IL-33-mediated mast cell activation promotes gastric cancer through macrophage mobilization

Mast cells within the tumor microenvironment have controversial roles. Here, the authors show, using genetic mouse models, that in gastric cancer, mast cells at the periphery of the tumors are activated via cancer cell produced-IL33 and promote tumorigenesis by recruiting macrophages within the tumo...

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Main Authors:	Moritz F. Eissmann, Christine Dijkstra, Andrew Jarnicki, Toby Phesse, Jamina Brunnberg, Ashleigh R. Poh, Nima Etemadi, Evelyn Tsantikos, Stefan Thiem, Nicholas D. Huntington, Margaret L. Hibbs, Alex Boussioutas, Michele A. Grimbaldeston, Michael Buchert, Robert J. J. O’Donoghue, Frederick Masson, Matthias Ernst
Format:	Article
Language:	English
Published:	Nature Publishing Group 2019-06-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-019-10676-1

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spelling	doaj-358dfe59c0ac41659d29059d99a2f0be2021-05-11T11:59:08ZengNature Publishing GroupNature Communications2041-17232019-06-0110111610.1038/s41467-019-10676-1IL-33-mediated mast cell activation promotes gastric cancer through macrophage mobilizationMoritz F. Eissmann0Christine Dijkstra1Andrew Jarnicki2Toby Phesse3Jamina Brunnberg4Ashleigh R. Poh5Nima Etemadi6Evelyn Tsantikos7Stefan Thiem8Nicholas D. Huntington9Margaret L. Hibbs10Alex Boussioutas11Michele A. Grimbaldeston12Michael Buchert13Robert J. J. O’Donoghue14Frederick Masson15Matthias Ernst16Cancer and Inflammation Laboratory, Olivia Newton-John Cancer Research Institute and School of Cancer Medicine, La Trobe UniversityCancer and Inflammation Laboratory, Olivia Newton-John Cancer Research Institute and School of Cancer Medicine, La Trobe UniversityDepartment of Pharmacology and Therapeutics, University of MelbourneCancer and Inflammation Laboratory, Olivia Newton-John Cancer Research Institute and School of Cancer Medicine, La Trobe UniversityCancer and Inflammation Laboratory, Olivia Newton-John Cancer Research Institute and School of Cancer Medicine, La Trobe UniversityCancer and Inflammation Laboratory, Olivia Newton-John Cancer Research Institute and School of Cancer Medicine, La Trobe UniversityCancer and Inflammation Laboratory, Olivia Newton-John Cancer Research Institute and School of Cancer Medicine, La Trobe UniversityDepartment of Immunology and Pathology, Monash UniversityCancer and Inflammation Laboratory, Olivia Newton-John Cancer Research Institute and School of Cancer Medicine, La Trobe UniversityMolecular Immunology Division, The Walter and Eliza Hall Institute of Medical Research, and Department of Medical Biology, University of MelbourneDepartment of Immunology and Pathology, Monash UniversityDepartment of Medicine, University of MelbourneCentre for Cancer Biology, University of South Australia and SA PathologyCancer and Inflammation Laboratory, Olivia Newton-John Cancer Research Institute and School of Cancer Medicine, La Trobe UniversityCancer and Inflammation Laboratory, Olivia Newton-John Cancer Research Institute and School of Cancer Medicine, La Trobe UniversityCancer and Inflammation Laboratory, Olivia Newton-John Cancer Research Institute and School of Cancer Medicine, La Trobe UniversityCancer and Inflammation Laboratory, Olivia Newton-John Cancer Research Institute and School of Cancer Medicine, La Trobe UniversityMast cells within the tumor microenvironment have controversial roles. Here, the authors show, using genetic mouse models, that in gastric cancer, mast cells at the periphery of the tumors are activated via cancer cell produced-IL33 and promote tumorigenesis by recruiting macrophages within the tumors.https://doi.org/10.1038/s41467-019-10676-1
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Moritz F. Eissmann Christine Dijkstra Andrew Jarnicki Toby Phesse Jamina Brunnberg Ashleigh R. Poh Nima Etemadi Evelyn Tsantikos Stefan Thiem Nicholas D. Huntington Margaret L. Hibbs Alex Boussioutas Michele A. Grimbaldeston Michael Buchert Robert J. J. O’Donoghue Frederick Masson Matthias Ernst
spellingShingle	Moritz F. Eissmann Christine Dijkstra Andrew Jarnicki Toby Phesse Jamina Brunnberg Ashleigh R. Poh Nima Etemadi Evelyn Tsantikos Stefan Thiem Nicholas D. Huntington Margaret L. Hibbs Alex Boussioutas Michele A. Grimbaldeston Michael Buchert Robert J. J. O’Donoghue Frederick Masson Matthias Ernst IL-33-mediated mast cell activation promotes gastric cancer through macrophage mobilization Nature Communications
author_facet	Moritz F. Eissmann Christine Dijkstra Andrew Jarnicki Toby Phesse Jamina Brunnberg Ashleigh R. Poh Nima Etemadi Evelyn Tsantikos Stefan Thiem Nicholas D. Huntington Margaret L. Hibbs Alex Boussioutas Michele A. Grimbaldeston Michael Buchert Robert J. J. O’Donoghue Frederick Masson Matthias Ernst
author_sort	Moritz F. Eissmann
title	IL-33-mediated mast cell activation promotes gastric cancer through macrophage mobilization
title_short	IL-33-mediated mast cell activation promotes gastric cancer through macrophage mobilization
title_full	IL-33-mediated mast cell activation promotes gastric cancer through macrophage mobilization
title_fullStr	IL-33-mediated mast cell activation promotes gastric cancer through macrophage mobilization
title_full_unstemmed	IL-33-mediated mast cell activation promotes gastric cancer through macrophage mobilization
title_sort	il-33-mediated mast cell activation promotes gastric cancer through macrophage mobilization
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2019-06-01
description	Mast cells within the tumor microenvironment have controversial roles. Here, the authors show, using genetic mouse models, that in gastric cancer, mast cells at the periphery of the tumors are activated via cancer cell produced-IL33 and promote tumorigenesis by recruiting macrophages within the tumors.
url	https://doi.org/10.1038/s41467-019-10676-1
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IL-33-mediated mast cell activation promotes gastric cancer through macrophage mobilization

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