Comparison of postoperative analgesic efficacy of low-dose bolus intravenous dexmedetomidine and intraperitoneal dexmedetomidine with bupivacaine in patients undergoing laparoscopic cholecystectomy: A randomised, controlled trial
Background and Aims: Recently, low-dose intravenous (IV) dexmedetomidine has been evaluated for obtunding the pneumoperitoneum-induced haemodynamic changes and its analgesic efficacy in laparoscopic cholecystectomy. The aim was to determine the postoperative analgesic efficacy of low-dose bolus of 0...
Main Authors: | , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Wolters Kluwer Medknow Publications
2019-01-01
|
Series: | Indian Journal of Anaesthesia |
Subjects: | |
Online Access: | http://www.ijaweb.org/article.asp?issn=0019-5049;year=2019;volume=63;issue=2;spage=106;epage=113;aulast=Chilkoti |
id |
doaj-34c3e295558b49e982c00ab01b554542 |
---|---|
record_format |
Article |
spelling |
doaj-34c3e295558b49e982c00ab01b5545422020-11-25T01:51:37ZengWolters Kluwer Medknow PublicationsIndian Journal of Anaesthesia0019-50490976-28172019-01-0163210611310.4103/ija.IJA_440_18Comparison of postoperative analgesic efficacy of low-dose bolus intravenous dexmedetomidine and intraperitoneal dexmedetomidine with bupivacaine in patients undergoing laparoscopic cholecystectomy: A randomised, controlled trialGeetanjali Tolia ChilkotiManish KumarMedha MohtaAshok Kumar SaxenaNaveen SharmaJitender SinghBackground and Aims: Recently, low-dose intravenous (IV) dexmedetomidine has been evaluated for obtunding the pneumoperitoneum-induced haemodynamic changes and its analgesic efficacy in laparoscopic cholecystectomy. The aim was to determine the postoperative analgesic efficacy of low-dose bolus of 0.5 μg/kg dexmedetomidine via IV and intraperitoneal (IP) route in laparoscopic cholecystectomy. Methods: Seventy-five patients, aged 18–60 years of ASA physical status I and II, undergoing laparoscopic cholecystectomy under general anaesthesia were included. Patients in Group C received IP bupivacaine. Patients in Group IV received 0.5 μg/kg dexmedetomidine infusion IV after removal of gall bladder along with IP bupivacaine and Group IP received 0.5 μg/kg dexmedetomidine in 40 mL of 0.25% bupivacaine IP. The primary outcome was 'time to first request of analgesia' and the secondary outcomes were 'total consumption of tramadol in 24 hours,' visual analogue scale (VAS) pain score. Results: In total, 75 patients with 25 in each group were included. Time to first request of analgesia was found to be significantly lower in IV (59.68 ± 71.05 min, P= 0.00) and IP group (90.80 ± 80.46 min, P = 0.001) compared tp Group C (59.68 ± 71.05 min). Mean tramadol consumption in 24 hours (152.40 ± 60.958 vs 137.64 ± 52.40 mg) and mean VAS pain score were comparable in both IV and IP groups in the initial 12 h. Conclusion: Low bolus dose of IP dexmedetomidine is as efficacious as IV dexmedetomidine (0.5 μg/kg) along with IP bupivacaine in laparoscopic cholecystectomy.http://www.ijaweb.org/article.asp?issn=0019-5049;year=2019;volume=63;issue=2;spage=106;epage=113;aulast=ChilkotiAnalgesiabupivacainecholecystectomydexmedetomidineintraperitonealintravenous |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Geetanjali Tolia Chilkoti Manish Kumar Medha Mohta Ashok Kumar Saxena Naveen Sharma Jitender Singh |
spellingShingle |
Geetanjali Tolia Chilkoti Manish Kumar Medha Mohta Ashok Kumar Saxena Naveen Sharma Jitender Singh Comparison of postoperative analgesic efficacy of low-dose bolus intravenous dexmedetomidine and intraperitoneal dexmedetomidine with bupivacaine in patients undergoing laparoscopic cholecystectomy: A randomised, controlled trial Indian Journal of Anaesthesia Analgesia bupivacaine cholecystectomy dexmedetomidine intraperitoneal intravenous |
author_facet |
Geetanjali Tolia Chilkoti Manish Kumar Medha Mohta Ashok Kumar Saxena Naveen Sharma Jitender Singh |
author_sort |
Geetanjali Tolia Chilkoti |
title |
Comparison of postoperative analgesic efficacy of low-dose bolus intravenous dexmedetomidine and intraperitoneal dexmedetomidine with bupivacaine in patients undergoing laparoscopic cholecystectomy: A randomised, controlled trial |
title_short |
Comparison of postoperative analgesic efficacy of low-dose bolus intravenous dexmedetomidine and intraperitoneal dexmedetomidine with bupivacaine in patients undergoing laparoscopic cholecystectomy: A randomised, controlled trial |
