C-Reactive Protein Is an Independent Predictor of 30-Day Bacterial Infection Post-Liver Transplantation
The relationship between aseptic systemic inflammation and postoperative bacterial infection is unclear. We investigated the correlation of systemic inflammation biomarkers with 30-day clinically significant bacterial infections (CSI) after liver transplantation (LT). This retrospective study enroll...
Main Authors: | , , , , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2021-08-01
|
Series: | Biomolecules |
Subjects: | |
Online Access: | https://www.mdpi.com/2218-273X/11/8/1195 |
id |
doaj-34be5f6ad0ba48dab2f39504b55766f0 |
---|---|
record_format |
Article |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jiong Yu Xiaowei Shi Jing Ma Ronggao Chen Siyi Dong Sen Lu Jian Wu Cuilin Yan Jian Wu Shusen Zheng Lanjuan Li Xiao Xu Hongcui Cao |
spellingShingle |
Jiong Yu Xiaowei Shi Jing Ma Ronggao Chen Siyi Dong Sen Lu Jian Wu Cuilin Yan Jian Wu Shusen Zheng Lanjuan Li Xiao Xu Hongcui Cao C-Reactive Protein Is an Independent Predictor of 30-Day Bacterial Infection Post-Liver Transplantation Biomolecules liver transplantation systemic inflammation C-reactive protein MELD score bacterial infection |
author_facet |
Jiong Yu Xiaowei Shi Jing Ma Ronggao Chen Siyi Dong Sen Lu Jian Wu Cuilin Yan Jian Wu Shusen Zheng Lanjuan Li Xiao Xu Hongcui Cao |
author_sort |
Jiong Yu |
title |
C-Reactive Protein Is an Independent Predictor of 30-Day Bacterial Infection Post-Liver Transplantation |
title_short |
C-Reactive Protein Is an Independent Predictor of 30-Day Bacterial Infection Post-Liver Transplantation |
title_full |
C-Reactive Protein Is an Independent Predictor of 30-Day Bacterial Infection Post-Liver Transplantation |
title_fullStr |
C-Reactive Protein Is an Independent Predictor of 30-Day Bacterial Infection Post-Liver Transplantation |
title_full_unstemmed |
C-Reactive Protein Is an Independent Predictor of 30-Day Bacterial Infection Post-Liver Transplantation |
title_sort |
c-reactive protein is an independent predictor of 30-day bacterial infection post-liver transplantation |
publisher |
MDPI AG |
series |
Biomolecules |
issn |
2218-273X |
publishDate |
2021-08-01 |
description |
The relationship between aseptic systemic inflammation and postoperative bacterial infection is unclear. We investigated the correlation of systemic inflammation biomarkers with 30-day clinically significant bacterial infections (CSI) after liver transplantation (LT). This retrospective study enrolled 940 patients who received LT and were followed for 30 days. The primary end point was 30-day CSI events. The cohort was divided into exploratory (<i>n</i> = 508) and validation (<i>n</i> = 432) sets according to different centers. Area under the receiver operated characteristic (AUROC) and Cox regression models were fitted to study the association between baseline systemic inflammation levels and CSI after LT. A total of 255 bacterial infectious events in 209 recipients occurred. Among systemic inflammation parameters, baseline C-reactive protein (CRP) was independently associated with 30-day CSI in the exploratory group. The combination of CRP and organ failure number showed a good discrimination for 30-day CSI (AUROC = 0.80, 95% CI, 0.76–0.84) and the results were confirmed in an external verification group. Additionally, CRP levels were correlated with bacterial product lipopolysaccharide. In conclusion, our study suggests that pre-transplantation CRP is independent of other prognostic factors for 30-day CSI post-LT, and can be integrated into tools for assessing the risk of bacterial infection post-LT or as a component of prognostic models. |
topic |
liver transplantation systemic inflammation C-reactive protein MELD score bacterial infection |
url |
https://www.mdpi.com/2218-273X/11/8/1195 |
work_keys_str_mv |
