Health-Related Quality of Life and the Relationship to Treatment Satisfaction in Patients with Multiple Sclerosis: Insights from a Large Observational Study
Dirk Schriefer,1 Rocco Haase,1 Jennifer S Kullmann,2 Tjalf Ziemssen1 1University Clinic Carl Gustav Carus Dresden, Center of Clinical Neuroscience, Dresden, Germany; 2Sanofi-Aventis Deutschland GmbH, Neu-Isenburg, GermanyCorrespondence: Tjalf Ziemssen Tel +49-351-458-4465Fax +49-351-458-5717Email tj...
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doaj-35476fa0f1304ffa9ceba7b91291f6412020-11-25T03:21:56ZengDove Medical PressPatient Preference and Adherence1177-889X2020-05-01Volume 1486988054014Health-Related Quality of Life and the Relationship to Treatment Satisfaction in Patients with Multiple Sclerosis: Insights from a Large Observational StudySchriefer DHaase RKullmann JSZiemssen TDirk Schriefer,1 Rocco Haase,1 Jennifer S Kullmann,2 Tjalf Ziemssen1 1University Clinic Carl Gustav Carus Dresden, Center of Clinical Neuroscience, Dresden, Germany; 2Sanofi-Aventis Deutschland GmbH, Neu-Isenburg, GermanyCorrespondence: Tjalf Ziemssen Tel +49-351-458-4465Fax +49-351-458-5717Email tjalf.ziemssen@uniklinikum-dresden.deIntroduction: In patients with multiple sclerosis (MS), fatigue, depression, and physical disability are important determinants that negatively affect health-related quality of life (HRQoL). In studies about MS, HRQoL and treatment satisfaction are emerging endpoints representing the patients’ perspective. However, the association of HRQoL and MS treatment satisfaction has not been evaluated so far.Purpose: Our objective was to evaluate the relationship of different dimensions of HRQoL and treatment satisfaction (effectiveness, side effects, convenience), and to assess which factors of treatment satisfaction, besides disease-related and sociodemographic explanatory factors, can best describe HRQoL.Patients and Methods: We analyzed data from a cross-sectional, observational multicenter study in Germany (THEPA-MS, N=2990 eligible patients for first-line treatment). The instruments used were the SF-36 for HRQoL and the TSQM for treatment satisfaction. Correlation analyses, classification and regression trees and multivariate linear regression with the least absolute shrinkage and selection operator (LASSO) for global variable selection were used to analyze explanatory factors of HRQoL.Results: The SF-36 physical summary score was 45.49 ± 12.03 and mental component summary score 42.87 ± 12.12, with currently untreated patients (N=250) reporting lower HRQoL than patients under first-line treatment (N=2740) (p< 0.001). Physical disability (standardized beta (b)=0.408) was the strongest cross-sectional predictor for physical health, followed by employment status (b=0.163), age (b=0.159) and treatment satisfaction in terms of side effects (b=0.146) and effectiveness (b=0.137). For the mental summary health dimension, presence of a major depressive episode (b=0.234) had the greatest impact, followed by satisfaction with side effects (b=0.152) and effectiveness (b=0.131).Conclusion: Satisfaction with the effectiveness and side effects of treatment was part of the main independent explanatory variables for mental and physical HRQoL in patients with MS. To improve HRQoL, patients’ needs and satisfaction measures may be integral part of disease management beyond treatment of physical disability, depression or fatigue.Keywords: health-related quality of life, treatment satisfaction, patient-reported outcome, TSQM, SF-36, multiple sclerosishttps://www.dovepress.com/health-related-quality-of-life-and-the-relationship-to-treatment-satis-peer-reviewed-article-PPAhealth-related quality of lifetreatment satisfactionpatient-reported outcometsqmsf-36multiple sclerosis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Schriefer D Haase R Kullmann JS Ziemssen T |
spellingShingle |
Schriefer D Haase R Kullmann JS Ziemssen T Health-Related Quality of Life and the Relationship to Treatment Satisfaction in Patients with Multiple Sclerosis: Insights from a Large Observational Study Patient Preference and Adherence health-related quality of life treatment satisfaction patient-reported outcome tsqm sf-36 multiple sclerosis |
author_facet |
