Voxel-Based Morphometry Reveals a Correlation Between Bone Mineral Density Loss and Reduced Cortical Gray Matter Volume in Alzheimer’s Disease
Background: Decreased bone mineral density (BMD) was associated with poorer cognitive function and increased risk of Alzheimer’s disease (AD). However, objective evidence for the relationship between osteoporosis and AD in humans has not been extensively described.Objectives: We aimed to evaluate th...
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doaj-3581eb4ce60e4999a2ea1e96f602a35a2020-11-25T02:58:19ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652020-06-011210.3389/fnagi.2020.00178541166Voxel-Based Morphometry Reveals a Correlation Between Bone Mineral Density Loss and Reduced Cortical Gray Matter Volume in Alzheimer’s DiseaseYumi Takano0Yumi Takano1Yasuko Tatewaki2Yasuko Tatewaki3Tatsushi Mutoh4Tatsushi Mutoh5Naoya Morota6Izumi Matsudaira7Benjamin Thyreau8Tatsuo Nagasaka9Hayato Odagiri10Shuzo Yamamoto11Shuzo Yamamoto12Hiroyuki Arai13Hiroyuki Arai14Yasuyuki Taki15Yasuyuki Taki16Yasuyuki Taki17Department of Nuclear Medicine and Radiology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, JapanDepartment of Geriatric Medicine and Neuroimaging, Tohoku University Hospital, Sendai, JapanDepartment of Nuclear Medicine and Radiology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, JapanDepartment of Geriatric Medicine and Neuroimaging, Tohoku University Hospital, Sendai, JapanDepartment of Nuclear Medicine and Radiology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, JapanDepartment of Geriatric Medicine and Neuroimaging, Tohoku University Hospital, Sendai, JapanDepartment of Nuclear Medicine and Radiology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, JapanDepartment of Nuclear Medicine and Radiology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, JapanSmart-Aging International Research Center, Tohoku University, Sendai, JapanDivision of Radiology, Tohoku University Hospital, Sendai, JapanDivision of Radiology, Tohoku University Hospital, Sendai, JapanDepartment of Nuclear Medicine and Radiology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, JapanDepartment of Geriatric Medicine and Neuroimaging, Tohoku University Hospital, Sendai, JapanDepartment of Geriatric Medicine and Neuroimaging, Tohoku University Hospital, Sendai, JapanDepartment of Geriatrics and Gerontology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, JapanDepartment of Nuclear Medicine and Radiology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, JapanDepartment of Geriatric Medicine and Neuroimaging, Tohoku University Hospital, Sendai, JapanSmart-Aging International Research Center, Tohoku University, Sendai, JapanBackground: Decreased bone mineral density (BMD) was associated with poorer cognitive function and increased risk of Alzheimer’s disease (AD). However, objective evidence for the relationship between osteoporosis and AD in humans has not been extensively described.Objectives: We aimed to evaluate the relationships between BMD and the cortical volumes of brain regions vulnerable to AD; hippocampus, parahippocampal gyrus, precuneus, posterior cingulate, and angular gyrus, using voxel-based morphometry (VBM), to investigate the association between bone loss and AD.Methods: A cohort of 149 consecutive elderly participants who complained of memory disturbance underwent high-resolution structural brain magnetic resonance imaging (MRI) and dual-energy X-ray absorptiometry (DXA). We used SPM12 software to conduct a voxel-based multiple regression analysis to examine the association between femoral neck BMD values and regional gray matter volume (rGMV) on structural T1-weighted MRI.Results: After adjusting for subject age, gender, total brain volume (TBV), and mini-mental state examination (MMSE) scores, the multiple regression analysis showed significant correlations between BMD loss and rGMV decline in the left precuneus, which is an important neural network hub vulnerable to AD.Conclusion: These data suggest that the bone and brain communicate with each other, as in “bone-brain crosstalk,” and that control of BMD factors could contribute to cognitive function and help prevent AD.https://www.frontiersin.org/article/10.3389/fnagi.2020.00178/fullMRIosteoporosisbone mineral densityAlzheimer’s diseasevoxel-based morphometry |
