The impact of maternal and early life malnutrition on health: a diet-microbe perspective
Abstract Background Early-life malnutrition may have long-lasting effects on microbe-host interactions that affect health and disease susceptibility later in life. Diet quality and quantity in conjunction with toxin and pathogen exposure are key contributors to microbe-host physiology and malnutriti...
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doaj-3499ab4be36143f28a46e122ba26d2602020-11-25T02:14:58ZengBMCBMC Medicine1741-70152020-05-0118111510.1186/s12916-020-01584-zThe impact of maternal and early life malnutrition on health: a diet-microbe perspectiveAndrew J. Forgie0Kelsea M. Drall1Stephane L. Bourque2Catherine J. Field3Anita L. Kozyrskyj4Benjamin P. Willing5Department of Agricultural, Food and Nutritional Science, University of AlbertaDepartment of Pediatrics, University of AlbertaDepartment of Anesthesiology & Pain Medicine, University of AlbertaDepartment of Agricultural, Food and Nutritional Science, University of AlbertaDepartment of Pediatrics, University of AlbertaDepartment of Agricultural, Food and Nutritional Science, University of AlbertaAbstract Background Early-life malnutrition may have long-lasting effects on microbe-host interactions that affect health and disease susceptibility later in life. Diet quality and quantity in conjunction with toxin and pathogen exposure are key contributors to microbe-host physiology and malnutrition. Consequently, it is important to consider both diet- and microbe-induced pathologies as well as their interactions underlying malnutrition. Main Body Gastrointestinal immunity and digestive function are vital to maintain a symbiotic relationship between the host and microbiota. Childhood malnutrition can be impacted by numerous factors including gestational malnutrition, early life antibiotic use, psychological stress, food allergy, hygiene, and exposure to other chemicals and pollutants. These factors can contribute to reoccurring environmental enteropathy, a condition characterized by the expansion of commensal pathobionts and environmental pathogens. Reoccurring intestinal dysfunction, particularly during the critical window of development, may be a consequence of diet-microbe interactions and may lead to life-long immune and metabolic programming and increased disease risk. We provide an overview of the some key factors implicated in the progression of malnutrition (protein, fat, carbohydrate, iron, vitamin D, and vitamin B12) and discuss the microbiota during early life that may contribute health risk later in life. Conclusion Identifying key microbe-host interactions, particularly those associated with diet and malnutrition requires well-controlled dietary studies. Furthering our understanding of diet-microbe-host interactions will help to provide better strategies during gestation and early life to promote health later in life.http://link.springer.com/article/10.1186/s12916-020-01584-zUndernutritionMalnutritionDietMicrobiomeGastrointestinalDisease |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Andrew J. Forgie Kelsea M. Drall Stephane L. Bourque Catherine J. Field Anita L. Kozyrskyj Benjamin P. Willing |
spellingShingle |
Andrew J. Forgie Kelsea M. Drall Stephane L. Bourque Catherine J. Field Anita L. Kozyrskyj Benjamin P. Willing The impact of maternal and early life malnutrition on health: a diet-microbe perspective BMC Medicine Undernutrition Malnutrition Diet Microbiome Gastrointestinal Disease |
author_facet |
Andrew J. Forgie Kelsea M. Drall Stephane L. Bourque Catherine J. Field Anita L. Kozyrskyj Benjamin P. Willing |
author_sort |
Andrew J. Forgie |
title |
The impact of maternal and early life malnutrition on health: a diet-microbe perspective |
title_short |
The impact of maternal and early life malnutrition on health: a diet-microbe perspective |
title_full |
The impact of maternal and early life malnutrition on health: a diet-microbe perspective |
title_fullStr |
The impact of maternal and early life malnutrition on health: a diet-microbe perspective |
title_full_unstemmed |
The impact of maternal and early life malnutrition on health: a diet-microbe perspective |
title_sort |
impact of maternal and early life malnutrition on health: a diet-microbe perspective |
publisher |
BMC |
series |
BMC Medicine |
issn |
1741-7015 |
publishDate |
2020-05-01 |
description |
Abstract Background Early-life malnutrition may have long-lasting effects on microbe-host interactions that affect health and disease susceptibility later in life. Diet quality and quantity in conjunction with toxin and pathogen exposure are key contributors to microbe-host physiology and malnutrition. Consequently, it is important to consider both diet- and microbe-induced pathologies as well as their interactions underlying malnutrition. Main Body Gastrointestinal immunity and digestive function are vital to maintain a symbiotic relationship between the host and microbiota. Childhood malnutrition can be impacted by numerous factors including gestational malnutrition, early life antibiotic use, psychological stress, food allergy, hygiene, and exposure to other chemicals and pollutants. These factors can contribute to reoccurring environmental enteropathy, a condition characterized by the expansion of commensal pathobionts and environmental pathogens. Reoccurring intestinal dysfunction, particularly during the critical window of development, may be a consequence of diet-microbe interactions and may lead to life-long immune and metabolic programming and increased disease risk. We provide an overview of the some key factors implicated in the progression of malnutrition (protein, fat, carbohydrate, iron, vitamin D, and vitamin B12) and discuss the microbiota during early life that may contribute health risk later in life. Conclusion Identifying key microbe-host interactions, particularly those associated with diet and malnutrition requires well-controlled dietary studies. Furthering our understanding of diet-microbe-host interactions will help to provide better strategies during gestation and early life to promote health later in life. |
topic |
Undernutrition Malnutrition Diet Microbiome Gastrointestinal Disease |
url |
http://link.springer.com/article/10.1186/s12916-020-01584-z |
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