Diagnostic accuracy of stereotactic brain biopsy for intracranial neoplasia in dogs: Comparison of biopsy, surgical resection, and necropsy specimens
Abstract Background Stereotactic brain biopsy (SBB) is a technique that allows for definitive diagnosis of brain lesions. Little information is available regarding the diagnostic utility of SBB in dogs with intracranial diseases. Objective To investigate the diagnostic accuracy (DA) of SBB in dogs w...
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doaj-350248c1c27d4d93b080583b071623f12020-11-25T02:59:20ZengWileyJournal of Veterinary Internal Medicine0891-66401939-16762019-05-013331384139110.1111/jvim.15500Diagnostic accuracy of stereotactic brain biopsy for intracranial neoplasia in dogs: Comparison of biopsy, surgical resection, and necropsy specimensYukitaka Kani0Thomas E. Cecere1Kevin Lahmers2Tanya LeRoith3Kurt L. Zimmerman4Scott Isom5Fang‐Chi Hsu6Waldemar Debinksi7John L. Robertson8John H. Rossmeisl9Veterinary and Comparative Neuro‐oncology Laboratory, Department of Small Animal Clinical Sciences Virginia Tech Blacksburg VirginiaDepartment of Biomedical Sciences and Pathobiology, Virginia‐Maryland College of Veterinary Medicine Virginia Tech Blacksburg VirginiaDepartment of Biomedical Sciences and Pathobiology, Virginia‐Maryland College of Veterinary Medicine Virginia Tech Blacksburg VirginiaDepartment of Biomedical Sciences and Pathobiology, Virginia‐Maryland College of Veterinary Medicine Virginia Tech Blacksburg VirginiaDepartment of Biomedical Sciences and Pathobiology, Virginia‐Maryland College of Veterinary Medicine Virginia Tech Blacksburg VirginiaDepartment of Biostatistical Sciences Wake Forest University Winston‐Salem North CarolinaDepartment of Biostatistical Sciences Wake Forest University Winston‐Salem North CarolinaCancer Biology, Comprehensive Cancer Center and Brain Tumor Center of Excellence, School of Medicine Wake Forest University Winston‐Salem North CarolinaVeterinary and Comparative Neuro‐oncology Laboratory, Department of Small Animal Clinical Sciences Virginia Tech Blacksburg VirginiaVeterinary and Comparative Neuro‐oncology Laboratory, Department of Small Animal Clinical Sciences Virginia Tech Blacksburg VirginiaAbstract Background Stereotactic brain biopsy (SBB) is a technique that allows for definitive diagnosis of brain lesions. Little information is available regarding the diagnostic utility of SBB in dogs with intracranial diseases. Objective To investigate the diagnostic accuracy (DA) of SBB in dogs with brain tumors. Animals Thirty‐one client‐owned dogs that underwent SBB followed by surgical resection or necropsy examinations. Methods Retrospective observational study. Two pathologists blinded to SBB and reference standard diagnoses reviewed histologic specimens and typed and graded tumors according to World Health Organization and revised canine glioma classification criteria. Agreement between tumor type and grade from SBB were compared to reference standards and assessed using kappa statistics. Patient and technical factors associated with agreement also were examined. Results Stereotactic brain biopsy specimens were obtained from 24 dogs with gliomas and 7 with meningiomas. Tumor type agreement between SBB and the reference standard was observed in 30/31 cases (κ = 0.95). Diagnostic concordance was perfect for meningiomas. Grade agreement among gliomas was observed in 18/23 cases (κ = 0.47). Stereotactic brain biopsy underrepresented the reference standard glioma grade in cases with disagreement. The DA of SBB was 81%, with agreement noted in 56/69 biopsy samples. Smaller tumors and fewer SBB specimens obtained were significantly associated with diagnostic discordance. Conclusions and Clinical Importance The DA of SBB readily allows for the diagnosis of common brain tumors in dogs. Although glioma grade discordance was frequent, diagnoses obtained from SBB are sufficient to currently inform therapeutic decisions. Multiple SBB specimens should be collected to maximize DA.https://doi.org/10.1111/jvim.15500biopsybrain tumordiagnosisdoggliomameningioma |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yukitaka Kani Thomas E. Cecere Kevin Lahmers Tanya LeRoith Kurt L. Zimmerman Scott Isom Fang‐Chi Hsu Waldemar Debinksi John L. Robertson John H. Rossmeisl |
