The Long Non-coding RNA MEG3/miR-let-7c-5p Axis Regulates Ethanol-Induced Hepatic Steatosis and Apoptosis by Targeting NLRC5

The Long Non-coding RNA MEG3/miR-let-7c-5p Axis Regulates Ethanol-Induced Hepatic Steatosis and Apoptosis by Targeting NLRC5

Ethanol (EtOH)-induced hepatic injury, characterized by hepatic steatosis with apoptosis, causes heavy health burden personally and socially. Long non-coding RNAs (lncRNAs) have been implicated in liver diseases. However, the role of lncRNA maternally expressed gene 3 (MEG3) in EtOH-induced hepatic...

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Bibliographic Details
Main Authors: Qin Wang, Mingfang Li, Zhiming Shen, Fangtian Bu, Haixia Yu, Xueyin Pan, Yang Yang, Xiaoming Meng, Cheng Huang, Jun Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-04-01
Series:Frontiers in Pharmacology
Subjects:
lncRNA
MEG3
hepatic steatosis
apoptosis
miR-let-7c-5p
NLRC5
Online Access:http://journal.frontiersin.org/article/10.3389/fphar.2018.00302/full

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