The Interaction of Genetic Background and Mutational Effects in Regulation of Mouse Craniofacial Shape

The Interaction of Genetic Background and Mutational Effects in Regulation of Mouse Craniofacial Shape

Inbred genetic background significantly influences the expression of phenotypes associated with known genetic perturbations and can underlie variation in disease severity between individuals with the same mutation. However, the effect of epistatic interactions on the development of complex traits, s...

Full description

Bibliographic Details
Main Authors: Christopher J. Percival, Pauline Marangoni, Vagan Tapaltsyan, Ophir Klein, Benedikt Hallgrímsson
Format: Article
Language:English
Published: Oxford University Press 2017-05-01
Series:G3: Genes, Genomes, Genetics
Subjects:
background effect
epistasis
skull
morphometrics
Sprouty
inbred background
Online Access:http://g3journal.org/lookup/doi/10.1534/g3.117.040659

Internet

http://g3journal.org/lookup/doi/10.1534/g3.117.040659

Similar Items