AT jiongyu creactiveproteinisanindependentpredictorof30daybacterialinfectionpostlivertransplantation AT xiaoweishi creactiveproteinisanindependentpredictorof30daybacterialinfectionpostlivertransplantation AT jingma creactiveproteinisanindependentpredictorof30daybacterialinfectionpostlivertransplantation AT ronggaochen creactiveproteinisanindependentpredictorof30daybacterialinfectionpostlivertransplantation AT siyidong creactiveproteinisanindependentpredictorof30daybacterialinfectionpostlivertransplantation AT senlu creactiveproteinisanindependentpredictorof30daybacterialinfectionpostlivertransplantation AT jianwu creactiveproteinisanindependentpredictorof30daybacterialinfectionpostlivertransplantation AT cuilinyan creactiveproteinisanindependentpredictorof30daybacterialinfectionpostlivertransplantation AT jianwu creactiveproteinisanindependentpredictorof30daybacterialinfectionpostlivertransplantation AT shusenzheng creactiveproteinisanindependentpredictorof30daybacterialinfectionpostlivertransplantation AT lanjuanli creactiveproteinisanindependentpredictorof30daybacterialinfectionpostlivertransplantation AT xiaoxu creactiveproteinisanindependentpredictorof30daybacterialinfectionpostlivertransplantation AT hongcuicao creactiveproteinisanindependentpredictorof30daybacterialinfectionpostlivertransplantation |
_version_ |
1721194684802400256 |
spelling |
doaj-34be5f6ad0ba48dab2f39504b55766f02021-08-26T13:33:53ZengMDPI AGBiomolecules2218-273X2021-08-01111195119510.3390/biom11081195C-Reactive Protein Is an Independent Predictor of 30-Day Bacterial Infection Post-Liver TransplantationJiong Yu0Xiaowei Shi1Jing Ma2Ronggao Chen3Siyi Dong4Sen Lu5Jian Wu6Cuilin Yan7Jian Wu8Shusen Zheng9Lanjuan Li10Xiao Xu11Hongcui Cao12State Key Laboratory for the Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, 79 Qingchun Rd., Hangzhou 310003, ChinaState Key Laboratory for the Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, 79 Qingchun Rd., Hangzhou 310003, ChinaState Key Laboratory for the Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, 79 Qingchun Rd., Hangzhou 310003, ChinaNHC Key Laboratory of Combined Multi-Organ Transplantation, Key Laboratory of the Diagnosis and Treatment of Organ Transplantation, CAMS, Hangzhou 310003, ChinaNHC Key Laboratory of Combined Multi-Organ Transplantation, Key Laboratory of the Diagnosis and Treatment of Organ Transplantation, CAMS, Hangzhou 310003, ChinaDepartment of Colorectal Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, ChinaState Key Laboratory for the Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, 79 Qingchun Rd., Hangzhou 310003, ChinaState Key Laboratory for the Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, 79 Qingchun Rd., Hangzhou 310003, ChinaNHC Key Laboratory of Combined Multi-Organ Transplantation, Key Laboratory of the Diagnosis and Treatment of Organ Transplantation, CAMS, Hangzhou 310003, ChinaState Key Laboratory for the Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, 79 Qingchun Rd., Hangzhou 310003, ChinaState Key Laboratory for the Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, 79 Qingchun Rd., Hangzhou 310003, ChinaState Key Laboratory for the Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, 79 Qingchun Rd., Hangzhou 310003, ChinaState Key Laboratory for the Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, 79 Qingchun Rd., Hangzhou 310003, ChinaThe relationship between aseptic systemic inflammation and postoperative bacterial infection is unclear. We investigated the correlation of systemic inflammation biomarkers with 30-day clinically significant bacterial infections (CSI) after liver transplantation (LT). This retrospective study enrolled 940 patients who received LT and were followed for 30 days. The primary end point was 30-day CSI events. The cohort was divided into exploratory (<i>n</i> = 508) and validation (<i>n</i> = 432) sets according to different centers. Area under the receiver operated characteristic (AUROC) and Cox regression models were fitted to study the association between baseline systemic inflammation levels and CSI after LT. A total of 255 bacterial infectious events in 209 recipients occurred. Among systemic inflammation parameters, baseline C-reactive protein (CRP) was independently associated with 30-day CSI in the exploratory group. The combination of CRP and organ failure number showed a good discrimination for 30-day CSI (AUROC = 0.80, 95% CI, 0.76–0.84) and the results were confirmed in an external verification group. Additionally, CRP levels were correlated with bacterial product lipopolysaccharide. In conclusion, our study suggests that pre-transplantation CRP is independent of other prognostic factors for 30-day CSI post-LT, and can be integrated into tools for assessing the risk of bacterial infection post-LT or as a component of prognostic models.https://www.mdpi.com/2218-273X/11/8/1195liver transplantationsystemic inflammationC-reactive proteinMELD scorebacterial infection |