Doxycycline and Tigecycline: Two Friendly Drugs with a Low Association with Clostridium Difficile Infection
Clostridium difficile infection (CDI) is known to be associated with prior exposure to many classes of antibiotics. Standard therapy for CDI (i.e., metronidazole and vancomycin) is associated with high recurrence rates. Although tetracycline derivatives such as tetracycline, doxycycline or tigecycli...
Main Authors: | , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2015-06-01
|
Series: | Antibiotics |
Subjects: | |
Online Access: | http://www.mdpi.com/2079-6382/4/2/216 |
id |
doaj-35055208cd3a42ce9f1780b03b20b3c9 |
---|---|
record_format |
Article |
spelling |
doaj-35055208cd3a42ce9f1780b03b20b3c92020-11-24T22:05:06ZengMDPI AGAntibiotics2079-63822015-06-014221622910.3390/antibiotics4020216antibiotics4020216Doxycycline and Tigecycline: Two Friendly Drugs with a Low Association with Clostridium Difficile InfectionYuan-Pin Hung0Jen-Chieh Lee1Hsiao-Ju Lin2Hsiao-Chieh Liu3Yi-Hui Wu4Pei-Jane Tsai5Wen-Chien Ko6Department of Internal Medicine, Tainan Hospital, Ministry of Health and Welfare, Tainan 70043, TaiwanDepartment of Internal Medicine, National Cheng Kung University Hospital, No. 138, Sheng Li Road, Tainan 70403, TaiwanDepartment of Internal Medicine, Tainan Hospital, Ministry of Health and Welfare, Tainan 70043, TaiwanDepartment of Internal Medicine, Tainan Hospital, Ministry of Health and Welfare, Tainan 70043, TaiwanDepartment of Internal Medicine, E-da Hospital, Kaohsiung 82445, TaiwanDepartment of Medical Laboratory Science and Biotechnology, National Cheng Kung University, Medical College, Tainan 70102, TaiwanDepartment of Internal Medicine, National Cheng Kung University Hospital, No. 138, Sheng Li Road, Tainan 70403, TaiwanClostridium difficile infection (CDI) is known to be associated with prior exposure to many classes of antibiotics. Standard therapy for CDI (i.e., metronidazole and vancomycin) is associated with high recurrence rates. Although tetracycline derivatives such as tetracycline, doxycycline or tigecycline are not the standard therapeutic choices for CDI, they may serve as an alternative or a component of combination therapy. Previous tetracycline or doxycycline usage had been shown to have less association with CDI development. Tigecycline, a broad-spectrum glycylcycline with potency against many gram-positive or gram-negative pathogens, had been successfully used to treat severe or refractory CDI. The in vitro susceptibility of C. difficile clinical isolates to tigecycline in many studies showed low minimal inhibitory concentrations. Tigecycline can suppress in vitro toxin production in both historical and hypervirulent C. difficile strains and reduce spore production in a dose-dependent manner. Tetracycline compounds such as doxycycline, minocycline, and tigecycline possess anti-inflammatory properties that are independent of their antibiotic activity and may contribute to their therapeutic effect for CDI. Although clinical data are limited, doxycycline is less likely to induce CDI, and tigecycline can be considered one of the therapeutic choices for severe or refractory CDI.http://www.mdpi.com/2079-6382/4/2/216Clostridium difficiledoxycyclinetigecycline |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yuan-Pin Hung Jen-Chieh Lee Hsiao-Ju Lin Hsiao-Chieh Liu Yi-Hui Wu Pei-Jane Tsai Wen-Chien Ko |
spellingShingle |
Yuan-Pin Hung Jen-Chieh Lee Hsiao-Ju Lin Hsiao-Chieh Liu Yi-Hui Wu Pei-Jane Tsai Wen-Chien Ko Doxycycline and Tigecycline: Two Friendly Drugs with a Low Association with Clostridium Difficile Infection Antibiotics Clostridium difficile doxycycline tigecycline |
author_facet |
Yuan-Pin Hung Jen-Chieh Lee Hsiao-Ju Lin Hsiao-Chieh Liu Yi-Hui Wu Pei-Jane Tsai Wen-Chien Ko |
author_sort |
Yuan-Pin Hung |
title |
Doxycycline and Tigecycline: Two Friendly Drugs with a Low Association with Clostridium Difficile Infection |
title_short |
Doxycycline and Tigecycline: Two Friendly Drugs with a Low Association with Clostridium Difficile Infection |
title_full |
Doxycycline and Tigecycline: Two Friendly Drugs with a Low Association with Clostridium Difficile Infection |
title_fullStr |
Doxycycline and Tigecycline: Two Friendly Drugs with a Low Association with Clostridium Difficile Infection |
title_full_unstemmed |
Doxycycline and Tigecycline: Two Friendly Drugs with a Low Association with Clostridium Difficile Infection |
title_sort |
doxycycline and tigecycline: two friendly drugs with a low association with clostridium difficile infection |
publisher |
MDPI AG |
series |
Antibiotics |
issn |
2079-6382 |
publishDate |
2015-06-01 |
description |
Clostridium difficile infection (CDI) is known to be associated with prior exposure to many classes of antibiotics. Standard therapy for CDI (i.e., metronidazole and vancomycin) is associated with high recurrence rates. Although tetracycline derivatives such as tetracycline, doxycycline or tigecycline are not the standard therapeutic choices for CDI, they may serve as an alternative or a component of combination therapy. Previous tetracycline or doxycycline usage had been shown to have less association with CDI development. Tigecycline, a broad-spectrum glycylcycline with potency against many gram-positive or gram-negative pathogens, had been successfully used to treat severe or refractory CDI. The in vitro susceptibility of C. difficile clinical isolates to tigecycline in many studies showed low minimal inhibitory concentrations. Tigecycline can suppress in vitro toxin production in both historical and hypervirulent C. difficile strains and reduce spore production in a dose-dependent manner. Tetracycline compounds such as doxycycline, minocycline, and tigecycline possess anti-inflammatory properties that are independent of their antibiotic activity and may contribute to their therapeutic effect for CDI. Although clinical data are limited, doxycycline is less likely to induce CDI, and tigecycline can be considered one of the therapeutic choices for severe or refractory CDI. |
topic |
Clostridium difficile doxycycline tigecycline |
url |
http://www.mdpi.com/2079-6382/4/2/216 |
work_keys_str_mv |
AT yuanpinhung doxycyclineandtigecyclinetwofriendlydrugswithalowassociationwithclostridiumdifficileinfection AT jenchiehlee doxycyclineandtigecyclinetwofriendlydrugswithalowassociationwithclostridiumdifficileinfection AT hsiaojulin doxycyclineandtigecyclinetwofriendlydrugswithalowassociationwithclostridiumdifficileinfection AT hsiaochiehliu doxycyclineandtigecyclinetwofriendlydrugswithalowassociationwithclostridiumdifficileinfection AT yihuiwu doxycyclineandtigecyclinetwofriendlydrugswithalowassociationwithclostridiumdifficileinfection AT peijanetsai doxycyclineandtigecyclinetwofriendlydrugswithalowassociationwithclostridiumdifficileinfection AT wenchienko doxycyclineandtigecyclinetwofriendlydrugswithalowassociationwithclostridiumdifficileinfection |
_version_ |
1725827326060527616 |