Grading of Frequency Spectral Centroid Across Resting-State Networks
Ongoing, slowly fluctuating brain activity is organized in resting-state networks (RSNs) of spatially coherent fluctuations. Beyond spatial coherence, RSN activity is governed in a frequency-specific manner. The more detailed architecture of frequency spectra across RSNs is, however, poorly understo...
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doaj-34ab2fd8b2ca4edf809fe1ae7484d6d02020-11-25T02:04:20ZengFrontiers Media S.A.Frontiers in Human Neuroscience1662-51612018-10-011210.3389/fnhum.2018.00436414252Grading of Frequency Spectral Centroid Across Resting-State NetworksAnja Ries0Anja Ries1Catie Chang2Sarah Glim3Sarah Glim4Sarah Glim5Chun Meng6Chun Meng7Chun Meng8Christian Sorg9Christian Sorg10Christian Sorg11Afra Wohlschläger12Afra Wohlschläger13Department of Neuroradiology, Technical University of Munich, Munich, GermanyTUM-NIC, Neuroimaging Center, Technical University of Munich, Munich, GermanyAdvanced MRI Section, Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke – National Institutes of Health, Bethesda, MD, United StatesDepartment of Neuroradiology, Technical University of Munich, Munich, GermanyTUM-NIC, Neuroimaging Center, Technical University of Munich, Munich, GermanyGraduate School of Systemic Neurosciences, Ludwig-Maximilians-Universität München, Munich, GermanyDepartment of Neuroradiology, Technical University of Munich, Munich, GermanyTUM-NIC, Neuroimaging Center, Technical University of Munich, Munich, GermanyDepartment of Psychiatry, University of Cambridge, Cambridge, United KingdomDepartment of Neuroradiology, Technical University of Munich, Munich, GermanyTUM-NIC, Neuroimaging Center, Technical University of Munich, Munich, GermanyDepartment of Psychiatry, Technical University of Munich, Munich, GermanyDepartment of Neuroradiology, Technical University of Munich, Munich, GermanyTUM-NIC, Neuroimaging Center, Technical University of Munich, Munich, GermanyOngoing, slowly fluctuating brain activity is organized in resting-state networks (RSNs) of spatially coherent fluctuations. Beyond spatial coherence, RSN activity is governed in a frequency-specific manner. The more detailed architecture of frequency spectra across RSNs is, however, poorly understood. Here we propose a novel measure–the Spectral Centroid (SC)–which represents the center of gravity of the full power spectrum of RSN signal fluctuations. We examine whether spectral underpinnings of network fluctuations are distinct across RSNs. We hypothesize that spectral content differs across networks in a consistent way, thus, the aggregate representation–SC–systematically differs across RSNs. We therefore test for a significant grading (i.e., ordering) of SC across RSNs in healthy subjects. Moreover, we hypothesize that such grading is biologically significant by demonstrating its RSN-specific change through brain disease, namely major depressive disorder. Our results yield a highly organized grading of SC across RSNs in 820 healthy subjects. This ordering was largely replicated in an independent dataset of 25 healthy subjects, pointing toward the validity and consistency of found SC grading across RSNs. Furthermore, we demonstrated the biological relevance of SC grading, as the SC of the salience network–a RSN well known to be implicated in depression–was specifically increased in patients compared to healthy controls. In summary, results provide evidence for a distinct grading of spectra across RSNs, which is sensitive to major depression.https://www.frontiersin.org/article/10.3389/fnhum.2018.00436/fullresting-statefMRIresting-state networksspectral centroidfrequency-based gradingmajor depressive disorder |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Anja Ries Anja Ries Catie Chang Sarah Glim Sarah Glim Sarah Glim Chun Meng Chun Meng Chun Meng Christian Sorg Christian Sorg Christian Sorg Afra Wohlschläger Afra Wohlschläger |
spellingShingle |
Anja Ries Anja Ries Catie Chang Sarah Glim Sarah Glim Sarah Glim Chun Meng Chun Meng Chun Meng Christian Sorg Christian Sorg Christian Sorg Afra Wohlschläger Afra Wohlschläger Grading of Frequency Spectral Centroid Across Resting-State Networks Frontiers in Human Neuroscience resting-state fMRI resting-state networks spectral centroid frequency-based grading major depressive disorder |
author_facet |
Anja Ries Anja Ries Catie Chang Sarah Glim Sarah Glim Sarah Glim Chun Meng Chun Meng Chun Meng Christian Sorg Christian Sorg Christian Sorg Afra Wohlschläger Afra Wohlschläger |
author_sort |
Anja Ries |
title |
Grading of Frequency Spectral Centroid Across Resting-State Networks |
title_short |
Grading of Frequency Spectral Centroid Across Resting-State Networks |
title_full |
Grading of Frequency Spectral Centroid Across Resting-State Networks |
title_fullStr |
Grading of Frequency Spectral Centroid Across Resting-State Networks |
title_full_unstemmed |
Grading of Frequency Spectral Centroid Across Resting-State Networks |
title_sort |
grading of frequency spectral centroid across resting-state networks |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Human Neuroscience |
issn |
1662-5161 |
publishDate |
2018-10-01 |
description |
Ongoing, slowly fluctuating brain activity is organized in resting-state networks (RSNs) of spatially coherent fluctuations. Beyond spatial coherence, RSN activity is governed in a frequency-specific manner. The more detailed architecture of frequency spectra across RSNs is, however, poorly understood. Here we propose a novel measure–the Spectral Centroid (SC)–which represents the center of gravity of the full power spectrum of RSN signal fluctuations. We examine whether spectral underpinnings of network fluctuations are distinct across RSNs. We hypothesize that spectral content differs across networks in a consistent way, thus, the aggregate representation–SC–systematically differs across RSNs. We therefore test for a significant grading (i.e., ordering) of SC across RSNs in healthy subjects. Moreover, we hypothesize that such grading is biologically significant by demonstrating its RSN-specific change through brain disease, namely major depressive disorder. Our results yield a highly organized grading of SC across RSNs in 820 healthy subjects. This ordering was largely replicated in an independent dataset of 25 healthy subjects, pointing toward the validity and consistency of found SC grading across RSNs. Furthermore, we demonstrated the biological relevance of SC grading, as the SC of the salience network–a RSN well known to be implicated in depression–was specifically increased in patients compared to healthy controls. In summary, results provide evidence for a distinct grading of spectra across RSNs, which is sensitive to major depression. |
topic |
resting-state fMRI resting-state networks spectral centroid frequency-based grading major depressive disorder |
url |
https://www.frontiersin.org/article/10.3389/fnhum.2018.00436/full |
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