Robust and flexible platform for directed evolution of yeast genetic switches

Robust and flexible platform for directed evolution of yeast genetic switches

Eukaryotic genetic switches are more complex than prokaryotic ones, complicating their design. Here the authors present a workflow for parallel screening, selection and evolution of yeast genetic switches.

Bibliographic Details
Main Authors: Masahiro Tominaga, Kenta Nozaki, Daisuke Umeno, Jun Ishii, Akihiko Kondo
Format: Article
Language:English
Published: Nature Publishing Group 2021-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-22134-y
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spelling doaj-3522a0a8de284a4c85646d76fb5876fa2021-03-28T11:12:13ZengNature Publishing GroupNature Communications2041-17232021-03-0112111310.1038/s41467-021-22134-yRobust and flexible platform for directed evolution of yeast genetic switchesMasahiro Tominaga0Kenta Nozaki1Daisuke Umeno2Jun Ishii3Akihiko Kondo4Graduate School of Science, Technology and Innovation, Kobe UniversityGraduate School of Science, Technology and Innovation, Kobe UniversityDepartment of Applied Chemistry and Biotechnology, Faculty of Engineering, Chiba UniversityGraduate School of Science, Technology and Innovation, Kobe UniversityGraduate School of Science, Technology and Innovation, Kobe UniversityEukaryotic genetic switches are more complex than prokaryotic ones, complicating their design. Here the authors present a workflow for parallel screening, selection and evolution of yeast genetic switches.https://doi.org/10.1038/s41467-021-22134-y
collection DOAJ
language English
format Article
sources DOAJ
author Masahiro Tominaga
Kenta Nozaki
Daisuke Umeno
Jun Ishii
Akihiko Kondo
spellingShingle Masahiro Tominaga
Kenta Nozaki
Daisuke Umeno
Jun Ishii
Akihiko Kondo
Robust and flexible platform for directed evolution of yeast genetic switches
Nature Communications
author_facet Masahiro Tominaga
Kenta Nozaki
Daisuke Umeno
Jun Ishii
Akihiko Kondo
author_sort Masahiro Tominaga
title Robust and flexible platform for directed evolution of yeast genetic switches
title_short Robust and flexible platform for directed evolution of yeast genetic switches
title_full Robust and flexible platform for directed evolution of yeast genetic switches
title_fullStr Robust and flexible platform for directed evolution of yeast genetic switches
title_full_unstemmed Robust and flexible platform for directed evolution of yeast genetic switches
title_sort robust and flexible platform for directed evolution of yeast genetic switches
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2021-03-01
description Eukaryotic genetic switches are more complex than prokaryotic ones, complicating their design. Here the authors present a workflow for parallel screening, selection and evolution of yeast genetic switches.
url https://doi.org/10.1038/s41467-021-22134-y
work_keys_str_mv AT masahirotominaga robustandflexibleplatformfordirectedevolutionofyeastgeneticswitches
AT kentanozaki robustandflexibleplatformfordirectedevolutionofyeastgeneticswitches
AT daisukeumeno robustandflexibleplatformfordirectedevolutionofyeastgeneticswitches
AT junishii robustandflexibleplatformfordirectedevolutionofyeastgeneticswitches
AT akihikokondo robustandflexibleplatformfordirectedevolutionofyeastgeneticswitches
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