Suberoylanilide Hydroxamic Acid, A Histone Deacetylase Inhibitor, Attenuates Postoperative Cognitive Dysfunction in Aging Mice

Suberoylanilide Hydroxamic Acid, A Histone Deacetylase Inhibitor, Attenuates Postoperative Cognitive Dysfunction in Aging Mice

Postoperative cognitive dysfunction (POCD) is a recognized clinical entity characterized with cognitive deficits after anesthesia and surgery, especially in aged patients. Previous studies have shown that histone acetylation plays a key role in hippocampal synaptic plasticity and memory formation. H...

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Bibliographic Details
Main Authors: Min eJia, Wen-Xue eLiu, He-Liang eSun, Yan-Qing eChang, Jiao-Jiao eYang, Mu-Huo eJi, Jian-Jun eYang, Chen-Zhuo eFeng
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-09-01
Series:Frontiers in Molecular Neuroscience
Subjects:
Aging
synaptic plasticity
histone acetylation
neuroapoptosis
postoperative cognitive dysfunction
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnmol.2015.00052/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fnmol.2015.00052/full

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