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DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yumi Takano Yumi Takano Yasuko Tatewaki Yasuko Tatewaki Tatsushi Mutoh Tatsushi Mutoh Naoya Morota Izumi Matsudaira Benjamin Thyreau Tatsuo Nagasaka Hayato Odagiri Shuzo Yamamoto Shuzo Yamamoto Hiroyuki Arai Hiroyuki Arai Yasuyuki Taki Yasuyuki Taki Yasuyuki Taki |
spellingShingle |
Yumi Takano Yumi Takano Yasuko Tatewaki Yasuko Tatewaki Tatsushi Mutoh Tatsushi Mutoh Naoya Morota Izumi Matsudaira Benjamin Thyreau Tatsuo Nagasaka Hayato Odagiri Shuzo Yamamoto Shuzo Yamamoto Hiroyuki Arai Hiroyuki Arai Yasuyuki Taki Yasuyuki Taki Yasuyuki Taki Voxel-Based Morphometry Reveals a Correlation Between Bone Mineral Density Loss and Reduced Cortical Gray Matter Volume in Alzheimer’s Disease Frontiers in Aging Neuroscience MRI osteoporosis bone mineral density Alzheimer’s disease voxel-based morphometry |
author_facet |
Yumi Takano Yumi Takano Yasuko Tatewaki Yasuko Tatewaki Tatsushi Mutoh Tatsushi Mutoh Naoya Morota Izumi Matsudaira Benjamin Thyreau Tatsuo Nagasaka Hayato Odagiri Shuzo Yamamoto Shuzo Yamamoto Hiroyuki Arai Hiroyuki Arai Yasuyuki Taki Yasuyuki Taki Yasuyuki Taki |
author_sort |
Yumi Takano |
title |
Voxel-Based Morphometry Reveals a Correlation Between Bone Mineral Density Loss and Reduced Cortical Gray Matter Volume in Alzheimer’s Disease |
title_short |
Voxel-Based Morphometry Reveals a Correlation Between Bone Mineral Density Loss and Reduced Cortical Gray Matter Volume in Alzheimer’s Disease |
title_full |
Voxel-Based Morphometry Reveals a Correlation Between Bone Mineral Density Loss and Reduced Cortical Gray Matter Volume in Alzheimer’s Disease |
title_fullStr |
Voxel-Based Morphometry Reveals a Correlation Between Bone Mineral Density Loss and Reduced Cortical Gray Matter Volume in Alzheimer’s Disease |
title_full_unstemmed |
Voxel-Based Morphometry Reveals a Correlation Between Bone Mineral Density Loss and Reduced Cortical Gray Matter Volume in Alzheimer’s Disease |
title_sort |
voxel-based morphometry reveals a correlation between bone mineral density loss and reduced cortical gray matter volume in alzheimer’s disease |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Aging Neuroscience |
issn |
1663-4365 |
publishDate |
2020-06-01 |
description |
Background: Decreased bone mineral density (BMD) was associated with poorer cognitive function and increased risk of Alzheimer’s disease (AD). However, objective evidence for the relationship between osteoporosis and AD in humans has not been extensively described.Objectives: We aimed to evaluate the relationships between BMD and the cortical volumes of brain regions vulnerable to AD; hippocampus, parahippocampal gyrus, precuneus, posterior cingulate, and angular gyrus, using voxel-based morphometry (VBM), to investigate the association between bone loss and AD.Methods: A cohort of 149 consecutive elderly participants who complained of memory disturbance underwent high-resolution structural brain magnetic resonance imaging (MRI) and dual-energy X-ray absorptiometry (DXA). We used SPM12 software to conduct a voxel-based multiple regression analysis to examine the association between femoral neck BMD values and regional gray matter volume (rGMV) on structural T1-weighted MRI.Results: After adjusting for subject age, gender, total brain volume (TBV), and mini-mental state examination (MMSE) scores, the multiple regression analysis showed significant correlations between BMD loss and rGMV decline in the left precuneus, which is an important neural network hub vulnerable to AD.Conclusion: These data suggest that the bone and brain communicate with each other, as in “bone-brain crosstalk,” and that control of BMD factors could contribute to cognitive function and help prevent AD. |
topic |
MRI osteoporosis bone mineral density Alzheimer’s disease voxel-based morphometry |
url |
https://www.frontiersin.org/article/10.3389/fnagi.2020.00178/full |
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