Synthesis of β-arylated alkylamides via Pd-catalyzed one-pot installation of a directing group and C(sp3)–H arylation
The synthesis of β-arylated alkylamides via alkyl C–H bond arylation has been realized by means of direct one-pot reactions of acyl chlorides, aryl iodides and 8-aminoquinoline. Depending on the structure of the starting materials, both single and double β-arylated alkylamides could be accessed.
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| Language: | English |
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Beilstein-Institut
2016-06-01
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| Series: | Beilstein Journal of Organic Chemistry |
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| Online Access: | https://doi.org/10.3762/bjoc.12.108 |
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doaj-35479b0d539d49ac8645c2285f7b4d892021-02-02T08:28:38ZengBeilstein-InstitutBeilstein Journal of Organic Chemistry1860-53972016-06-011211122112610.3762/bjoc.12.1081860-5397-12-108Synthesis of β-arylated alkylamides via Pd-catalyzed one-pot installation of a directing group and C(sp3)–H arylationYunyun Liu0Yi Zhang1Xiaoji Cao2Jie-Ping Wan3College of Chemistry and Chemical Engineering, Jiangxi Normal University, Nanchang 330022 P. R. ChinaCollege of Chemistry and Chemical Engineering, Jiangxi Normal University, Nanchang 330022 P. R. ChinaResearch Center of Analysis and Measurement, Zhejiang University of Technology, 18 Chaowang Road, Hangzhou, Zhejiang 310014, P.R. ChinaCollege of Chemistry and Chemical Engineering, Jiangxi Normal University, Nanchang 330022 P. R. ChinaThe synthesis of β-arylated alkylamides via alkyl C–H bond arylation has been realized by means of direct one-pot reactions of acyl chlorides, aryl iodides and 8-aminoquinoline. Depending on the structure of the starting materials, both single and double β-arylated alkylamides could be accessed.https://doi.org/10.3762/bjoc.12.108alkylamidesC–H arylationdirecting groupin situ installationone-pot |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Yunyun Liu Yi Zhang Xiaoji Cao Jie-Ping Wan |
| spellingShingle |
Yunyun Liu Yi Zhang Xiaoji Cao Jie-Ping Wan Synthesis of β-arylated alkylamides via Pd-catalyzed one-pot installation of a directing group and C(sp3)–H arylation Beilstein Journal of Organic Chemistry alkylamides C–H arylation directing group in situ installation one-pot |
| author_facet |
Yunyun Liu Yi Zhang Xiaoji Cao Jie-Ping Wan |
| author_sort |
Yunyun Liu |
| title |
Synthesis of β-arylated alkylamides via Pd-catalyzed one-pot installation of a directing group and C(sp3)–H arylation |
| title_short |
Synthesis of β-arylated alkylamides via Pd-catalyzed one-pot installation of a directing group and C(sp3)–H arylation |
| title_full |
Synthesis of β-arylated alkylamides via Pd-catalyzed one-pot installation of a directing group and C(sp3)–H arylation |
| title_fullStr |
Synthesis of β-arylated alkylamides via Pd-catalyzed one-pot installation of a directing group and C(sp3)–H arylation |
| title_full_unstemmed |
Synthesis of β-arylated alkylamides via Pd-catalyzed one-pot installation of a directing group and C(sp3)–H arylation |
| title_sort |
synthesis of β-arylated alkylamides via pd-catalyzed one-pot installation of a directing group and c(sp3)–h arylation |
| publisher |
Beilstein-Institut |
| series |
Beilstein Journal of Organic Chemistry |
| issn |
1860-5397 |
| publishDate |
2016-06-01 |
| description |
The synthesis of β-arylated alkylamides via alkyl C–H bond arylation has been realized by means of direct one-pot reactions of acyl chlorides, aryl iodides and 8-aminoquinoline. Depending on the structure of the starting materials, both single and double β-arylated alkylamides could be accessed. |
| topic |
alkylamides C–H arylation directing group in situ installation one-pot |
| url |
https://doi.org/10.3762/bjoc.12.108 |
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