Structure-based virtual screening identifies an 8-hydroxyquinoline as a small molecule GLI1 inhibitor
The glioma-associated family of transcription factors (GLI) have emerged as a promising therapeutic target for a variety of human cancers. In particular, GLI1 plays a central role as a transcriptional regulator for multiple oncogenic signaling pathways, including the hedgehog (Hh) signaling pathway....
Main Authors: | Radha Charan Dash, Jiachen Wen, Angela M. Zaino, Shana R. Morel, Lianne Q. Chau, Robert J. Wechsler-Reya, M. Kyle Hadden |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2021-03-01
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Series: | Molecular Therapy: Oncolytics |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2372770521000048 |
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