Delivery of infection from asymptomatic carriers of COVID-19 in a familial cluster

• Main Authors: Feng Ye, Shicai Xu, Zhihua Rong, Ronghua Xu, Xiaowei Liu, Pingfu Deng, Hai Liu, Xuejun Xu
• Format: Article
• Language: English
• Published: Elsevier 2020-05-01
• Series: International Journal of Infectious Diseases
• Subjects: COVID-19; SARS-CoV-2; Asymptomatic carrier; Incubation period; Pneumonia
• Online Access: http://www.sciencedirect.com/science/article/pii/S1201971220301740

Objectives: With the ongoing outbreak of COVID-19 around the world, it has become a worldwide health concern. One previous study reported a family cluster with an asymptomatic transmission of COVID-19. Here, we report another series of cases and further demonstrate the repeatability of the transmission of COVID-19 by pre-symptomatic carriers. Methods: A familial cluster of five patients associated with COVID-19 was enrolled in the hospital. We collected epidemiological and clinical characteristics, laboratory outcomes from electronic medical records, and also verified them with the patients and their families. Results: Among them, three family members (Case 3/4/5) had returned from Wuhan. Additionally, two family members, those who had not traveled to Wuhan, also contracted COVID-19 after contacting with the other three family members. Case 1 developed severe pneumonia and was admitted to the ICU. Case 3 and Case 5 presented fever and cough on days two through three of hospitalization and had ground-glass opacity changes in their lungs. Case 4 presented with diarrhea and pharyngalgia after admission without radiographic abnormalities. Case 2 presented no clinical nor radiographic abnormalities. All five cases had an increasing level of C-reactive protein. Conclusions: Our findings indicate that COVID-19 can be transmitted by asymptomatic carriers during the incubation period.