Relating the chondrocyte gene network to growth plate morphology: from genes to phenotype.

Relating the chondrocyte gene network to growth plate morphology: from genes to phenotype.

During endochondral ossification, chondrocyte growth and differentiation is controlled by many local signalling pathways. Due to crosstalks and feedback mechanisms, these interwoven pathways display a network like structure. In this study, a large-scale literature based logical model of the growth p...

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Main Authors: Johan Kerkhofs, Scott J Roberts, Frank P Luyten, Hans Van Oosterwyck, Liesbet Geris
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22558096/?tool=EBI
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spelling doaj-3587aac68a6c42ef9fc3ed50a70e86002021-03-03T20:29:22ZengPublic Library of Science (PLoS)PLoS ONE1932-62032012-01-0174e3472910.1371/journal.pone.0034729Relating the chondrocyte gene network to growth plate morphology: from genes to phenotype.Johan KerkhofsScott J RobertsFrank P LuytenHans Van OosterwyckLiesbet GerisDuring endochondral ossification, chondrocyte growth and differentiation is controlled by many local signalling pathways. Due to crosstalks and feedback mechanisms, these interwoven pathways display a network like structure. In this study, a large-scale literature based logical model of the growth plate network was developed. The network is able to capture the different states (resting, proliferating and hypertrophic) that chondrocytes go through as they progress within the growth plate. In a first corroboration step, the effect of mutations in various signalling pathways of the growth plate network was investigated.https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22558096/?tool=EBI
collection DOAJ
language English
format Article
sources DOAJ
author Johan Kerkhofs
Scott J Roberts
Frank P Luyten
Hans Van Oosterwyck
Liesbet Geris
spellingShingle Johan Kerkhofs
Scott J Roberts
Frank P Luyten
Hans Van Oosterwyck
Liesbet Geris
Relating the chondrocyte gene network to growth plate morphology: from genes to phenotype.
PLoS ONE
author_facet Johan Kerkhofs
Scott J Roberts
Frank P Luyten
Hans Van Oosterwyck
Liesbet Geris
author_sort Johan Kerkhofs
title Relating the chondrocyte gene network to growth plate morphology: from genes to phenotype.
title_short Relating the chondrocyte gene network to growth plate morphology: from genes to phenotype.
title_full Relating the chondrocyte gene network to growth plate morphology: from genes to phenotype.
title_fullStr Relating the chondrocyte gene network to growth plate morphology: from genes to phenotype.
title_full_unstemmed Relating the chondrocyte gene network to growth plate morphology: from genes to phenotype.
title_sort relating the chondrocyte gene network to growth plate morphology: from genes to phenotype.
publisher Public Library of Science (PLoS)
series PLoS ONE
issn 1932-6203
publishDate 2012-01-01
description During endochondral ossification, chondrocyte growth and differentiation is controlled by many local signalling pathways. Due to crosstalks and feedback mechanisms, these interwoven pathways display a network like structure. In this study, a large-scale literature based logical model of the growth plate network was developed. The network is able to capture the different states (resting, proliferating and hypertrophic) that chondrocytes go through as they progress within the growth plate. In a first corroboration step, the effect of mutations in various signalling pathways of the growth plate network was investigated.
url https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22558096/?tool=EBI
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AT frankpluyten relatingthechondrocytegenenetworktogrowthplatemorphologyfromgenestophenotype
AT hansvanoosterwyck relatingthechondrocytegenenetworktogrowthplatemorphologyfromgenestophenotype
AT liesbetgeris relatingthechondrocytegenenetworktogrowthplatemorphologyfromgenestophenotype
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