Cisplatin-induced vestibular hair cell lesion-less damage at high doses

Cisplatin, a widely used anticancer drug, damages hair cells in cochlear organotypic cultures at low doses, but paradoxically causes little damage at high doses resulting in a U-shaped dose-response function. To determine if the cisplatin dose-response function for vestibular hair cells follows a si...

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Bibliographic Details
Main Authors: Dalian Ding, Haiyan Jiang, Jianhui Zhang, Xianrong Xu, Weidong Qi, Haibo Shi, Shankai Yin, Richard Salvi
Format: Article
Language:English
Published: Elsevier 2018-12-01
Series:Journal of Otology
Online Access:http://www.sciencedirect.com/science/article/pii/S1672293018300527

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