Stereoselective property of 20(S)-protopanaxadiol ocotillol type epimers affects its absorption and also the inhibition of P-glycoprotein.
Stereoselectivity has been proved to be tightly related to drug action including pharmacodynamics and pharmacokinetics. (20S,24R)-epoxy-dammarane-3,12,25-triol (24R-epimer) and (20S,24S)-epoxy-dammarane-3,12,25-triol (24S-epimer), a pair of 20(S)-protopanaxadiol (PPD) ocotillol type epimers, were th...
Main Authors: | Wenyan Wang, Xiangmeng Wu, Li Wang, Qingguo Meng, Wanhui Liu |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2014-01-01
|
Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC4041784?pdf=render |
Similar Items
-
Stereoselective regulations of P-glycoprotein by ginsenoside Rh2 epimers and the potential mechanisms from the view of pharmacokinetics.
by: Jingwei Zhang, et al.
Published: (2012-01-01) -
Molecular Insight into Stereoselective ADME Characteristics of C20-24 Epimeric Epoxides of Protopanaxadiol by Docking Analysis
by: Wenna Guo, et al.
Published: (2020-01-01) -
Discovery, semisynthesis, biological activities, and metabolism of ocotillol-type saponins
by: Juan Liu, et al.
Published: (2017-07-01) -
20(S)-protopanaxadiol inhibition of progression and growth of castration-resistant prostate cancer.
by: Bo Cao, et al.
Published: (2014-01-01) -
Anticancer activity of 20(s) protopanaxadiol on cancer cells
by: Zhao, Yan
Published: (2009)