Low Hypoperfusion Intensity Ratio Is Associated with a Favorable Outcome Even in Large Ischemic Core and Delayed Recanalization Time
In ischemic brain tissue, hypoperfusion severity can be assessed using the hypoperfusion intensity ratio (HIR). We evaluated the link between HIR and clinical outcomes after successful recanalization by endovascular treatment. We retrospectively reviewed 162 consecutive patients who underwent endova...
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doaj-349478b01a5d4d1b8881ecbf364f51072021-04-26T23:01:52ZengMDPI AGJournal of Clinical Medicine2077-03832021-04-01101869186910.3390/jcm10091869Low Hypoperfusion Intensity Ratio Is Associated with a Favorable Outcome Even in Large Ischemic Core and Delayed Recanalization TimeJang-Hyun Baek0Young Dae Kim1Ki Jeong Lee2Jin Kyo Choi3Minyoul Baik4Byung Moon Kim5Dong Joon Kim6Ji Hoe Heo7Hyo Suk Nam8Department of Neurology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul 10415, KoreaDepartment of Neurology, Severance Hospital, Yonsei University College of Medicine, Seoul 03722, KoreaDepartment of Neurology, Severance Hospital, Yonsei University College of Medicine, Seoul 03722, KoreaDepartment of Neurology, Severance Hospital, Yonsei University College of Medicine, Seoul 03722, KoreaDepartment of Neurology, Severance Hospital, Yonsei University College of Medicine, Seoul 03722, KoreaDepartment of Radiology, Severance Hospital, Yonsei University College of Medicine, Seoul 03722, KoreaDepartment of Radiology, Severance Hospital, Yonsei University College of Medicine, Seoul 03722, KoreaDepartment of Neurology, Severance Hospital, Yonsei University College of Medicine, Seoul 03722, KoreaDepartment of Neurology, Severance Hospital, Yonsei University College of Medicine, Seoul 03722, KoreaIn ischemic brain tissue, hypoperfusion severity can be assessed using the hypoperfusion intensity ratio (HIR). We evaluated the link between HIR and clinical outcomes after successful recanalization by endovascular treatment. We retrospectively reviewed 162 consecutive patients who underwent endovascular treatment for intracranial large vessel occlusion. The HIR was calculated using an automated software program, with initial computed tomography perfusion images. The HIR was compared between patients with and without favorable outcomes. To observe the modifying effect of the HIR on the well-known major outcome determinants, regression analyses were performed in the low and high HIR groups. The median HIR value was significantly lower in patients with a favorable outcome, with an optimal cut-off point of 0.54. The HIR was an independent factor for a favorable outcome in a specific multivariable model and was significantly correlated with the Alberta Stroke Program Early Computed Tomography Score (ASPECTS). In contrast to the high HIR group, the low HIR group showed that ASPECTS and onset-to-recanalization time were not independently associated with a favorable outcome. Finally, the low HIR group had a more favorable outcome even in cases with an unfavorable ASPECTS and onset-to-recanalization time. The HIR could be useful in predicting outcomes after successful recanalization.https://www.mdpi.com/2077-0383/10/9/1869hypoperfusioncollateralitystrokeoutcomethrombectomy |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jang-Hyun Baek Young Dae Kim Ki Jeong Lee Jin Kyo Choi Minyoul Baik Byung Moon Kim Dong Joon Kim Ji Hoe Heo Hyo Suk Nam |
spellingShingle |
Jang-Hyun Baek Young Dae Kim Ki Jeong Lee Jin Kyo Choi Minyoul Baik Byung Moon Kim Dong Joon Kim Ji Hoe Heo Hyo Suk Nam Low Hypoperfusion Intensity Ratio Is Associated with a Favorable Outcome Even in Large Ischemic Core and Delayed Recanalization Time Journal of Clinical Medicine hypoperfusion collaterality stroke outcome thrombectomy |
author_facet |
Jang-Hyun Baek Young Dae Kim Ki Jeong Lee Jin Kyo Choi Minyoul Baik Byung Moon Kim Dong Joon Kim Ji Hoe Heo Hyo Suk Nam |
author_sort |
Jang-Hyun Baek |
title |
Low Hypoperfusion Intensity Ratio Is Associated with a Favorable Outcome Even in Large Ischemic Core and Delayed Recanalization Time |
title_short |
Low Hypoperfusion Intensity Ratio Is Associated with a Favorable Outcome Even in Large Ischemic Core and Delayed Recanalization Time |
title_full |
Low Hypoperfusion Intensity Ratio Is Associated with a Favorable Outcome Even in Large Ischemic Core and Delayed Recanalization Time |
title_fullStr |
Low Hypoperfusion Intensity Ratio Is Associated with a Favorable Outcome Even in Large Ischemic Core and Delayed Recanalization Time |
title_full_unstemmed |
Low Hypoperfusion Intensity Ratio Is Associated with a Favorable Outcome Even in Large Ischemic Core and Delayed Recanalization Time |
title_sort |
low hypoperfusion intensity ratio is associated with a favorable outcome even in large ischemic core and delayed recanalization time |
publisher |
MDPI AG |
series |
Journal of Clinical Medicine |
issn |
2077-0383 |
publishDate |
2021-04-01 |
description |
In ischemic brain tissue, hypoperfusion severity can be assessed using the hypoperfusion intensity ratio (HIR). We evaluated the link between HIR and clinical outcomes after successful recanalization by endovascular treatment. We retrospectively reviewed 162 consecutive patients who underwent endovascular treatment for intracranial large vessel occlusion. The HIR was calculated using an automated software program, with initial computed tomography perfusion images. The HIR was compared between patients with and without favorable outcomes. To observe the modifying effect of the HIR on the well-known major outcome determinants, regression analyses were performed in the low and high HIR groups. The median HIR value was significantly lower in patients with a favorable outcome, with an optimal cut-off point of 0.54. The HIR was an independent factor for a favorable outcome in a specific multivariable model and was significantly correlated with the Alberta Stroke Program Early Computed Tomography Score (ASPECTS). In contrast to the high HIR group, the low HIR group showed that ASPECTS and onset-to-recanalization time were not independently associated with a favorable outcome. Finally, the low HIR group had a more favorable outcome even in cases with an unfavorable ASPECTS and onset-to-recanalization time. The HIR could be useful in predicting outcomes after successful recanalization. |
topic |
hypoperfusion collaterality stroke outcome thrombectomy |
url |
https://www.mdpi.com/2077-0383/10/9/1869 |
work_keys_str_mv |
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