Circulating MiR-133a as a biomarker predicts cardiac hypertrophy in chronic hemodialysis patients.
BACKGROUND: MicroRNAs (miRNAs) are small ribonucleotides regulating gene expression. MicroRNAs are present in the blood in a remarkably stable form and have emerged as potential diagnostic markers in patients with cardiovascular disease. Our study aimed to assess circulating miR-133a levels in MHD p...
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doaj-349c528a18aa4b2aad0d0e7f2f829ae72020-11-25T01:34:54ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-01910e10307910.1371/journal.pone.0103079Circulating MiR-133a as a biomarker predicts cardiac hypertrophy in chronic hemodialysis patients.Ping WenDan SongHong YeXiaochun WuLei JiangBing TangYang ZhouLi FangHongdi CaoWeichun HeYafang YangChunsun DaiJunwei YangBACKGROUND: MicroRNAs (miRNAs) are small ribonucleotides regulating gene expression. MicroRNAs are present in the blood in a remarkably stable form and have emerged as potential diagnostic markers in patients with cardiovascular disease. Our study aimed to assess circulating miR-133a levels in MHD patients and the relation of miR-133a to cardiac hypertrophy. METHODS: We profiled miRNAs using RNA isolated from the plasma of participants. The results were validated in 64 MHD patients and 18 healthy controls. RESULTS: Levels of plasma miR-133a decreased in MHD patients with LVH compared with those in healthy controls. Plasma miR-133a concentrations were negatively correlated with LVMI and IVS. After single hemodialytic treatment, plasma miR-133a levels remained unchanged. Cardiac Troponin I and T were not associated with LVMI and IVS. CONCLUSIONS: Our observations supplied the possibility that circulating miR-133a could be a surrogate biomarker of cardiac hypertrophy in MHD patients.http://europepmc.org/articles/PMC4196728?pdf=render |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ping Wen Dan Song Hong Ye Xiaochun Wu Lei Jiang Bing Tang Yang Zhou Li Fang Hongdi Cao Weichun He Yafang Yang Chunsun Dai Junwei Yang |
spellingShingle |
Ping Wen Dan Song Hong Ye Xiaochun Wu Lei Jiang Bing Tang Yang Zhou Li Fang Hongdi Cao Weichun He Yafang Yang Chunsun Dai Junwei Yang Circulating MiR-133a as a biomarker predicts cardiac hypertrophy in chronic hemodialysis patients. PLoS ONE |
author_facet |
Ping Wen Dan Song Hong Ye Xiaochun Wu Lei Jiang Bing Tang Yang Zhou Li Fang Hongdi Cao Weichun He Yafang Yang Chunsun Dai Junwei Yang |
author_sort |
Ping Wen |
title |
Circulating MiR-133a as a biomarker predicts cardiac hypertrophy in chronic hemodialysis patients. |
title_short |
Circulating MiR-133a as a biomarker predicts cardiac hypertrophy in chronic hemodialysis patients. |
title_full |
Circulating MiR-133a as a biomarker predicts cardiac hypertrophy in chronic hemodialysis patients. |
title_fullStr |
Circulating MiR-133a as a biomarker predicts cardiac hypertrophy in chronic hemodialysis patients. |
title_full_unstemmed |
Circulating MiR-133a as a biomarker predicts cardiac hypertrophy in chronic hemodialysis patients. |
title_sort |
circulating mir-133a as a biomarker predicts cardiac hypertrophy in chronic hemodialysis patients. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2014-01-01 |
description |
BACKGROUND: MicroRNAs (miRNAs) are small ribonucleotides regulating gene expression. MicroRNAs are present in the blood in a remarkably stable form and have emerged as potential diagnostic markers in patients with cardiovascular disease. Our study aimed to assess circulating miR-133a levels in MHD patients and the relation of miR-133a to cardiac hypertrophy. METHODS: We profiled miRNAs using RNA isolated from the plasma of participants. The results were validated in 64 MHD patients and 18 healthy controls. RESULTS: Levels of plasma miR-133a decreased in MHD patients with LVH compared with those in healthy controls. Plasma miR-133a concentrations were negatively correlated with LVMI and IVS. After single hemodialytic treatment, plasma miR-133a levels remained unchanged. Cardiac Troponin I and T were not associated with LVMI and IVS. CONCLUSIONS: Our observations supplied the possibility that circulating miR-133a could be a surrogate biomarker of cardiac hypertrophy in MHD patients. |
url |
http://europepmc.org/articles/PMC4196728?pdf=render |
work_keys_str_mv |
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