An Intradermal Inoculation Mouse Model for Immunological Investigations of Acute Scrub Typhus and Persistent Infection.

An Intradermal Inoculation Mouse Model for Immunological Investigations of Acute Scrub Typhus and Persistent Infection.

Scrub typhus is a neglected tropical disease, caused by Orientia tsutsugamushi, a Gram-negative bacterium that is transmitted to mammalian hosts during feeding by Leptotrombidium mites and replicates predominantly within endothelial cells. Most studies of scrub typhus in animal models have utilized...

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Bibliographic Details
Main Authors: Lynn Soong, Nicole L Mendell, Juan P Olano, Dedeke Rockx-Brouwer, Guang Xu, Yenny Goez-Rivillas, Claire Drom, Thomas R Shelite, Gustavo Valbuena, David H Walker, Donald H Bouyer
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-08-01
Series:PLoS Neglected Tropical Diseases
Online Access:http://europepmc.org/articles/PMC4968841?pdf=render

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