Strategies to Treat Chronic Pain and Strengthen Impaired Descending Noradrenergic Inhibitory System

Strategies to Treat Chronic Pain and Strengthen Impaired Descending Noradrenergic Inhibitory System

Gabapentinoids (gabapentin and pregabalin) and antidepressants (tricyclic antidepressants and serotonin noradrenaline reuptake inhibitors) are often used to treat chronic pain. The descending noradrenergic inhibitory system from the locus coeruleus (LC) to the dorsal horn of the spinal cord plays an...

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Bibliographic Details
Main Authors: Ken-ichiro Hayashida, Hideaki Obata
Format: Article
Language:English
Published: MDPI AG 2019-02-01
Series:International Journal of Molecular Sciences
Subjects:
locus coeruleus
noradrenaline
descending inhibition
spinal cord
α<sub>2</sub>-adrenergic receptors
neuropathic pain
hypersensitivity
rats
Online Access:https://www.mdpi.com/1422-0067/20/4/822

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https://www.mdpi.com/1422-0067/20/4/822

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