Targeting Pyrimidine Metabolism in the Era of Precision Cancer Medicine
Metabolic rewiring is considered as a primary feature of cancer. Malignant cells reprogram metabolism pathway in response to various intrinsic and extrinsic drawback to fuel cell survival and growth. Among the complex metabolic pathways, pyrimidine biosynthesis is conserved in all living organism an...
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2021-05-01
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doaj-357ae6288a784d1fb662a955996e1c842021-05-28T08:55:23ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2021-05-011110.3389/fonc.2021.684961684961Targeting Pyrimidine Metabolism in the Era of Precision Cancer MedicineWanyan Wang0Jiayan Cui1Hui Ma2Weiqiang Lu3Jin Huang4State Key Laboratory of Bioreactor Engineering, Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai, ChinaState Key Laboratory of Bioreactor Engineering, Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai, ChinaState Key Laboratory of Bioreactor Engineering, Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai, ChinaShanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, ChinaState Key Laboratory of Bioreactor Engineering, Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai, ChinaMetabolic rewiring is considered as a primary feature of cancer. Malignant cells reprogram metabolism pathway in response to various intrinsic and extrinsic drawback to fuel cell survival and growth. Among the complex metabolic pathways, pyrimidine biosynthesis is conserved in all living organism and is necessary to maintain cellular fundamental function (i.e. DNA and RNA biosynthesis). A wealth of evidence has demonstrated that dysfunction of pyrimidine metabolism is closely related to cancer progression and numerous drugs targeting pyrimidine metabolism have been approved for multiple types of cancer. However, the non-negligible side effects and limited efficacy warrants a better strategy for negating pyrimidine metabolism in cancer. In recent years, increased studies have evidenced the interplay of oncogenic signaling and pyrimidine synthesis in tumorigenesis. Here, we review the recent conceptual advances on pyrimidine metabolism, especially dihydroorotate dehydrogenase (DHODH), in the framework of precision oncology medicine and prospect how this would guide the development of new drug precisely targeting the pyrimidine metabolism in cancer.https://www.frontiersin.org/articles/10.3389/fonc.2021.684961/fullmetabolic reprogrampyrimidine metabolismprecision medicinedihydroorotate dehydrogenasepyrimidine inhibitor |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Wanyan Wang Jiayan Cui Hui Ma Weiqiang Lu Jin Huang |
spellingShingle |
Wanyan Wang Jiayan Cui Hui Ma Weiqiang Lu Jin Huang Targeting Pyrimidine Metabolism in the Era of Precision Cancer Medicine Frontiers in Oncology metabolic reprogram pyrimidine metabolism precision medicine dihydroorotate dehydrogenase pyrimidine inhibitor |
author_facet |
Wanyan Wang Jiayan Cui Hui Ma Weiqiang Lu Jin Huang |
author_sort |
Wanyan Wang |
title |
Targeting Pyrimidine Metabolism in the Era of Precision Cancer Medicine |
title_short |
Targeting Pyrimidine Metabolism in the Era of Precision Cancer Medicine |
title_full |
Targeting Pyrimidine Metabolism in the Era of Precision Cancer Medicine |
title_fullStr |
Targeting Pyrimidine Metabolism in the Era of Precision Cancer Medicine |
title_full_unstemmed |
Targeting Pyrimidine Metabolism in the Era of Precision Cancer Medicine |
title_sort |
targeting pyrimidine metabolism in the era of precision cancer medicine |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Oncology |
issn |
2234-943X |
publishDate |
2021-05-01 |
description |
Metabolic rewiring is considered as a primary feature of cancer. Malignant cells reprogram metabolism pathway in response to various intrinsic and extrinsic drawback to fuel cell survival and growth. Among the complex metabolic pathways, pyrimidine biosynthesis is conserved in all living organism and is necessary to maintain cellular fundamental function (i.e. DNA and RNA biosynthesis). A wealth of evidence has demonstrated that dysfunction of pyrimidine metabolism is closely related to cancer progression and numerous drugs targeting pyrimidine metabolism have been approved for multiple types of cancer. However, the non-negligible side effects and limited efficacy warrants a better strategy for negating pyrimidine metabolism in cancer. In recent years, increased studies have evidenced the interplay of oncogenic signaling and pyrimidine synthesis in tumorigenesis. Here, we review the recent conceptual advances on pyrimidine metabolism, especially dihydroorotate dehydrogenase (DHODH), in the framework of precision oncology medicine and prospect how this would guide the development of new drug precisely targeting the pyrimidine metabolism in cancer. |
topic |
metabolic reprogram pyrimidine metabolism precision medicine dihydroorotate dehydrogenase pyrimidine inhibitor |
url |
https://www.frontiersin.org/articles/10.3389/fonc.2021.684961/full |
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