Prognostic impact of p53, c-erbB-2 and epidermal growth factor receptor on head and neck carcinoma
CONTEXT: p53, c-erbB-2 and epidermal growth factor receptor (EGFR) are cancer-related proteins that are usually expressed in head and neck squamous cell carcinoma (SCC). Their prognostic value remains controversial. OBJECTIVE: To evaluate the prognostic impact of p53, c-erbB-2 and EGFR expression in...
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doaj-3487bc8cdf7c4ddd8f6574c2a67a9fa62020-11-24T22:36:24ZengAssociação Paulista de MedicinaSão Paulo Medical Journal1806-9460122626426810.1590/S1516-31802004000600007S1516-31802004000600007Prognostic impact of p53, c-erbB-2 and epidermal growth factor receptor on head and neck carcinomaOrlando Parise Junior0Leda Viegas Carvalho1Roberto Elias Villela Miguel2Luiz Paulo Kowalski3Hospital Sírio-LibanêsLusiada FoundationHospital Sírio-LibanêsHospital A. C. CamargoCONTEXT: p53, c-erbB-2 and epidermal growth factor receptor (EGFR) are cancer-related proteins that are usually expressed in head and neck squamous cell carcinoma (SCC). Their prognostic value remains controversial. OBJECTIVE: To evaluate the prognostic impact of p53, c-erbB-2 and EGFR expression in head and neck SCC. TYPE OF STUDY: Prospective. SETTING: Head and Neck Surgery Department, Hospital AC Camargo, São Paulo. METHODS: Fifty-four patients were studied for p53, c-erbB-2 and EGFR expression in head and neck SCC and adjacent mucosa, via immunohistochemistry. These data were correlated with histoclinical data and survival. RESULTS: There was a direct association of p53 expression in SCC and mucosa (p = 0.001); loss of c-erbB-2 expression (-) from normal mucosa to SCC (p = 0.04); lower frequency of association of c-erbB-2 (+) with EGFR (-) in SCC (p = 0.02); and a direct association of EGFR (+) expression in SCC and mitotic index (p = 0.03). The 60-month actuarial survival rates for patients presenting lymph node metastasis were higher when there was no capsule rupture by SCC (48.3%; p = 0.02), no more than one positive lymph node (52.3%; p = 0.004) or clear surgical margins (47.0%; p = 0.01), in comparison with patients presenting capsule rupture (20.2%), two or more positive lymph nodes (18.7%) or compromised surgical margins (0.0%), respectively. Patients presenting SCC p53 (+) and EGFR (-) demonstrated greater survival (75.0%; p = 0.03) than for the remaining group (33.1%). Multivariate analysis confirmed the positive impact of p53 (+) and EGFR (-) on survival (p = 0.02). DISCUSSION: Associations were found for p53, c-erbB-2 and EGFR expression with histoclinical data and prognosis. Interestingly, these results suggest that loss of mucosal c-erbB-2 expression could be involved in SCC carcinogenesis; EGFR expression in SCC is related to tumor mitotic index; and presence of p53 with absence of EGFR expression in head and neck SCC may be a prognostic factor for survival. CONCLUSIONS: Further prospective studies should be conducted to confirm the influence of p53, c-erbB-2 and EGFR on histoclinical data and prognosis.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802004000600007&lng=en&tlng=enSquamous cell carcinomaGenes p53Genes c-erbB-2Protein p53Protein c-erbB-2 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Orlando Parise Junior Leda Viegas Carvalho Roberto Elias Villela Miguel Luiz Paulo Kowalski |
spellingShingle |
Orlando Parise Junior Leda Viegas Carvalho Roberto Elias Villela Miguel Luiz Paulo Kowalski Prognostic impact of p53, c-erbB-2 and epidermal growth factor receptor on head and neck carcinoma São Paulo Medical Journal Squamous cell carcinoma Genes p53 Genes c-erbB-2 Protein p53 Protein c-erbB-2 |
author_facet |
