Recent Advances in Multinuclear NMR Spectroscopy for Chiral Recognition of Organic Compounds
Nuclear magnetic resonance (NMR) is a powerful tool for the elucidation of chemical structure and chiral recognition. In the last decade, the number of probes, media, and experiments to analyze chiral environments has rapidly increased. The evaluation of chiral molecules and systems has become a rou...
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doaj-354499ee48554116ba9ae5d753811dd22020-11-24T23:46:42ZengMDPI AGMolecules1420-30492017-02-0122224710.3390/molecules22020247molecules22020247Recent Advances in Multinuclear NMR Spectroscopy for Chiral Recognition of Organic CompoundsMárcio S. Silva0Centro de Ciências Naturais e Humanas—CCNH—Universidade Federal do ABC—UFABC, Av. Dos Estados 5001, 09210-180 Santo André –SP, BrazilNuclear magnetic resonance (NMR) is a powerful tool for the elucidation of chemical structure and chiral recognition. In the last decade, the number of probes, media, and experiments to analyze chiral environments has rapidly increased. The evaluation of chiral molecules and systems has become a routine task in almost all NMR laboratories, allowing for the determination of molecular connectivities and the construction of spatial relationships. Among the features that improve the chiral recognition abilities by NMR is the application of different nuclei. The simplicity of the multinuclear NMR spectra relative to 1H, the minimal influence of the experimental conditions, and the larger shift dispersion make these nuclei especially suitable for NMR analysis. Herein, the recent advances in multinuclear (19F, 31P, 13C, and 77Se) NMR spectroscopy for chiral recognition of organic compounds are presented. The review describes new chiral derivatizing agents and chiral solvating agents used for stereodiscrimination and the assignment of the absolute configuration of small organic compounds.http://www.mdpi.com/1420-3049/22/2/247chiral recognitionNMR spectroscopychiralitymultinuclearenantiopurityenantiomeric excessstereochemistryabsolute configuration |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Márcio S. Silva |
spellingShingle |
Márcio S. Silva Recent Advances in Multinuclear NMR Spectroscopy for Chiral Recognition of Organic Compounds Molecules chiral recognition NMR spectroscopy chirality multinuclear enantiopurity enantiomeric excess stereochemistry absolute configuration |
author_facet |
Márcio S. Silva |
author_sort |
Márcio S. Silva |
title |
Recent Advances in Multinuclear NMR Spectroscopy for Chiral Recognition of Organic Compounds |
title_short |
Recent Advances in Multinuclear NMR Spectroscopy for Chiral Recognition of Organic Compounds |
title_full |
Recent Advances in Multinuclear NMR Spectroscopy for Chiral Recognition of Organic Compounds |
title_fullStr |
Recent Advances in Multinuclear NMR Spectroscopy for Chiral Recognition of Organic Compounds |
title_full_unstemmed |
Recent Advances in Multinuclear NMR Spectroscopy for Chiral Recognition of Organic Compounds |
title_sort |
recent advances in multinuclear nmr spectroscopy for chiral recognition of organic compounds |
publisher |
MDPI AG |
series |
Molecules |
issn |
1420-3049 |
publishDate |
2017-02-01 |
description |
Nuclear magnetic resonance (NMR) is a powerful tool for the elucidation of chemical structure and chiral recognition. In the last decade, the number of probes, media, and experiments to analyze chiral environments has rapidly increased. The evaluation of chiral molecules and systems has become a routine task in almost all NMR laboratories, allowing for the determination of molecular connectivities and the construction of spatial relationships. Among the features that improve the chiral recognition abilities by NMR is the application of different nuclei. The simplicity of the multinuclear NMR spectra relative to 1H, the minimal influence of the experimental conditions, and the larger shift dispersion make these nuclei especially suitable for NMR analysis. Herein, the recent advances in multinuclear (19F, 31P, 13C, and 77Se) NMR spectroscopy for chiral recognition of organic compounds are presented. The review describes new chiral derivatizing agents and chiral solvating agents used for stereodiscrimination and the assignment of the absolute configuration of small organic compounds. |
topic |
chiral recognition NMR spectroscopy chirality multinuclear enantiopurity enantiomeric excess stereochemistry absolute configuration |
url |
http://www.mdpi.com/1420-3049/22/2/247 |
work_keys_str_mv |
AT marciossilva recentadvancesinmultinuclearnmrspectroscopyforchiralrecognitionoforganiccompounds |
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1725492778593419264 |