The M2 macrophage marker CD206: a novel prognostic indicator for acute myeloid leukemia
Hematological malignancies possess a distinctive immunologic microenvironment compared with solid tumors. Here, using an established computational algorithm (CIBERSORT), we systematically analyzed the overall distribution of 22 tumor-infiltrating leukocyte (TIL) populations in more than 2000 bone ma...
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doaj-3585cdeea2744f8f84fa22b926922fcc2021-09-24T14:41:23ZengTaylor & Francis GroupOncoImmunology2162-402X2020-01-019110.1080/2162402X.2019.16833471683347The M2 macrophage marker CD206: a novel prognostic indicator for acute myeloid leukemiaZi-Jun Xu0Yu Gu1Cui-Zhu Wang2Ye Jin3Xiang-Mei Wen4Ji-Chun Ma5Li-Juan Tang6Zhen-Wei Mao7Jun Qian8Jiang Lin9Affiliated People’s Hospital of Jiangsu UniversityZhenjiang Clinical Research Center of HematologyAffiliated Haian Hospital of Nantong UniversityZhenjiang Clinical Research Center of HematologyAffiliated People’s Hospital of Jiangsu UniversityAffiliated People’s Hospital of Jiangsu UniversityAffiliated People’s Hospital of Jiangsu UniversityThe Key Lab of Precision Diagnosis and Treatment in Hematologic Malignancies of Zhenjiang CityZhenjiang Clinical Research Center of HematologyAffiliated People’s Hospital of Jiangsu UniversityHematological malignancies possess a distinctive immunologic microenvironment compared with solid tumors. Here, using an established computational algorithm (CIBERSORT), we systematically analyzed the overall distribution of 22 tumor-infiltrating leukocyte (TIL) populations in more than 2000 bone marrow (BM) samples from 5 major hematological malignancies and healthy controls. Focusing on significantly altered TILs in acute myeloid leukemia (AML), we found that patients with AML exhibited increased frequencies of M2 macrophages, compared to either healthy controls or the other four malignancies. High infiltration of M2 macrophages was associated with poor outcome in AML. Further analysis revealed that CD206, a M2 marker gene, could faithfully reflect variation in M2 fractions and was more highly expressed in AML than normal controls. High CD206 expression predicted inferior overall survival (OS) and event-free survival (EFS) in two independent AML cohorts. Among 175 patients with intermediate-risk cytogenetics, the survival still differed greatly between low and high CD206 expressers (OS; P < .0001; 3-year rates, 56% v 32%; EFS; P < .001; 3-year rates, 47% v 25%). When analyzed in a meta-analysis, CD206 as a continuous variable showed superior predictive performance than classical prognosticators in AML (BAALC, ERG, EVI1, MN1, and WT1). In summary, M2 macrophages are preferentially enriched in AML. The M2 marker CD206 may serve as a new prognostic marker in AML.http://dx.doi.org/10.1080/2162402X.2019.1683347cd206m2 macrophageacute myeloid leukemiaprognosis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Zi-Jun Xu Yu Gu Cui-Zhu Wang Ye Jin Xiang-Mei Wen Ji-Chun Ma Li-Juan Tang Zhen-Wei Mao Jun Qian Jiang Lin |
spellingShingle |
Zi-Jun Xu Yu Gu Cui-Zhu Wang Ye Jin Xiang-Mei Wen Ji-Chun Ma Li-Juan Tang Zhen-Wei Mao Jun Qian Jiang Lin The M2 macrophage marker CD206: a novel prognostic indicator for acute myeloid leukemia OncoImmunology cd206 m2 macrophage acute myeloid leukemia prognosis |
author_facet |
Zi-Jun Xu Yu Gu Cui-Zhu Wang Ye Jin Xiang-Mei Wen Ji-Chun Ma Li-Juan Tang Zhen-Wei Mao Jun Qian Jiang Lin |
author_sort |
Zi-Jun Xu |
title |
The M2 macrophage marker CD206: a novel prognostic indicator for acute myeloid leukemia |
title_short |
The M2 macrophage marker CD206: a novel prognostic indicator for acute myeloid leukemia |
title_full |
The M2 macrophage marker CD206: a novel prognostic indicator for acute myeloid leukemia |
title_fullStr |
The M2 macrophage marker CD206: a novel prognostic indicator for acute myeloid leukemia |
title_full_unstemmed |
The M2 macrophage marker CD206: a novel prognostic indicator for acute myeloid leukemia |
title_sort |
m2 macrophage marker cd206: a novel prognostic indicator for acute myeloid leukemia |
publisher |
Taylor & Francis Group |
series |
OncoImmunology |
issn |
2162-402X |
publishDate |
2020-01-01 |
description |
Hematological malignancies possess a distinctive immunologic microenvironment compared with solid tumors. Here, using an established computational algorithm (CIBERSORT), we systematically analyzed the overall distribution of 22 tumor-infiltrating leukocyte (TIL) populations in more than 2000 bone marrow (BM) samples from 5 major hematological malignancies and healthy controls. Focusing on significantly altered TILs in acute myeloid leukemia (AML), we found that patients with AML exhibited increased frequencies of M2 macrophages, compared to either healthy controls or the other four malignancies. High infiltration of M2 macrophages was associated with poor outcome in AML. Further analysis revealed that CD206, a M2 marker gene, could faithfully reflect variation in M2 fractions and was more highly expressed in AML than normal controls. High CD206 expression predicted inferior overall survival (OS) and event-free survival (EFS) in two independent AML cohorts. Among 175 patients with intermediate-risk cytogenetics, the survival still differed greatly between low and high CD206 expressers (OS; P < .0001; 3-year rates, 56% v 32%; EFS; P < .001; 3-year rates, 47% v 25%). When analyzed in a meta-analysis, CD206 as a continuous variable showed superior predictive performance than classical prognosticators in AML (BAALC, ERG, EVI1, MN1, and WT1). In summary, M2 macrophages are preferentially enriched in AML. The M2 marker CD206 may serve as a new prognostic marker in AML. |
topic |
cd206 m2 macrophage acute myeloid leukemia prognosis |
url |
http://dx.doi.org/10.1080/2162402X.2019.1683347 |
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