The Interaction of Genetic Background and Mutational Effects in Regulation of Mouse Craniofacial Shape
Inbred genetic background significantly influences the expression of phenotypes associated with known genetic perturbations and can underlie variation in disease severity between individuals with the same mutation. However, the effect of epistatic interactions on the development of complex traits, s...
Main Authors: | Christopher J. Percival, Pauline Marangoni, Vagan Tapaltsyan, Ophir Klein, Benedikt Hallgrímsson |
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Format: | Article |
Language: | English |
Published: |
Oxford University Press
2017-05-01
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Series: | G3: Genes, Genomes, Genetics |
Subjects: | |
Online Access: | http://g3journal.org/lookup/doi/10.1534/g3.117.040659 |
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