title_full |
Comparison of postoperative analgesic efficacy of low-dose bolus intravenous dexmedetomidine and intraperitoneal dexmedetomidine with bupivacaine in patients undergoing laparoscopic cholecystectomy: A randomised, controlled trial |
title_fullStr |
Comparison of postoperative analgesic efficacy of low-dose bolus intravenous dexmedetomidine and intraperitoneal dexmedetomidine with bupivacaine in patients undergoing laparoscopic cholecystectomy: A randomised, controlled trial |
title_full_unstemmed |
Comparison of postoperative analgesic efficacy of low-dose bolus intravenous dexmedetomidine and intraperitoneal dexmedetomidine with bupivacaine in patients undergoing laparoscopic cholecystectomy: A randomised, controlled trial |
title_sort |
comparison of postoperative analgesic efficacy of low-dose bolus intravenous dexmedetomidine and intraperitoneal dexmedetomidine with bupivacaine in patients undergoing laparoscopic cholecystectomy: a randomised, controlled trial |
publisher |
Wolters Kluwer Medknow Publications |
series |
Indian Journal of Anaesthesia |
issn |
0019-5049 0976-2817 |
publishDate |
2019-01-01 |
description |
Background and Aims: Recently, low-dose intravenous (IV) dexmedetomidine has been evaluated for obtunding the pneumoperitoneum-induced haemodynamic changes and its analgesic efficacy in laparoscopic cholecystectomy. The aim was to determine the postoperative analgesic efficacy of low-dose bolus of 0.5 μg/kg dexmedetomidine via IV and intraperitoneal (IP) route in laparoscopic cholecystectomy. Methods: Seventy-five patients, aged 18–60 years of ASA physical status I and II, undergoing laparoscopic cholecystectomy under general anaesthesia were included. Patients in Group C received IP bupivacaine. Patients in Group IV received 0.5 μg/kg dexmedetomidine infusion IV after removal of gall bladder along with IP bupivacaine and Group IP received 0.5 μg/kg dexmedetomidine in 40 mL of 0.25% bupivacaine IP. The primary outcome was 'time to first request of analgesia' and the secondary outcomes were 'total consumption of tramadol in 24 hours,' visual analogue scale (VAS) pain score. Results: In total, 75 patients with 25 in each group were included. Time to first request of analgesia was found to be significantly lower in IV (59.68 ± 71.05 min, P= 0.00) and IP group (90.80 ± 80.46 min, P = 0.001) compared tp Group C (59.68 ± 71.05 min). Mean tramadol consumption in 24 hours (152.40 ± 60.958 vs 137.64 ± 52.40 mg) and mean VAS pain score were comparable in both IV and IP groups in the initial 12 h. Conclusion: Low bolus dose of IP dexmedetomidine is as efficacious as IV dexmedetomidine (0.5 μg/kg) along with IP bupivacaine in laparoscopic cholecystectomy. |
topic |
Analgesia bupivacaine cholecystectomy dexmedetomidine intraperitoneal intravenous |
url |
http://www.ijaweb.org/article.asp?issn=0019-5049;year=2019;volume=63;issue=2;spage=106;epage=113;aulast=Chilkoti |
work_keys_str_mv |
AT geetanjalitoliachilkoti comparisonofpostoperativeanalgesicefficacyoflowdosebolusintravenousdexmedetomidineandintraperitonealdexmedetomidinewithbupivacaineinpatientsundergoinglaparoscopiccholecystectomyarandomisedcontrolledtrial AT manishkumar comparisonofpostoperativeanalgesicefficacyoflowdosebolusintravenousdexmedetomidineandintraperitonealdexmedetomidinewithbupivacaineinpatientsundergoinglaparoscopiccholecystectomyarandomisedcontrolledtrial AT medhamohta comparisonofpostoperativeanalgesicefficacyoflowdosebolusintravenousdexmedetomidineandintraperitonealdexmedetomidinewithbupivacaineinpatientsundergoinglaparoscopiccholecystectomyarandomisedcontrolledtrial AT ashokkumarsaxena comparisonofpostoperativeanalgesicefficacyoflowdosebolusintravenousdexmedetomidineandintraperitonealdexmedetomidinewithbupivacaineinpatientsundergoinglaparoscopiccholecystectomyarandomisedcontrolledtrial AT naveensharma comparisonofpostoperativeanalgesicefficacyoflowdosebolusintravenousdexmedetomidineandintraperitonealdexmedetomidinewithbupivacaineinpatientsundergoinglaparoscopiccholecystectomyarandomisedcontrolledtrial AT jitendersingh comparisonofpostoperativeanalgesicefficacyoflowdosebolusintravenousdexmedetomidineandintraperitonealdexmedetomidinewithbupivacaineinpatientsundergoinglaparoscopiccholecystectomyarandomisedcontrolledtrial |
_version_ |
1724997329975508992 |