Prevalence of primary infertility caused by chromosomal abnormalities and assessment of clinical manifestations in Rwandan patients
INTRODUCTION: Infertility affects millions of couples worldwide causing psycho-social problems and conflicts in families. Despite the establishment of multiple causes of infertility in both males and females, there have been no studies carried out in Rwanda about primary infertility caused by chro...
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doaj-3498d89fef684772888d16502078b5462020-11-25T03:49:58ZengRwanda Biomedical Centre (RBC)/Rwanda Health Communication CenterRwanda Medical Journal2079-097X2410-86262020-03-017712327Prevalence of primary infertility caused by chromosomal abnormalities and assessment of clinical manifestations in Rwandan patientsB. Mvuyekure0C. Mutoni1E. A. Murinzi2W. Ngizwenayo3C. Nsanzabaganwa4https://orcid.org/0000-0002-0245-604XL. Mutesa5School of Medicine and Health Sciences; University of RwandaSchool of Medicine and Health Sciences; University of RwandaSchool of Medicine and Health Sciences; University of RwandaSchool of Medicine and Health Sciences; University of RwandaRwanda Military Hospital, Kigali, RwandaSchool of Medicine and Health Sciences; University of RwandaINTRODUCTION: Infertility affects millions of couples worldwide causing psycho-social problems and conflicts in families. Despite the establishment of multiple causes of infertility in both males and females, there have been no studies carried out in Rwanda about primary infertility caused by chromosomal abnormalities. Thus, the aim of this study is to determine the prevalence of primary infertility caused by chromosomal abnormalities and to assess the clinical manifestations in Rwandan patients. METHODS: We performed a cross-sectional retrospective assessment of the data extracted from medical files and OpenClinic (an electronic data recording system) of patients transferred to one genetic lab in Huye that works with three main referral hospitals: Kigali University Teaching Hospital (CHUK), Huye University Teaching Hospital (CHUB) and Rwanda Military Hospital (RMH) from June 2009 to June 2019. RESULTS: This study showed that the overall prevalence of primary infertility caused by chromosomal abnormalities was 25.4% (N=15/59) among the patients who consulted the genetic department. Females were more affected than males with 32% (N=8/25) of females being primarily infertile due to chromosomal abnormalities and 20.58% (N=7/34) of males respectively. Our study also found that the majority (66.1%) of infertile patients had a normal karyotype in both genders with 40.7% of the males (46, XY) and 25.4% of the females (46,XX). CONCLUSION: Chromosomal abnormalities contribute significantly to primary infertility in the Rwandan population. Thus, clinicians should consider these chromosomal abnormalities in patients attending fertility clinics.https://www.rwandamedicaljournal.org/uploads/1/2/2/1/122149944/op.19.54.pdfinfertilityprimarychromosomal abnormalitiesprevalencerwanda |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
B. Mvuyekure C. Mutoni E. A. Murinzi W. Ngizwenayo C. Nsanzabaganwa L. Mutesa |
spellingShingle |
B. Mvuyekure C. Mutoni E. A. Murinzi W. Ngizwenayo C. Nsanzabaganwa L. Mutesa Prevalence of primary infertility caused by chromosomal abnormalities and assessment of clinical manifestations in Rwandan patients Rwanda Medical Journal infertility primary chromosomal abnormalities prevalence rwanda |
author_facet |
B. Mvuyekure C. Mutoni E. A. Murinzi W. Ngizwenayo C. Nsanzabaganwa L. Mutesa |
author_sort |
B. Mvuyekure |
title |
Prevalence of primary infertility caused by chromosomal abnormalities and assessment of clinical manifestations in Rwandan patients |
title_short |
Prevalence of primary infertility caused by chromosomal abnormalities and assessment of clinical manifestations in Rwandan patients |
title_full |
Prevalence of primary infertility caused by chromosomal abnormalities and assessment of clinical manifestations in Rwandan patients |
title_fullStr |
Prevalence of primary infertility caused by chromosomal abnormalities and assessment of clinical manifestations in Rwandan patients |
title_full_unstemmed |
Prevalence of primary infertility caused by chromosomal abnormalities and assessment of clinical manifestations in Rwandan patients |
title_sort |
prevalence of primary infertility caused by chromosomal abnormalities and assessment of clinical manifestations in rwandan patients |
publisher |
Rwanda Biomedical Centre (RBC)/Rwanda Health Communication Center |
series |
Rwanda Medical Journal |
issn |
2079-097X 2410-8626 |
publishDate |
2020-03-01 |
description |
INTRODUCTION: Infertility affects millions of couples worldwide causing psycho-social problems and conflicts in families.
Despite the establishment of multiple causes of infertility in both males and females, there have been no studies carried out
in Rwanda about primary infertility caused by chromosomal abnormalities. Thus, the aim of this study is to determine the
prevalence of primary infertility caused by chromosomal abnormalities and to assess the clinical manifestations in Rwandan
patients.
METHODS: We performed a cross-sectional retrospective assessment of the data extracted from medical files and OpenClinic
(an electronic data recording system) of patients transferred to one genetic lab in Huye that works with three main referral
hospitals: Kigali University Teaching Hospital (CHUK), Huye University Teaching Hospital (CHUB) and Rwanda Military Hospital
(RMH) from June 2009 to June 2019.
RESULTS: This study showed that the overall prevalence of primary infertility caused by chromosomal abnormalities was
25.4% (N=15/59) among the patients who consulted the genetic department. Females were more affected than males with
32% (N=8/25) of females being primarily infertile due to chromosomal abnormalities and 20.58% (N=7/34) of males respectively.
Our study also found that the majority (66.1%) of infertile patients had a normal karyotype in both genders with 40.7%
of the males (46, XY) and 25.4% of the females (46,XX).
CONCLUSION: Chromosomal abnormalities contribute significantly to primary infertility in the Rwandan population. Thus,
clinicians should consider these chromosomal abnormalities in patients attending fertility clinics. |
topic |
infertility primary chromosomal abnormalities prevalence rwanda |
url |
https://www.rwandamedicaljournal.org/uploads/1/2/2/1/122149944/op.19.54.pdf |
work_keys_str_mv |
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