The use of protein structure/activity relationships in the rational design of stable particulate delivery systems

The use of protein structure/activity relationships in the rational design of stable particulate delivery systems

The recombinant heat shock protein (18 kDa-hsp) from Mycobacterium leprae was studied as a T-epitope model for vaccine development. We present a structural analysis of the stability of recombinant 18 kDa-hsp during different processing steps. Circular dichroism and ELISA were used to monitor protein...

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Bibliographic Details
Main Authors: M.H.B. Costa, W. Quintilio, O.A. Sant'Anna, A. Faljoni-Alário, P.S. de Araujo
Format: Article
Language:English
Published: Associação Brasileira de Divulgação Científica 2002-06-01
Series:Brazilian Journal of Medical and Biological Research
Subjects:
Protein stability
Hydrophobic modification
Vaccine delivery system
Drug delivery system
Adjuvant
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2002000600014

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2002000600014

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