describe the Hepatitis B e antigen(HBeAg) seroconversion related mutation profiles of the basal core promoter(BCP)/precore regions in e antigen seroconverted child patients, a cohort of 245 child patients with CHB and a control patients group of 92 adult patients with CHB were recruited. The mutation frequencies of six nucleotides or nucleotide combinations including nucleotide (nt)1896, nt1762/1764, nt1752, nt1846, nt1899 and nt1753 showed significant differences between HBeAg positive and HBeAg-negative child patients groups. The frequencies of these HBeAg seroconversion-related mutations were significantly lower in HBeAg-negative children with CHB than in HBeAg-negative adults with CHB, especially for the mutation G1896A (41.1% vs 91.7%, P<0.001), and the average number of BCP/precore region mutations in samples from HBeAg-negative child patients was also obviously lower than in HBeAg-negative adult patients(3.62±3.03 vs 4.89±2.09, P<0.001), suggesting less impact of mutations in the BCP/precore region on HBeAg seroconversion in child patients than adult patients.https://doi.org/10.1371/journal.pone.0120733 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yong Huang Haijun Deng Xuefeng Shan Xuyang Gong Xiaosong Li Zen Tu Quanxin Long Ailong Huang |
spellingShingle |
Yong Huang Haijun Deng Xuefeng Shan Xuyang Gong Xiaosong Li Zen Tu Quanxin Long Ailong Huang Lower mutation frequency of BCP/precore regions in e antigen-negative chronic HBV-infected children instead of adults patients. PLoS ONE |
author_facet |
Yong Huang Haijun Deng Xuefeng Shan Xuyang Gong Xiaosong Li Zen Tu Quanxin Long Ailong Huang |
author_sort |
Yong Huang |
title |
Lower mutation frequency of BCP/precore regions in e antigen-negative chronic HBV-infected children instead of adults patients. |
title_short |
Lower mutation frequency of BCP/precore regions in e antigen-negative chronic HBV-infected children instead of adults patients. |
title_full |
Lower mutation frequency of BCP/precore regions in e antigen-negative chronic HBV-infected children instead of adults patients. |
title_fullStr |
Lower mutation frequency of BCP/precore regions in e antigen-negative chronic HBV-infected children instead of adults patients. |
title_full_unstemmed |
Lower mutation frequency of BCP/precore regions in e antigen-negative chronic HBV-infected children instead of adults patients. |
title_sort |
lower mutation frequency of bcp/precore regions in e antigen-negative chronic hbv-infected children instead of adults patients. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2015-01-01 |
description |
To describe the Hepatitis B e antigen(HBeAg) seroconversion related mutation profiles of the basal core promoter(BCP)/precore regions in e antigen seroconverted child patients, a cohort of 245 child patients with CHB and a control patients group of 92 adult patients with CHB were recruited. The mutation frequencies of six nucleotides or nucleotide combinations including nucleotide (nt)1896, nt1762/1764, nt1752, nt1846, nt1899 and nt1753 showed significant differences between HBeAg positive and HBeAg-negative child patients groups. The frequencies of these HBeAg seroconversion-related mutations were significantly lower in HBeAg-negative children with CHB than in HBeAg-negative adults with CHB, especially for the mutation G1896A (41.1% vs 91.7%, P<0.001), and the average number of BCP/precore region mutations in samples from HBeAg-negative child patients was also obviously lower than in HBeAg-negative adult patients(3.62±3.03 vs 4.89±2.09, P<0.001), suggesting less impact of mutations in the BCP/precore region on HBeAg seroconversion in child patients than adult patients. |
url |
https://doi.org/10.1371/journal.pone.0120733 |
work_keys_str_mv |
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