CSF-Progranulin and Neurofilament Light Chain Levels in Patients With Radiologically Isolated Syndrome—Sign of Inflammation
Background: Cerebrospinal fluid (CSF) markers of disease in patients with radiologically isolated syndrome (RIS) are the subject of intense investigation, because they have the potential to enhance our understanding of the natural disease course and provide insights into similarities and differences...
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doaj-34af01215adb4e3d80fd973765c5e6db2020-11-24T21:49:59ZengFrontiers Media S.A.Frontiers in Neurology1664-22952018-12-01910.3389/fneur.2018.01075431610CSF-Progranulin and Neurofilament Light Chain Levels in Patients With Radiologically Isolated Syndrome—Sign of InflammationMarc Pawlitzki0Marc Pawlitzki1Catherine M. Sweeney-Reed2Daniel Bittner3Anke Lux4Stefan Vielhaber5Stefanie Schreiber6Friedemann Paul7Friedemann Paul8Friedemann Paul9Jens Neumann10Department of Neurology, Otto-von-Guericke University, Magdeburg, GermanyDepartment of Neurology with Institute of Translational Neurology, University Hospital of Muenster, Münster, GermanyDepartment of Neurology, Otto-von-Guericke University, Magdeburg, GermanyDepartment of Neurology, Otto-von-Guericke University, Magdeburg, GermanyDepartment for Biometrics and Medical Informatics, Otto-von-Guericke-University, Magdeburg, GermanyDepartment of Neurology, Otto-von-Guericke University, Magdeburg, GermanyDepartment of Neurology, Otto-von-Guericke University, Magdeburg, GermanyCharité – Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, NeuroCure Clinical Research Center, Berlin, GermanyCharité – Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Neurology, Berlin, GermanyExperimental and Clinical Research Center, Max Delbrueck Center for Molecular Medicine and Charité – Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, GermanyDepartment of Neurology, Otto-von-Guericke University, Magdeburg, GermanyBackground: Cerebrospinal fluid (CSF) markers of disease in patients with radiologically isolated syndrome (RIS) are the subject of intense investigation, because they have the potential to enhance our understanding of the natural disease course and provide insights into similarities and differences between RIS and other multiple sclerosis (MS) disease identities.Methods: Here we compared neurofilament light chain (NFL) and progranulin (PGRN) levels in the CSF in RIS patients with levels in patients with different subtypes of MS and healthy controls (HC) using Kruskal–Wallis one-way analysis of variance.Results: Median CSF NFL concentrations in RIS patients did not differ to those in HC and clinically isolated syndrome (CIS) patients, but were significantly lower than in relapsing remitting (RRMS) and primary progressive (PPMS) MS patients. In contrast, RIS patients exhibited higher median CSF PGRN levels than HC and showed no significant differences compared with CIS, RRMS, and PPMS cases.Conclusion: We postulate that elevated PGRN values in the CSF of RIS patients might indicate inflammatory and repair activity prior to axonal disintegration.https://www.frontiersin.org/article/10.3389/fneur.2018.01075/fullmultiple sclerosisradiologically isolated syndromecerebrospinal fluidneurofilament light chainprogranulin |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Marc Pawlitzki Marc Pawlitzki Catherine M. Sweeney-Reed Daniel Bittner Anke Lux Stefan Vielhaber Stefanie Schreiber Friedemann Paul Friedemann Paul Friedemann Paul Jens Neumann |
spellingShingle |
Marc Pawlitzki Marc Pawlitzki Catherine M. Sweeney-Reed Daniel Bittner Anke Lux Stefan Vielhaber Stefanie Schreiber Friedemann Paul Friedemann Paul Friedemann Paul Jens Neumann CSF-Progranulin and Neurofilament Light Chain Levels in Patients With Radiologically Isolated Syndrome—Sign of Inflammation Frontiers in Neurology multiple sclerosis radiologically isolated syndrome cerebrospinal fluid neurofilament light chain progranulin |
author_facet |
Marc Pawlitzki Marc Pawlitzki Catherine M. Sweeney-Reed Daniel Bittner Anke Lux Stefan Vielhaber Stefanie Schreiber Friedemann Paul Friedemann Paul Friedemann Paul Jens Neumann |
author_sort |
Marc Pawlitzki |
title |
CSF-Progranulin and Neurofilament Light Chain Levels in Patients With Radiologically Isolated Syndrome—Sign of Inflammation |
title_short |
CSF-Progranulin and Neurofilament Light Chain Levels in Patients With Radiologically Isolated Syndrome—Sign of Inflammation |
title_full |
CSF-Progranulin and Neurofilament Light Chain Levels in Patients With Radiologically Isolated Syndrome—Sign of Inflammation |
title_fullStr |
CSF-Progranulin and Neurofilament Light Chain Levels in Patients With Radiologically Isolated Syndrome—Sign of Inflammation |
title_full_unstemmed |
CSF-Progranulin and Neurofilament Light Chain Levels in Patients With Radiologically Isolated Syndrome—Sign of Inflammation |
title_sort |
csf-progranulin and neurofilament light chain levels in patients with radiologically isolated syndrome—sign of inflammation |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Neurology |
issn |
1664-2295 |
publishDate |
2018-12-01 |
description |
Background: Cerebrospinal fluid (CSF) markers of disease in patients with radiologically isolated syndrome (RIS) are the subject of intense investigation, because they have the potential to enhance our understanding of the natural disease course and provide insights into similarities and differences between RIS and other multiple sclerosis (MS) disease identities.Methods: Here we compared neurofilament light chain (NFL) and progranulin (PGRN) levels in the CSF in RIS patients with levels in patients with different subtypes of MS and healthy controls (HC) using Kruskal–Wallis one-way analysis of variance.Results: Median CSF NFL concentrations in RIS patients did not differ to those in HC and clinically isolated syndrome (CIS) patients, but were significantly lower than in relapsing remitting (RRMS) and primary progressive (PPMS) MS patients. In contrast, RIS patients exhibited higher median CSF PGRN levels than HC and showed no significant differences compared with CIS, RRMS, and PPMS cases.Conclusion: We postulate that elevated PGRN values in the CSF of RIS patients might indicate inflammatory and repair activity prior to axonal disintegration. |
topic |
multiple sclerosis radiologically isolated syndrome cerebrospinal fluid neurofilament light chain progranulin |
url |
https://www.frontiersin.org/article/10.3389/fneur.2018.01075/full |
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