spellingShingle |
Yukitaka Kani Thomas E. Cecere Kevin Lahmers Tanya LeRoith Kurt L. Zimmerman Scott Isom Fang‐Chi Hsu Waldemar Debinksi John L. Robertson John H. Rossmeisl Diagnostic accuracy of stereotactic brain biopsy for intracranial neoplasia in dogs: Comparison of biopsy, surgical resection, and necropsy specimens Journal of Veterinary Internal Medicine biopsy brain tumor diagnosis dog glioma meningioma |
author_facet |
Yukitaka Kani Thomas E. Cecere Kevin Lahmers Tanya LeRoith Kurt L. Zimmerman Scott Isom Fang‐Chi Hsu Waldemar Debinksi John L. Robertson John H. Rossmeisl |
author_sort |
Yukitaka Kani |
title |
Diagnostic accuracy of stereotactic brain biopsy for intracranial neoplasia in dogs: Comparison of biopsy, surgical resection, and necropsy specimens |
title_short |
Diagnostic accuracy of stereotactic brain biopsy for intracranial neoplasia in dogs: Comparison of biopsy, surgical resection, and necropsy specimens |
title_full |
Diagnostic accuracy of stereotactic brain biopsy for intracranial neoplasia in dogs: Comparison of biopsy, surgical resection, and necropsy specimens |
title_fullStr |
Diagnostic accuracy of stereotactic brain biopsy for intracranial neoplasia in dogs: Comparison of biopsy, surgical resection, and necropsy specimens |
title_full_unstemmed |
Diagnostic accuracy of stereotactic brain biopsy for intracranial neoplasia in dogs: Comparison of biopsy, surgical resection, and necropsy specimens |
title_sort |
diagnostic accuracy of stereotactic brain biopsy for intracranial neoplasia in dogs: comparison of biopsy, surgical resection, and necropsy specimens |
publisher |
Wiley |
series |
Journal of Veterinary Internal Medicine |
issn |
0891-6640 1939-1676 |
publishDate |
2019-05-01 |
description |
Abstract Background Stereotactic brain biopsy (SBB) is a technique that allows for definitive diagnosis of brain lesions. Little information is available regarding the diagnostic utility of SBB in dogs with intracranial diseases. Objective To investigate the diagnostic accuracy (DA) of SBB in dogs with brain tumors. Animals Thirty‐one client‐owned dogs that underwent SBB followed by surgical resection or necropsy examinations. Methods Retrospective observational study. Two pathologists blinded to SBB and reference standard diagnoses reviewed histologic specimens and typed and graded tumors according to World Health Organization and revised canine glioma classification criteria. Agreement between tumor type and grade from SBB were compared to reference standards and assessed using kappa statistics. Patient and technical factors associated with agreement also were examined. Results Stereotactic brain biopsy specimens were obtained from 24 dogs with gliomas and 7 with meningiomas. Tumor type agreement between SBB and the reference standard was observed in 30/31 cases (κ = 0.95). Diagnostic concordance was perfect for meningiomas. Grade agreement among gliomas was observed in 18/23 cases (κ = 0.47). Stereotactic brain biopsy underrepresented the reference standard glioma grade in cases with disagreement. The DA of SBB was 81%, with agreement noted in 56/69 biopsy samples. Smaller tumors and fewer SBB specimens obtained were significantly associated with diagnostic discordance. Conclusions and Clinical Importance The DA of SBB readily allows for the diagnosis of common brain tumors in dogs. Although glioma grade discordance was frequent, diagnoses obtained from SBB are sufficient to currently inform therapeutic decisions. Multiple SBB specimens should be collected to maximize DA. |
topic |
biopsy brain tumor diagnosis dog glioma meningioma |
url |
https://doi.org/10.1111/jvim.15500 |
work_keys_str_mv |
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