Effect of low doses of bezafibrate and fenofibrate on liver 2-oxo-glutarate dehydrogenase complex in low-protein diet fed rats
Multienzyme 2-oxoglutarate complex (2-OGDH) together with branched chain ?-ketoacid dehydrogenase (BCKDH) and pyruvate dehydrogenase belong to the family of mitochondrial 2-oxoacid dehydrogenases. Hypolipidemic drugs, bezafibrate and fenofibrate, up-regulate liver BCKDH. The present study has been...
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doaj-34b4993ac8c3451eac9b0bdcf3a027382020-11-25T00:01:44ZengBangladesh Pharmacological SocietyBangladesh Journal of Pharmacology1991-00882015-07-01103Effect of low doses of bezafibrate and fenofibrate on liver 2-oxo-glutarate dehydrogenase complex in low-protein diet fed ratsMalgorzata Elzbieta Knapik-Czajka0Department of Analytical Biochemistry, Faculty of Pharmacy, Jagiellonian University Medical College, Krakow Multienzyme 2-oxoglutarate complex (2-OGDH) together with branched chain ?-ketoacid dehydrogenase (BCKDH) and pyruvate dehydrogenase belong to the family of mitochondrial 2-oxoacid dehydrogenases. Hypolipidemic drugs, bezafibrate and fenofibrate, up-regulate liver BCKDH. The present study has been undertaken to determine the effect of low doses of bezafibrate and fenofibrate on liver 2-OGDH. Fibrates were administrated to rats fed low-protein diet at 5, 10 or 20 mg/kg. In rats treated with increasing doses of bezafibrate 2-OGDH activity increased by 7, 35 and 42%, while in rats administered with fenofibrate by 8, 18, and 56% (p<0.05 for bezafibrate 10 and 20, and fenofibrate 20 mg/kg). Changes in 2-OGDH activity did not correspond with changes in mRNA levels of the complex enzymes. Moreover, mRNA levels of PPAR? remained unaltered. It is conceivable that stimulation of 2-OGDH activity by low doses of fibrates is the result of post-transcriptional events and may have a significant effect on liver metabolism. https://www.banglajol.info/index.php/BJP/article/view/23101BezafibrateFenofibrate2-Oxoglutarate dehydrogenase |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Malgorzata Elzbieta Knapik-Czajka |
spellingShingle |
Malgorzata Elzbieta Knapik-Czajka Effect of low doses of bezafibrate and fenofibrate on liver 2-oxo-glutarate dehydrogenase complex in low-protein diet fed rats Bangladesh Journal of Pharmacology Bezafibrate Fenofibrate 2-Oxoglutarate dehydrogenase |
author_facet |
Malgorzata Elzbieta Knapik-Czajka |
author_sort |
Malgorzata Elzbieta Knapik-Czajka |
title |
Effect of low doses of bezafibrate and fenofibrate on liver 2-oxo-glutarate dehydrogenase complex in low-protein diet fed rats |
title_short |
Effect of low doses of bezafibrate and fenofibrate on liver 2-oxo-glutarate dehydrogenase complex in low-protein diet fed rats |
title_full |
Effect of low doses of bezafibrate and fenofibrate on liver 2-oxo-glutarate dehydrogenase complex in low-protein diet fed rats |
title_fullStr |
Effect of low doses of bezafibrate and fenofibrate on liver 2-oxo-glutarate dehydrogenase complex in low-protein diet fed rats |
title_full_unstemmed |
Effect of low doses of bezafibrate and fenofibrate on liver 2-oxo-glutarate dehydrogenase complex in low-protein diet fed rats |
title_sort |
effect of low doses of bezafibrate and fenofibrate on liver 2-oxo-glutarate dehydrogenase complex in low-protein diet fed rats |
publisher |
Bangladesh Pharmacological Society |
series |
Bangladesh Journal of Pharmacology |
issn |
1991-0088 |
publishDate |
2015-07-01 |
description |
Multienzyme 2-oxoglutarate complex (2-OGDH) together with branched chain ?-ketoacid dehydrogenase (BCKDH) and pyruvate dehydrogenase belong to the family of mitochondrial 2-oxoacid dehydrogenases. Hypolipidemic drugs, bezafibrate and fenofibrate, up-regulate liver BCKDH. The present study has been undertaken to determine the effect of low doses of bezafibrate and fenofibrate on liver 2-OGDH. Fibrates were administrated to rats fed low-protein diet at 5, 10 or 20 mg/kg. In rats treated with increasing doses of bezafibrate 2-OGDH activity increased by 7, 35 and 42%, while in rats administered with fenofibrate by 8, 18, and 56% (p<0.05 for bezafibrate 10 and 20, and fenofibrate 20 mg/kg). Changes in 2-OGDH activity did not correspond with changes in mRNA levels of the complex enzymes. Moreover, mRNA levels of PPAR? remained unaltered. It is conceivable that stimulation of 2-OGDH activity by low doses of fibrates is the result of post-transcriptional events and may have a significant effect on liver metabolism.
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topic |
Bezafibrate Fenofibrate 2-Oxoglutarate dehydrogenase |
url |
https://www.banglajol.info/index.php/BJP/article/view/23101 |
work_keys_str_mv |
AT malgorzataelzbietaknapikczajka effectoflowdosesofbezafibrateandfenofibrateonliver2oxoglutaratedehydrogenasecomplexinlowproteindietfedrats |
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