Lacrimal sac adenocarcinoma managed with androgen deprivation
Purpose: To describe a case of primary lacrimal sac adenocarcinoma treated primarily with androgen deprivation therapy (ADT) with good clinic response. Observations: An 82-year-old male presented with a painless right orbital mass. Pathology following partial resection was consistent with primary la...
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2020-09-01
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doaj-34f9a3605bcd438d8ad866406101e6d22020-11-25T03:35:00ZengElsevierAmerican Journal of Ophthalmology Case Reports2451-99362020-09-0119100607Lacrimal sac adenocarcinoma managed with androgen deprivationDavid H. Abramson0Julia Fallon1Noa Biran2Jasmine H. Francis3Korey Jaben4William K. Oh5Department of Surgery, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY, 10065, USA; Corresponding author. 1275 York Avenue, New York, NY, 10065, USA.Department of Medicine, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY, 10065, USAJohn Theurer Cancer Center, Hackensack University Medical Center, 30 Prospect Avenue, Hackensack, NJ, 07601, USADepartment of Surgery, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY, 10065, USADepartment of Surgery, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY, 10065, USADivision of Hematology and Medical Oncology, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place, New York, NY, 10029, USAPurpose: To describe a case of primary lacrimal sac adenocarcinoma treated primarily with androgen deprivation therapy (ADT) with good clinic response. Observations: An 82-year-old male presented with a painless right orbital mass. Pathology following partial resection was consistent with primary lacrimal sac adenocarcinoma positive for androgen receptors (AR). Magnetic resonance imaging (MRI) scan showed an orbital mass with extension into the nasolacrimal apparatus and intraconally between the medial and inferior recti. Staging positron emission tomography/computed tomography (PET/CT) showed one hypermetabolic right sided lymph node in addition to the known orbital mass. Orbital exenteration and external beam radiation therapy were offered as the primary treatment modality however the patient refused. He subsequently received four years of androgen deprivation monotherapy, before stopping due to sexual side effects, with no progression of local or metastatic disease and some local regression documented on MRI at 5 years. Conclusions and Importance: Lacrimal sac adenocarcinoma is commonly found to be AR positive on pathology. Our case shows that ADT can serve as an effective treatment modality for those patients that defer primary surgical management.http://www.sciencedirect.com/science/article/pii/S2451993619300507Lacrimal sac adenocarcinomaAndrogen deprivation therapyAndrogen receptor |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
David H. Abramson Julia Fallon Noa Biran Jasmine H. Francis Korey Jaben William K. Oh |
spellingShingle |
David H. Abramson Julia Fallon Noa Biran Jasmine H. Francis Korey Jaben William K. Oh Lacrimal sac adenocarcinoma managed with androgen deprivation American Journal of Ophthalmology Case Reports Lacrimal sac adenocarcinoma Androgen deprivation therapy Androgen receptor |
author_facet |
David H. Abramson Julia Fallon Noa Biran Jasmine H. Francis Korey Jaben William K. Oh |
author_sort |
David H. Abramson |
title |
Lacrimal sac adenocarcinoma managed with androgen deprivation |
title_short |
Lacrimal sac adenocarcinoma managed with androgen deprivation |
title_full |
Lacrimal sac adenocarcinoma managed with androgen deprivation |
title_fullStr |
Lacrimal sac adenocarcinoma managed with androgen deprivation |
title_full_unstemmed |
Lacrimal sac adenocarcinoma managed with androgen deprivation |
title_sort |
lacrimal sac adenocarcinoma managed with androgen deprivation |
publisher |
Elsevier |
series |
American Journal of Ophthalmology Case Reports |
issn |
2451-9936 |
publishDate |
2020-09-01 |
description |
Purpose: To describe a case of primary lacrimal sac adenocarcinoma treated primarily with androgen deprivation therapy (ADT) with good clinic response. Observations: An 82-year-old male presented with a painless right orbital mass. Pathology following partial resection was consistent with primary lacrimal sac adenocarcinoma positive for androgen receptors (AR). Magnetic resonance imaging (MRI) scan showed an orbital mass with extension into the nasolacrimal apparatus and intraconally between the medial and inferior recti. Staging positron emission tomography/computed tomography (PET/CT) showed one hypermetabolic right sided lymph node in addition to the known orbital mass. Orbital exenteration and external beam radiation therapy were offered as the primary treatment modality however the patient refused. He subsequently received four years of androgen deprivation monotherapy, before stopping due to sexual side effects, with no progression of local or metastatic disease and some local regression documented on MRI at 5 years. Conclusions and Importance: Lacrimal sac adenocarcinoma is commonly found to be AR positive on pathology. Our case shows that ADT can serve as an effective treatment modality for those patients that defer primary surgical management. |
topic |
Lacrimal sac adenocarcinoma Androgen deprivation therapy Androgen receptor |
url |
http://www.sciencedirect.com/science/article/pii/S2451993619300507 |
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