Decay of antibody isotypes against early developmental stages of Schistosoma mansoni after treatment of schistosomiasis patients
Antibodies to a number of parasite antigens are found in schistosomiasis patients, and antibodies to early developmental stages were demonstrated to be efficient immunologic markers for the diagnosis of schistosomiasis. In the present study, decay patterns of IgM and IgG antibodies against cercariae...
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Universidade de São Paulo
1997-09-01
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doaj-3574f2feed3449fba2c3d325ae3bd57e2020-11-25T01:09:23ZengUniversidade de São PauloRevista do Instituto de Medicina Tropical de São Paulo0036-46651678-99461997-09-0139527110.1590/S0036-46651997000500005Decay of antibody isotypes against early developmental stages of Schistosoma mansoni after treatment of schistosomiasis patientsHerminia Yohko KANAMURASumie HOSHINO-SHIMIZURegina Tomie KIMURATokiko Kyomen MATSUMOTOLuiz Caetano da SILVADirce Mary Correa LIMAClarice Pires ABRANTES-LEMOSAntibodies to a number of parasite antigens are found in schistosomiasis patients, and antibodies to early developmental stages were demonstrated to be efficient immunologic markers for the diagnosis of schistosomiasis. In the present study, decay patterns of IgM and IgG antibodies against cercariae and schistosomula were investigated, in comparison to antibodies against worms and eggs in schistosomiasis patients after chemotherapy, for an investigation of seroepidemiologic aspects. Data obtained in the study of 359 serum samples from patients with Schistosoma mansoni infection, noninfected individuals, and patients followed-up for a period of 12 to 15 months after treatment provided the basis to postulate a general pattern for the kinetics of antibody decay. Before treatment, the antibody pattern was represented by a unimodal curve, which shifted to a bimodal curve after treatment, and ended with a unimodal curve similar to that for the noninfected group. Different types of antibodies were classified into four categories according to their decay features, and anti-schistosomulum IgM was classified into the moderate-decay caterogy, whereas other antibodies to early parasite stages were classified into the slow-decay category. The present methodology permits the identification of the most suitable antibodies to be detected in field control programs for schistosomiasis or other parasitoses<br>Em pacientes com esquistossomose, são encontrados anticorpos contra grande número de antígenos parasitários, e aqueles contra formas evolutivas jovens do parasita demonstraram que eram eficientes marcadores imunológicos para o diagnóstico da esquistossomose. Padrões de queda de anticorpos IgM e IgG contra cercária e esquistossômulo foram aqui estudados, comparativamente aos dos anticorpos contra verme e ovo, em pacientes esquistossomóticos após quimioterapia, abordando aspectos soroepidemiológicos. Dados obtidos no estudo de 359 amostras de soros, pertencentes a pacientes infectados por Schistosoma mansoni, indivíduos não infectados e pacientes acompanhados pós-tratamento por um período de 12 a 15 meses, forneceram base para postular padrão geral da cinética de queda de anticorpos. Antes do tratamento, o padrão de anticorpos é representado por curva unimodal, que se modifica para curva bimodal após tratamento, e finaliza com curva unimodal semelhante à do grupo de indivíduos não infectados. Diferentes tipos de anticorpos foram classificados em quatro categorias, conforme características apresentadas na queda, e o anticorpo IgM anti-esquistossômulo foi considerado como pertencente à categoria de anticorpos com queda moderada, enquanto que os demais anticorpos contra formas evolutivas jovens do parasita, à categoria daqueles com queda lenta. A metodologia aqui empregada permite identificar anticorpos potencialmente mais adequados a serem detectados em programas para controle da esquistossomose ou de outras parasitoses no campohttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46651997000500005Schistosomiasis mansoniAntibody decayChemotherapyAnti-cercariaAnti-schistosomulum |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Herminia Yohko KANAMURA Sumie HOSHINO-SHIMIZU Regina Tomie KIMURA Tokiko Kyomen MATSUMOTO Luiz Caetano da SILVA Dirce Mary Correa LIMA Clarice Pires ABRANTES-LEMOS |
spellingShingle |
Herminia Yohko KANAMURA Sumie HOSHINO-SHIMIZU Regina Tomie KIMURA Tokiko Kyomen MATSUMOTO Luiz Caetano da SILVA Dirce Mary Correa LIMA Clarice Pires ABRANTES-LEMOS Decay of antibody isotypes against early developmental stages of Schistosoma mansoni after treatment of schistosomiasis patients Revista do Instituto de Medicina Tropical de São Paulo Schistosomiasis mansoni Antibody decay Chemotherapy Anti-cercaria Anti-schistosomulum |
