Long-Term Effects of Nilvadipine against Progression of the Central Visual Field Defect in Retinitis Pigmentosa: An Extended Study
Purpose. To assess the long-term effects of nilvadipine on the progression of central visual field defect in retinitis pigmentosa (RP). Methods. Patients with RP were randomly divided into a treated group receiving oral nilvadipine and a control group. Progression of RP was evaluated with MD slope a...
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doaj-349007e4e09b436bb5cd553d10e7f8fe2020-11-24T23:14:29ZengHindawi LimitedBioMed Research International2314-61332314-61412013-01-01201310.1155/2013/585729585729Long-Term Effects of Nilvadipine against Progression of the Central Visual Field Defect in Retinitis Pigmentosa: An Extended StudyMitsuru Nakazawa0Yukihiko Suzuki1Tadashi Ito2Tomomi Metoki3Takashi Kudo4Hiroshi Ohguro5Department of Ophthalmology, Hirosaki University Graduate School of Medicine, 5 Zaifu-cho, Hirosaki 036-8562, JapanDepartment of Ophthalmology, Hirosaki University Graduate School of Medicine, 5 Zaifu-cho, Hirosaki 036-8562, JapanDepartment of Ophthalmology, Hirosaki University Graduate School of Medicine, 5 Zaifu-cho, Hirosaki 036-8562, JapanDepartment of Ophthalmology, Hirosaki University Graduate School of Medicine, 5 Zaifu-cho, Hirosaki 036-8562, JapanDepartment of Ophthalmology, Hirosaki University Graduate School of Medicine, 5 Zaifu-cho, Hirosaki 036-8562, JapanDepartment of Ophthalmology, Sapporo Medical University, S1W17, Chuo-ku, Sapporo 060-8556, JapanPurpose. To assess the long-term effects of nilvadipine on the progression of central visual field defect in retinitis pigmentosa (RP). Methods. Patients with RP were randomly divided into a treated group receiving oral nilvadipine and a control group. Progression of RP was evaluated with MD slope and the average sensitivity of the central 2° (ΔCENT4). Results. The mean MD slopes were −0.55/−0.39 (right/left eyes, n=19) dB/year in the treated group and −1.37/−1.15 (right/left eyes, n=22) dB/year in the control group (P=0.016/0.050, resp.). In both eyes, however, no statistical difference was observed between the two groups for the ΔCENT4 values. Conclusion. Although we confirmed that nilvadipine significantly retarded the progression of the average of MD value defects in the central 10°, it was not specific for the central 2° of the visual field in RP.http://dx.doi.org/10.1155/2013/585729 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Mitsuru Nakazawa Yukihiko Suzuki Tadashi Ito Tomomi Metoki Takashi Kudo Hiroshi Ohguro |
spellingShingle |
Mitsuru Nakazawa Yukihiko Suzuki Tadashi Ito Tomomi Metoki Takashi Kudo Hiroshi Ohguro Long-Term Effects of Nilvadipine against Progression of the Central Visual Field Defect in Retinitis Pigmentosa: An Extended Study BioMed Research International |
author_facet |
Mitsuru Nakazawa Yukihiko Suzuki Tadashi Ito Tomomi Metoki Takashi Kudo Hiroshi Ohguro |
author_sort |
Mitsuru Nakazawa |
title |
Long-Term Effects of Nilvadipine against Progression of the Central Visual Field Defect in Retinitis Pigmentosa: An Extended Study |
title_short |
Long-Term Effects of Nilvadipine against Progression of the Central Visual Field Defect in Retinitis Pigmentosa: An Extended Study |
title_full |
Long-Term Effects of Nilvadipine against Progression of the Central Visual Field Defect in Retinitis Pigmentosa: An Extended Study |
title_fullStr |
Long-Term Effects of Nilvadipine against Progression of the Central Visual Field Defect in Retinitis Pigmentosa: An Extended Study |
title_full_unstemmed |
Long-Term Effects of Nilvadipine against Progression of the Central Visual Field Defect in Retinitis Pigmentosa: An Extended Study |
title_sort |
long-term effects of nilvadipine against progression of the central visual field defect in retinitis pigmentosa: an extended study |
publisher |
Hindawi Limited |
series |
BioMed Research International |
issn |
2314-6133 2314-6141 |
publishDate |
2013-01-01 |
description |
Purpose. To assess the long-term effects of nilvadipine on the progression of central visual field defect in retinitis pigmentosa (RP). Methods. Patients with RP were randomly divided into a treated group receiving oral nilvadipine and a control group. Progression of RP was evaluated with MD slope and the average sensitivity of the central 2° (ΔCENT4). Results. The mean MD slopes were −0.55/−0.39 (right/left eyes, n=19) dB/year in the treated group and −1.37/−1.15 (right/left eyes, n=22) dB/year in the control group (P=0.016/0.050, resp.). In both eyes, however, no statistical difference was observed between the two groups for the ΔCENT4 values. Conclusion. Although we confirmed that nilvadipine significantly retarded the progression of the average of MD value defects in the central 10°, it was not specific for the central 2° of the visual field in RP. |
url |
http://dx.doi.org/10.1155/2013/585729 |
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