Clinical Efficacy of Solifenacin in the Management of Diabetes Mellitus-Associated Versus Idiopathic Overactive Bladder Symptoms: A Multicenter Prospective Study
Purpose To compare the clinical efficacy of anticholinergics for managing diabetes mellitus-associated overactive bladder (DM OAB) versus idiopathic overactive bladder (OAB) in Korean women. Methods We conducted a multicenter, prospective, parallel-group, open-label, 12-week study. Women (20–65 year...
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doaj-34b136864f28422181a9f55e7de0d0942020-11-24T21:52:47ZengKorean Continence SocietyInternational Neurourology Journal2093-47772093-69312018-03-01221515710.5213/inj.1834982.491716Clinical Efficacy of Solifenacin in the Management of Diabetes Mellitus-Associated Versus Idiopathic Overactive Bladder Symptoms: A Multicenter Prospective StudyHoon Choi0Jae Hyun Bae1Cheol Young Oh2Seong Jin Jeong3Woo Jin Ko4Jong Bo Choi5Ju Tae Seo6Dong Hwan Lee7Joon Chul Kim8Kwang Woo Lee9Young Ho Kim10 Department of Urology, Korea University Hospital, Korea University College of Medicine, Ansan, Korea Department of Urology, Korea University Hospital, Korea University College of Medicine, Ansan, Korea Department of Urology, Hallym University College of Medicine, Chuncheon, Korea Department of Urology, Seoul National University Bundang Hospital, Seongnam, Korea Department of Urology, National Health Insurance Service Ilsan Hospital, Yonsei University College of Medicine, Goyang, Korea Department of Urology, Ajou University College of Medicine, Suwon, Korea Department of Urology, Cheil General Hospital and Women’s Healthcare Center, Dankook University College of Medicine, Seoul, Korea Department of Urology, Incheon St. Mary’s Hospital, The Catholic University College of Medicine, Incheon, Korea Department of Urology, Bucheon St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Bucheon, Korea Department of Urology, Soonchunhyang University Hospital, Soonchunhyang University College of Medicine, Bucheon, Korea Department of Urology, Soonchunhyang University Hospital, Soonchunhyang University College of Medicine, Bucheon, KoreaPurpose To compare the clinical efficacy of anticholinergics for managing diabetes mellitus-associated overactive bladder (DM OAB) versus idiopathic overactive bladder (OAB) in Korean women. Methods We conducted a multicenter, prospective, parallel-group, open-label, 12-week study. Women (20–65 years old) with OAB symptoms for over 3 months were assigned to the DM OAB and idiopathic OAB groups. Changes in the Overactive Bladder Symptom Score (OABSS), urgency, urinary urgency incontinence, nocturia, daytime frequency according to a voiding diary, uroflowmetry, and postvoid residual urine volume (PVR) at the first visit (V1), week 4 (V2), and week 12 (V3) were compared. Results No significant difference was found between the baseline patient characteristics of the DM OAB and idiopathic OAB groups. Treatment with solifenacin was associated with improvements in urgency, urinary urgency incontinence, nocturia, frequency according to a voiding diary, and the total OABSS between V1 and V2 and between V1 and V3. Moreover, a significant improvement in urgency and urge incontinence was found between V2 and V3 in the DM OAB group. However, no significant changes were found in any other parameters. There were no significant differences between the DM OAB group and the idiopathic OAB group except for urgency and urge incontinence at V2 (3.71 vs. 2.28 and 0.47 vs. 0.32, respectively). Conclusions The patients who received solifenacin demonstrated improved urgency, urinary urgency incontinence, nocturia, frequency according to a voiding diary, and total OABSS. Management with solifenacin was equally effective for both DM-related OAB and idiopathic OAB.http://www.einj.org/upload/pdf/inj-1834982-491.pdfAnticholinergicsOveractive urinary bladderDiabetes mellitus |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Hoon Choi Jae Hyun Bae Cheol Young Oh Seong Jin Jeong Woo Jin Ko Jong Bo Choi Ju Tae Seo Dong Hwan Lee Joon Chul Kim Kwang Woo Lee Young Ho Kim |