Schriefer D Haase R Kullmann JS Ziemssen T |
author_sort |
Schriefer D |
title |
Health-Related Quality of Life and the Relationship to Treatment Satisfaction in Patients with Multiple Sclerosis: Insights from a Large Observational Study |
title_short |
Health-Related Quality of Life and the Relationship to Treatment Satisfaction in Patients with Multiple Sclerosis: Insights from a Large Observational Study |
title_full |
Health-Related Quality of Life and the Relationship to Treatment Satisfaction in Patients with Multiple Sclerosis: Insights from a Large Observational Study |
title_fullStr |
Health-Related Quality of Life and the Relationship to Treatment Satisfaction in Patients with Multiple Sclerosis: Insights from a Large Observational Study |
title_full_unstemmed |
Health-Related Quality of Life and the Relationship to Treatment Satisfaction in Patients with Multiple Sclerosis: Insights from a Large Observational Study |
title_sort |
health-related quality of life and the relationship to treatment satisfaction in patients with multiple sclerosis: insights from a large observational study |
publisher |
Dove Medical Press |
series |
Patient Preference and Adherence |
issn |
1177-889X |
publishDate |
2020-05-01 |
description |
Dirk Schriefer,1 Rocco Haase,1 Jennifer S Kullmann,2 Tjalf Ziemssen1 1University Clinic Carl Gustav Carus Dresden, Center of Clinical Neuroscience, Dresden, Germany; 2Sanofi-Aventis Deutschland GmbH, Neu-Isenburg, GermanyCorrespondence: Tjalf Ziemssen Tel +49-351-458-4465Fax +49-351-458-5717Email tjalf.ziemssen@uniklinikum-dresden.deIntroduction: In patients with multiple sclerosis (MS), fatigue, depression, and physical disability are important determinants that negatively affect health-related quality of life (HRQoL). In studies about MS, HRQoL and treatment satisfaction are emerging endpoints representing the patients’ perspective. However, the association of HRQoL and MS treatment satisfaction has not been evaluated so far.Purpose: Our objective was to evaluate the relationship of different dimensions of HRQoL and treatment satisfaction (effectiveness, side effects, convenience), and to assess which factors of treatment satisfaction, besides disease-related and sociodemographic explanatory factors, can best describe HRQoL.Patients and Methods: We analyzed data from a cross-sectional, observational multicenter study in Germany (THEPA-MS, N=2990 eligible patients for first-line treatment). The instruments used were the SF-36 for HRQoL and the TSQM for treatment satisfaction. Correlation analyses, classification and regression trees and multivariate linear regression with the least absolute shrinkage and selection operator (LASSO) for global variable selection were used to analyze explanatory factors of HRQoL.Results: The SF-36 physical summary score was 45.49 ± 12.03 and mental component summary score 42.87 ± 12.12, with currently untreated patients (N=250) reporting lower HRQoL than patients under first-line treatment (N=2740) (p< 0.001). Physical disability (standardized beta (b)=0.408) was the strongest cross-sectional predictor for physical health, followed by employment status (b=0.163), age (b=0.159) and treatment satisfaction in terms of side effects (b=0.146) and effectiveness (b=0.137). For the mental summary health dimension, presence of a major depressive episode (b=0.234) had the greatest impact, followed by satisfaction with side effects (b=0.152) and effectiveness (b=0.131).Conclusion: Satisfaction with the effectiveness and side effects of treatment was part of the main independent explanatory variables for mental and physical HRQoL in patients with MS. To improve HRQoL, patients’ needs and satisfaction measures may be integral part of disease management beyond treatment of physical disability, depression or fatigue.Keywords: health-related quality of life, treatment satisfaction, patient-reported outcome, TSQM, SF-36, multiple sclerosis |
topic |
health-related quality of life treatment satisfaction patient-reported outcome tsqm sf-36 multiple sclerosis |
url |
https://www.dovepress.com/health-related-quality-of-life-and-the-relationship-to-treatment-satis-peer-reviewed-article-PPA |
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