Amphetamine Modulation of Long-Term Object Recognition Memory in Rats: Influence of Stress
Amphetamine is a potent psychostimulant that increases brain monoamine levels. Extensive evidence demonstrated that norepinephrine is crucially involved in the regulation of memory consolidation for stressful experiences. Here, we investigated amphetamine effects on the consolidation of long-term re...
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doaj-35364ba6e57643208aa9bd6602dcc7222021-02-24T05:26:04ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122021-02-011210.3389/fphar.2021.644521644521Amphetamine Modulation of Long-Term Object Recognition Memory in Rats: Influence of StressPaola Colucci0Paola Colucci1Alessia Santori2Alessia Santori3Luca Romanelli4Clemens Zwergel5Antonello Mai6Sergio Scaccianoce7Patrizia Campolongo8Patrizia Campolongo9Dept. of Physiology and Pharmacology, Sapienza University of Rome, Rome, ItalyNeurobiology of Behavior Laboratory, Section of Neuropsychopharmacology, IRCCS Santa Lucia Foundation, Rome, ItalyDept. of Physiology and Pharmacology, Sapienza University of Rome, Rome, ItalyNeurobiology of Behavior Laboratory, Section of Neuropsychopharmacology, IRCCS Santa Lucia Foundation, Rome, ItalyDept. of Physiology and Pharmacology, Sapienza University of Rome, Rome, ItalyDept. of Drug Chemistry & Technologies, Sapienza University of Rome, Rome, ItalyDept. of Drug Chemistry & Technologies, Sapienza University of Rome, Rome, ItalyDept. of Physiology and Pharmacology, Sapienza University of Rome, Rome, ItalyDept. of Physiology and Pharmacology, Sapienza University of Rome, Rome, ItalyNeurobiology of Behavior Laboratory, Section of Neuropsychopharmacology, IRCCS Santa Lucia Foundation, Rome, ItalyAmphetamine is a potent psychostimulant that increases brain monoamine levels. Extensive evidence demonstrated that norepinephrine is crucially involved in the regulation of memory consolidation for stressful experiences. Here, we investigated amphetamine effects on the consolidation of long-term recognition memory in rats exposed to different intensities of forced swim stress immediately after training. Furthermore, we evaluated whether such effects are dependent on the activation of the peripheral adrenergic system. To this aim, male adult Sprague Dawley rats were subjected to an object recognition task and intraperitoneally administered soon after training with amphetamine (0.5 or 1 mg/kg), or its corresponding vehicle. Rats were thereafter exposed to a mild (1 min, 25 ± 1°C) or strong (5 min, 19 ± 1°C) forced swim stress procedure. Recognition memory retention was assessed 24-h after training. Our findings showed that amphetamine enhances the consolidation of memory in rats subjected to mild stress condition, while it impairs long-term memory performance in rats exposed to strong stress. These dichotomic effects is dependent on stress-induced activation of the peripheral adrenergic response.https://www.frontiersin.org/articles/10.3389/fphar.2021.644521/fullmemory consolidationforced swim stressnorepinephrineadrenal medullectomyposttraumatic stress disorder |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Paola Colucci Paola Colucci Alessia Santori Alessia Santori Luca Romanelli Clemens Zwergel Antonello Mai Sergio Scaccianoce Patrizia Campolongo Patrizia Campolongo |
spellingShingle |
Paola Colucci Paola Colucci Alessia Santori Alessia Santori Luca Romanelli Clemens Zwergel Antonello Mai Sergio Scaccianoce Patrizia Campolongo Patrizia Campolongo Amphetamine Modulation of Long-Term Object Recognition Memory in Rats: Influence of Stress Frontiers in Pharmacology memory consolidation forced swim stress norepinephrine adrenal medullectomy posttraumatic stress disorder |
author_facet |
Paola Colucci Paola Colucci Alessia Santori Alessia Santori Luca Romanelli Clemens Zwergel Antonello Mai Sergio Scaccianoce Patrizia Campolongo Patrizia Campolongo |
author_sort |
Paola Colucci |
title |
Amphetamine Modulation of Long-Term Object Recognition Memory in Rats: Influence of Stress |
title_short |
Amphetamine Modulation of Long-Term Object Recognition Memory in Rats: Influence of Stress |
title_full |
Amphetamine Modulation of Long-Term Object Recognition Memory in Rats: Influence of Stress |
title_fullStr |
Amphetamine Modulation of Long-Term Object Recognition Memory in Rats: Influence of Stress |
title_full_unstemmed |
Amphetamine Modulation of Long-Term Object Recognition Memory in Rats: Influence of Stress |
title_sort |
amphetamine modulation of long-term object recognition memory in rats: influence of stress |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Pharmacology |
issn |
1663-9812 |
publishDate |
2021-02-01 |
description |
Amphetamine is a potent psychostimulant that increases brain monoamine levels. Extensive evidence demonstrated that norepinephrine is crucially involved in the regulation of memory consolidation for stressful experiences. Here, we investigated amphetamine effects on the consolidation of long-term recognition memory in rats exposed to different intensities of forced swim stress immediately after training. Furthermore, we evaluated whether such effects are dependent on the activation of the peripheral adrenergic system. To this aim, male adult Sprague Dawley rats were subjected to an object recognition task and intraperitoneally administered soon after training with amphetamine (0.5 or 1 mg/kg), or its corresponding vehicle. Rats were thereafter exposed to a mild (1 min, 25 ± 1°C) or strong (5 min, 19 ± 1°C) forced swim stress procedure. Recognition memory retention was assessed 24-h after training. Our findings showed that amphetamine enhances the consolidation of memory in rats subjected to mild stress condition, while it impairs long-term memory performance in rats exposed to strong stress. These dichotomic effects is dependent on stress-induced activation of the peripheral adrenergic response. |
topic |
memory consolidation forced swim stress norepinephrine adrenal medullectomy posttraumatic stress disorder |
url |
https://www.frontiersin.org/articles/10.3389/fphar.2021.644521/full |
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