author_facet |
Herminia Yohko KANAMURA Sumie HOSHINO-SHIMIZU Regina Tomie KIMURA Tokiko Kyomen MATSUMOTO Luiz Caetano da SILVA Dirce Mary Correa LIMA Clarice Pires ABRANTES-LEMOS |
author_sort |
Herminia Yohko KANAMURA |
title |
Decay of antibody isotypes against early developmental stages of Schistosoma mansoni after treatment of schistosomiasis patients |
title_short |
Decay of antibody isotypes against early developmental stages of Schistosoma mansoni after treatment of schistosomiasis patients |
title_full |
Decay of antibody isotypes against early developmental stages of Schistosoma mansoni after treatment of schistosomiasis patients |
title_fullStr |
Decay of antibody isotypes against early developmental stages of Schistosoma mansoni after treatment of schistosomiasis patients |
title_full_unstemmed |
Decay of antibody isotypes against early developmental stages of Schistosoma mansoni after treatment of schistosomiasis patients |
title_sort |
decay of antibody isotypes against early developmental stages of schistosoma mansoni after treatment of schistosomiasis patients |
publisher |
Universidade de São Paulo |
series |
Revista do Instituto de Medicina Tropical de São Paulo |
issn |
0036-4665 1678-9946 |
publishDate |
1997-09-01 |
description |
Antibodies to a number of parasite antigens are found in schistosomiasis patients, and antibodies to early developmental stages were demonstrated to be efficient immunologic markers for the diagnosis of schistosomiasis. In the present study, decay patterns of IgM and IgG antibodies against cercariae and schistosomula were investigated, in comparison to antibodies against worms and eggs in schistosomiasis patients after chemotherapy, for an investigation of seroepidemiologic aspects. Data obtained in the study of 359 serum samples from patients with Schistosoma mansoni infection, noninfected individuals, and patients followed-up for a period of 12 to 15 months after treatment provided the basis to postulate a general pattern for the kinetics of antibody decay. Before treatment, the antibody pattern was represented by a unimodal curve, which shifted to a bimodal curve after treatment, and ended with a unimodal curve similar to that for the noninfected group. Different types of antibodies were classified into four categories according to their decay features, and anti-schistosomulum IgM was classified into the moderate-decay caterogy, whereas other antibodies to early parasite stages were classified into the slow-decay category. The present methodology permits the identification of the most suitable antibodies to be detected in field control programs for schistosomiasis or other parasitoses<br>Em pacientes com esquistossomose, são encontrados anticorpos contra grande número de antígenos parasitários, e aqueles contra formas evolutivas jovens do parasita demonstraram que eram eficientes marcadores imunológicos para o diagnóstico da esquistossomose. Padrões de queda de anticorpos IgM e IgG contra cercária e esquistossômulo foram aqui estudados, comparativamente aos dos anticorpos contra verme e ovo, em pacientes esquistossomóticos após quimioterapia, abordando aspectos soroepidemiológicos. Dados obtidos no estudo de 359 amostras de soros, pertencentes a pacientes infectados por Schistosoma mansoni, indivíduos não infectados e pacientes acompanhados pós-tratamento por um período de 12 a 15 meses, forneceram base para postular padrão geral da cinética de queda de anticorpos. Antes do tratamento, o padrão de anticorpos é representado por curva unimodal, que se modifica para curva bimodal após tratamento, e finaliza com curva unimodal semelhante à do grupo de indivíduos não infectados. Diferentes tipos de anticorpos foram classificados em quatro categorias, conforme características apresentadas na queda, e o anticorpo IgM anti-esquistossômulo foi considerado como pertencente à categoria de anticorpos com queda moderada, enquanto que os demais anticorpos contra formas evolutivas jovens do parasita, à categoria daqueles com queda lenta. A metodologia aqui empregada permite identificar anticorpos potencialmente mais adequados a serem detectados em programas para controle da esquistossomose ou de outras parasitoses no campo |
topic |
Schistosomiasis mansoni Antibody decay Chemotherapy Anti-cercaria Anti-schistosomulum |
url |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46651997000500005 |
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