MicroRNA roles in beta-catenin pathway

MicroRNA roles in beta-catenin pathway

<p>Abstract</p> <p>β-catenin, a key factor in the Wnt signaling pathway, has essential functions in the regulation of cell growth and differentiation. Aberrant β-catenin signaling has been linked to various disease pathologies, including an important role in tumorigenesis. Here, we...

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Main Authors: Han Lei, Zhang Jun-Xia, Huang Kai, You Yong-Ping, Jiang Tao, Pu Pei-Yu, Kang Chun-Sheng
Format: Article
Language:English
Published: BMC 2010-09-01
Series:Molecular Cancer
Online Access:http://www.molecular-cancer.com/content/9/1/252
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spelling doaj-356f6a1d4fcb40d598ba38630b493c802020-11-25T02:46:15ZengBMCMolecular Cancer1476-45982010-09-019125210.1186/1476-4598-9-252MicroRNA roles in beta-catenin pathwayHan LeiZhang Jun-XiaHuang KaiYou Yong-PingJiang TaoPu Pei-YuKang Chun-Sheng<p>Abstract</p> <p>β-catenin, a key factor in the Wnt signaling pathway, has essential functions in the regulation of cell growth and differentiation. Aberrant β-catenin signaling has been linked to various disease pathologies, including an important role in tumorigenesis. Here, we review the regulation of the Wnt signaling pathway as it relates to β-catenin signaling in tumorigenesis, with particular focus on the role of microRNAs. Finally, we discuss the potential of β-catenin targeted therapeutics for cancer treatment.</p> http://www.molecular-cancer.com/content/9/1/252
collection DOAJ
language English
format Article
sources DOAJ
author Han Lei
Zhang Jun-Xia
Huang Kai
You Yong-Ping
Jiang Tao
Pu Pei-Yu
Kang Chun-Sheng
spellingShingle Han Lei
Zhang Jun-Xia
Huang Kai
You Yong-Ping
Jiang Tao
Pu Pei-Yu
Kang Chun-Sheng
MicroRNA roles in beta-catenin pathway
Molecular Cancer
author_facet Han Lei
Zhang Jun-Xia
Huang Kai
You Yong-Ping
Jiang Tao
Pu Pei-Yu
Kang Chun-Sheng
author_sort Han Lei
title MicroRNA roles in beta-catenin pathway
title_short MicroRNA roles in beta-catenin pathway
title_full MicroRNA roles in beta-catenin pathway
title_fullStr MicroRNA roles in beta-catenin pathway
title_full_unstemmed MicroRNA roles in beta-catenin pathway
title_sort microrna roles in beta-catenin pathway
publisher BMC
series Molecular Cancer
issn 1476-4598
publishDate 2010-09-01
description <p>Abstract</p> <p>β-catenin, a key factor in the Wnt signaling pathway, has essential functions in the regulation of cell growth and differentiation. Aberrant β-catenin signaling has been linked to various disease pathologies, including an important role in tumorigenesis. Here, we review the regulation of the Wnt signaling pathway as it relates to β-catenin signaling in tumorigenesis, with particular focus on the role of microRNAs. Finally, we discuss the potential of β-catenin targeted therapeutics for cancer treatment.</p>
url http://www.molecular-cancer.com/content/9/1/252
work_keys_str_mv AT hanlei micrornarolesinbetacateninpathway
AT zhangjunxia micrornarolesinbetacateninpathway
AT huangkai micrornarolesinbetacateninpathway
AT youyongping micrornarolesinbetacateninpathway
AT jiangtao micrornarolesinbetacateninpathway
AT pupeiyu micrornarolesinbetacateninpathway
AT kangchunsheng micrornarolesinbetacateninpathway
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