Feline pemphigus foliaceus: original case series and a comprehensive literature review
Abstract Background Since the first description of feline pemphigus foliaceus (PF) more than 30 years ago, numerous case reports have been published, while larger case series have remained rare. This large body of information, if extrapolated, could address clinical discrepancies and expand our know...
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doaj-35532bd73bc44460bec902f358cc12e32020-11-25T01:59:05ZengBMCBMC Veterinary Research1746-61482019-01-0115111510.1186/s12917-018-1739-yFeline pemphigus foliaceus: original case series and a comprehensive literature reviewPetra Bizikova0Amanda Burrows1Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State UniversityMurdoch University Veterinary Hospital, School of Veterinary and Biomedical Science, Murdoch UniversityAbstract Background Since the first description of feline pemphigus foliaceus (PF) more than 30 years ago, numerous case reports have been published, while larger case series have remained rare. This large body of information, if extrapolated, could address clinical discrepancies and expand our knowledge about the treatment of feline PF. This manuscript reviews cases of feline PF published between 1950 and 2016 and adds additional 35 original cases to provide further insight into the clinical aspect and treatment outcome of this disease. Results Feline PF, while being a primary acantholytic pustular dermatosis, presents most often with crusts and erosions that predominantly affect the face and feet. More than half of cats with active disease exhibits non-dermatological signs such as lethargy, fever and/or anorexia. The prognosis of feline PF is good as the majority of cats rapidly achieve disease control even with the most basic treatment such as glucocorticoid monotherapy. Most PF-affected cats, however, require long-term treatment and, like other autoimmune diseases, feline PF has a tendency to relapse spontaneously or with treatment changes. Conclusions Therefore, despite the overall good prognosis cats with PF can be given, owners should be informed and prepared for these circumstances, which may reduce the risk of euthanasia in the case of disease relapse, and improve treatment compliance.http://link.springer.com/article/10.1186/s12917-018-1739-yAuto-immune skin diseasesAuto-immunityFelineCatDermatologyPemphigus |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Petra Bizikova Amanda Burrows |
spellingShingle |
Petra Bizikova Amanda Burrows Feline pemphigus foliaceus: original case series and a comprehensive literature review BMC Veterinary Research Auto-immune skin diseases Auto-immunity Feline Cat Dermatology Pemphigus |
author_facet |
Petra Bizikova Amanda Burrows |
author_sort |
Petra Bizikova |
title |
Feline pemphigus foliaceus: original case series and a comprehensive literature review |
title_short |
Feline pemphigus foliaceus: original case series and a comprehensive literature review |
title_full |
Feline pemphigus foliaceus: original case series and a comprehensive literature review |
title_fullStr |
Feline pemphigus foliaceus: original case series and a comprehensive literature review |
title_full_unstemmed |
Feline pemphigus foliaceus: original case series and a comprehensive literature review |
title_sort |
feline pemphigus foliaceus: original case series and a comprehensive literature review |
publisher |
BMC |
series |
BMC Veterinary Research |
issn |
1746-6148 |
publishDate |
2019-01-01 |
description |
Abstract Background Since the first description of feline pemphigus foliaceus (PF) more than 30 years ago, numerous case reports have been published, while larger case series have remained rare. This large body of information, if extrapolated, could address clinical discrepancies and expand our knowledge about the treatment of feline PF. This manuscript reviews cases of feline PF published between 1950 and 2016 and adds additional 35 original cases to provide further insight into the clinical aspect and treatment outcome of this disease. Results Feline PF, while being a primary acantholytic pustular dermatosis, presents most often with crusts and erosions that predominantly affect the face and feet. More than half of cats with active disease exhibits non-dermatological signs such as lethargy, fever and/or anorexia. The prognosis of feline PF is good as the majority of cats rapidly achieve disease control even with the most basic treatment such as glucocorticoid monotherapy. Most PF-affected cats, however, require long-term treatment and, like other autoimmune diseases, feline PF has a tendency to relapse spontaneously or with treatment changes. Conclusions Therefore, despite the overall good prognosis cats with PF can be given, owners should be informed and prepared for these circumstances, which may reduce the risk of euthanasia in the case of disease relapse, and improve treatment compliance. |
topic |
Auto-immune skin diseases Auto-immunity Feline Cat Dermatology Pemphigus |
url |
http://link.springer.com/article/10.1186/s12917-018-1739-y |
work_keys_str_mv |
AT petrabizikova felinepemphigusfoliaceusoriginalcaseseriesandacomprehensiveliteraturereview AT amandaburrows felinepemphigusfoliaceusoriginalcaseseriesandacomprehensiveliteraturereview |
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