Orlando Parise Junior Leda Viegas Carvalho Roberto Elias Villela Miguel Luiz Paulo Kowalski |
author_sort |
Orlando Parise Junior |
title |
Prognostic impact of p53, c-erbB-2 and epidermal growth factor receptor on head and neck carcinoma |
title_short |
Prognostic impact of p53, c-erbB-2 and epidermal growth factor receptor on head and neck carcinoma |
title_full |
Prognostic impact of p53, c-erbB-2 and epidermal growth factor receptor on head and neck carcinoma |
title_fullStr |
Prognostic impact of p53, c-erbB-2 and epidermal growth factor receptor on head and neck carcinoma |
title_full_unstemmed |
Prognostic impact of p53, c-erbB-2 and epidermal growth factor receptor on head and neck carcinoma |
title_sort |
prognostic impact of p53, c-erbb-2 and epidermal growth factor receptor on head and neck carcinoma |
publisher |
Associação Paulista de Medicina |
series |
São Paulo Medical Journal |
issn |
1806-9460 |
description |
CONTEXT: p53, c-erbB-2 and epidermal growth factor receptor (EGFR) are cancer-related proteins that are usually expressed in head and neck squamous cell carcinoma (SCC). Their prognostic value remains controversial. OBJECTIVE: To evaluate the prognostic impact of p53, c-erbB-2 and EGFR expression in head and neck SCC. TYPE OF STUDY: Prospective. SETTING: Head and Neck Surgery Department, Hospital AC Camargo, São Paulo. METHODS: Fifty-four patients were studied for p53, c-erbB-2 and EGFR expression in head and neck SCC and adjacent mucosa, via immunohistochemistry. These data were correlated with histoclinical data and survival. RESULTS: There was a direct association of p53 expression in SCC and mucosa (p = 0.001); loss of c-erbB-2 expression (-) from normal mucosa to SCC (p = 0.04); lower frequency of association of c-erbB-2 (+) with EGFR (-) in SCC (p = 0.02); and a direct association of EGFR (+) expression in SCC and mitotic index (p = 0.03). The 60-month actuarial survival rates for patients presenting lymph node metastasis were higher when there was no capsule rupture by SCC (48.3%; p = 0.02), no more than one positive lymph node (52.3%; p = 0.004) or clear surgical margins (47.0%; p = 0.01), in comparison with patients presenting capsule rupture (20.2%), two or more positive lymph nodes (18.7%) or compromised surgical margins (0.0%), respectively. Patients presenting SCC p53 (+) and EGFR (-) demonstrated greater survival (75.0%; p = 0.03) than for the remaining group (33.1%). Multivariate analysis confirmed the positive impact of p53 (+) and EGFR (-) on survival (p = 0.02). DISCUSSION: Associations were found for p53, c-erbB-2 and EGFR expression with histoclinical data and prognosis. Interestingly, these results suggest that loss of mucosal c-erbB-2 expression could be involved in SCC carcinogenesis; EGFR expression in SCC is related to tumor mitotic index; and presence of p53 with absence of EGFR expression in head and neck SCC may be a prognostic factor for survival. CONCLUSIONS: Further prospective studies should be conducted to confirm the influence of p53, c-erbB-2 and EGFR on histoclinical data and prognosis. |
topic |
Squamous cell carcinoma Genes p53 Genes c-erbB-2 Protein p53 Protein c-erbB-2 |
url |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802004000600007&lng=en&tlng=en |
work_keys_str_mv |
AT orlandoparisejunior prognosticimpactofp53cerbb2andepidermalgrowthfactorreceptoronheadandneckcarcinoma AT ledaviegascarvalho prognosticimpactofp53cerbb2andepidermalgrowthfactorreceptoronheadandneckcarcinoma AT robertoeliasvillelamiguel prognosticimpactofp53cerbb2andepidermalgrowthfactorreceptoronheadandneckcarcinoma AT luizpaulokowalski prognosticimpactofp53cerbb2andepidermalgrowthfactorreceptoronheadandneckcarcinoma |
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