spellingShingle |
Hoon Choi Jae Hyun Bae Cheol Young Oh Seong Jin Jeong Woo Jin Ko Jong Bo Choi Ju Tae Seo Dong Hwan Lee Joon Chul Kim Kwang Woo Lee Young Ho Kim Clinical Efficacy of Solifenacin in the Management of Diabetes Mellitus-Associated Versus Idiopathic Overactive Bladder Symptoms: A Multicenter Prospective Study International Neurourology Journal Anticholinergics Overactive urinary bladder Diabetes mellitus |
author_facet |
Hoon Choi Jae Hyun Bae Cheol Young Oh Seong Jin Jeong Woo Jin Ko Jong Bo Choi Ju Tae Seo Dong Hwan Lee Joon Chul Kim Kwang Woo Lee Young Ho Kim |
author_sort |
Hoon Choi |
title |
Clinical Efficacy of Solifenacin in the Management of Diabetes Mellitus-Associated Versus Idiopathic Overactive Bladder Symptoms: A Multicenter Prospective Study |
title_short |
Clinical Efficacy of Solifenacin in the Management of Diabetes Mellitus-Associated Versus Idiopathic Overactive Bladder Symptoms: A Multicenter Prospective Study |
title_full |
Clinical Efficacy of Solifenacin in the Management of Diabetes Mellitus-Associated Versus Idiopathic Overactive Bladder Symptoms: A Multicenter Prospective Study |
title_fullStr |
Clinical Efficacy of Solifenacin in the Management of Diabetes Mellitus-Associated Versus Idiopathic Overactive Bladder Symptoms: A Multicenter Prospective Study |
title_full_unstemmed |
Clinical Efficacy of Solifenacin in the Management of Diabetes Mellitus-Associated Versus Idiopathic Overactive Bladder Symptoms: A Multicenter Prospective Study |
title_sort |
clinical efficacy of solifenacin in the management of diabetes mellitus-associated versus idiopathic overactive bladder symptoms: a multicenter prospective study |
publisher |
Korean Continence Society |
series |
International Neurourology Journal |
issn |
2093-4777 2093-6931 |
publishDate |
2018-03-01 |
description |
Purpose To compare the clinical efficacy of anticholinergics for managing diabetes mellitus-associated overactive bladder (DM OAB) versus idiopathic overactive bladder (OAB) in Korean women. Methods We conducted a multicenter, prospective, parallel-group, open-label, 12-week study. Women (20–65 years old) with OAB symptoms for over 3 months were assigned to the DM OAB and idiopathic OAB groups. Changes in the Overactive Bladder Symptom Score (OABSS), urgency, urinary urgency incontinence, nocturia, daytime frequency according to a voiding diary, uroflowmetry, and postvoid residual urine volume (PVR) at the first visit (V1), week 4 (V2), and week 12 (V3) were compared. Results No significant difference was found between the baseline patient characteristics of the DM OAB and idiopathic OAB groups. Treatment with solifenacin was associated with improvements in urgency, urinary urgency incontinence, nocturia, frequency according to a voiding diary, and the total OABSS between V1 and V2 and between V1 and V3. Moreover, a significant improvement in urgency and urge incontinence was found between V2 and V3 in the DM OAB group. However, no significant changes were found in any other parameters. There were no significant differences between the DM OAB group and the idiopathic OAB group except for urgency and urge incontinence at V2 (3.71 vs. 2.28 and 0.47 vs. 0.32, respectively). Conclusions The patients who received solifenacin demonstrated improved urgency, urinary urgency incontinence, nocturia, frequency according to a voiding diary, and total OABSS. Management with solifenacin was equally effective for both DM-related OAB and idiopathic OAB. |
topic |
Anticholinergics Overactive urinary bladder Diabetes mellitus |
url |
http://www.einj.org/upload/pdf/inj-1834982-491.pdf |
work_keys_str_mv |
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