Human leukocyte antigen (HLA)-Cw0303, HLA-Cw04, and HLA-Cw07 polymorphisms are associated with susceptibility of rheumatoid arthritis in Chinese Han patients from Southern China

Human leukocyte antigen (HLA)-Cw0303, HLA-Cw04, and HLA-Cw07 polymorphisms are associated with susceptibility of rheumatoid arthritis in Chinese Han patients from Southern China

Objective(s): This study aimed to investigate the association between human leukocyte antigen Cw (HLA-Cw) polymorphisms and rheumatoid arthritis (RA) in Chinese Han patients in the Jiangsu area (Southern China).Materials and Methods: Polymerase chain reaction-sequence specific primers were used to d...

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Main Authors: Chuankun Yang, Chunling Wang, Yan Shi, Li Li
Format: Article
Language:English
Published: Mashhad University of Medical Sciences 2019-06-01
Series:Iranian Journal of Basic Medical Sciences
Subjects:
Anti-citrullinated protein antibodies
HLA antigens
Gene frequency
Polymorphism
Single nucleotide
Arthritis rheumatoid
Online Access:http://ijbms.mums.ac.ir/article_12583_15c1fb0b25122fbb5f1435b5914dc471.pdf
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spelling doaj-3548b56482744a189871eb870840738c2020-11-25T02:33:59ZengMashhad University of Medical SciencesIranian Journal of Basic Medical Sciences 2008-38662008-38742019-06-0122661061610.22038/ijbms.2019.33557.800712583Human leukocyte antigen (HLA)-Cw0303, HLA-Cw04, and HLA-Cw07 polymorphisms are associated with susceptibility of rheumatoid arthritis in Chinese Han patients from Southern ChinaChuankun Yang0Chunling Wang1Yan Shi2Li Li3Department of Immunology Laboratory, Zhongda Hospital, School of medicine, Southeast University, Nanjing, Jiangsu, 210009, ChinaDepartment of Immunology Laboratory, Zhongda Hospital, School of medicine, Southeast University, Nanjing, Jiangsu, 210009, ChinaDepartment of Immunology Laboratory, Zhongda Hospital, School of medicine, Southeast University, Nanjing, Jiangsu, 210009, ChinaDepartment of Immunology Laboratory, Zhongda Hospital, School of medicine, Southeast University, Nanjing, Jiangsu, 210009, ChinaObjective(s): This study aimed to investigate the association between human leukocyte antigen Cw (HLA-Cw) polymorphisms and rheumatoid arthritis (RA) in Chinese Han patients in the Jiangsu area (Southern China).Materials and Methods: Polymerase chain reaction-sequence specific primers were used to detect HLA-Cw01–08 of 201 RA patients and 211 healthy individuals from Zhongda Hospital (China). The allele frequency distribution of HLA-Cw and genotypic differences between the two groups were analyzed.Results: The frequency of HLA-Cw0303 in patients with RA was significantly higher than that in controls, while the frequency of HLA-Cw04 was lower than that in controls (Phttp://ijbms.mums.ac.ir/article_12583_15c1fb0b25122fbb5f1435b5914dc471.pdfAnti-citrullinated protein antibodiesHLA antigensGene frequencyPolymorphismSingle nucleotideArthritis rheumatoid
collection DOAJ
language English
format Article
sources DOAJ
author Chuankun Yang
Chunling Wang
Yan Shi
Li Li
spellingShingle Chuankun Yang
Chunling Wang
Yan Shi
Li Li
Human leukocyte antigen (HLA)-Cw0303, HLA-Cw04, and HLA-Cw07 polymorphisms are associated with susceptibility of rheumatoid arthritis in Chinese Han patients from Southern China
Iranian Journal of Basic Medical Sciences
Anti-citrullinated protein antibodies
HLA antigens
Gene frequency
Polymorphism
Single nucleotide
Arthritis rheumatoid
author_facet Chuankun Yang
Chunling Wang
Yan Shi
Li Li
author_sort Chuankun Yang
title Human leukocyte antigen (HLA)-Cw0303, HLA-Cw04, and HLA-Cw07 polymorphisms are associated with susceptibility of rheumatoid arthritis in Chinese Han patients from Southern China
title_short Human leukocyte antigen (HLA)-Cw0303, HLA-Cw04, and HLA-Cw07 polymorphisms are associated with susceptibility of rheumatoid arthritis in Chinese Han patients from Southern China
title_full Human leukocyte antigen (HLA)-Cw0303, HLA-Cw04, and HLA-Cw07 polymorphisms are associated with susceptibility of rheumatoid arthritis in Chinese Han patients from Southern China
title_fullStr Human leukocyte antigen (HLA)-Cw0303, HLA-Cw04, and HLA-Cw07 polymorphisms are associated with susceptibility of rheumatoid arthritis in Chinese Han patients from Southern China
title_full_unstemmed Human leukocyte antigen (HLA)-Cw0303, HLA-Cw04, and HLA-Cw07 polymorphisms are associated with susceptibility of rheumatoid arthritis in Chinese Han patients from Southern China
title_sort human leukocyte antigen (hla)-cw0303, hla-cw04, and hla-cw07 polymorphisms are associated with susceptibility of rheumatoid arthritis in chinese han patients from southern china
publisher Mashhad University of Medical Sciences
series Iranian Journal of Basic Medical Sciences
issn 2008-3866
2008-3874
publishDate 2019-06-01
description Objective(s): This study aimed to investigate the association between human leukocyte antigen Cw (HLA-Cw) polymorphisms and rheumatoid arthritis (RA) in Chinese Han patients in the Jiangsu area (Southern China).Materials and Methods: Polymerase chain reaction-sequence specific primers were used to detect HLA-Cw01–08 of 201 RA patients and 211 healthy individuals from Zhongda Hospital (China). The allele frequency distribution of HLA-Cw and genotypic differences between the two groups were analyzed.Results: The frequency of HLA-Cw0303 in patients with RA was significantly higher than that in controls, while the frequency of HLA-Cw04 was lower than that in controls (P
topic Anti-citrullinated protein antibodies
HLA antigens
Gene frequency
Polymorphism
Single nucleotide
Arthritis rheumatoid
url http://ijbms.mums.ac.ir/article_12583_15c1fb0b25122fbb5f1435b5914dc471.pdf
work_keys_str_mv AT chuankunyang humanleukocyteantigenhlacw0303hlacw04andhlacw07polymorphismsareassociatedwithsusceptibilityofrheumatoidarthritisinchinesehanpatientsfromsouthernchina
AT chunlingwang humanleukocyteantigenhlacw0303hlacw04andhlacw07polymorphismsareassociatedwithsusceptibilityofrheumatoidarthritisinchinesehanpatientsfromsouthernchina
AT yanshi humanleukocyteantigenhlacw0303hlacw04andhlacw07polymorphismsareassociatedwithsusceptibilityofrheumatoidarthritisinchinesehanpatientsfromsouthernchina
AT lili humanleukocyteantigenhlacw0303hlacw04andhlacw07polymorphismsareassociatedwithsusceptibilityofrheumatoidarthritisinchinesehanpatientsfromsouthernchina
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