Carcinoma Arising from Brunner’s Gland in the Duodenum after 17 Years of Observation – A Case Report and Literature Review
A 60-year-old man presented with melena and hematemesis in 1984. Esophagogastroduodenoscopy (EGD) detected a small protruding lesion in the duodenal bulb, which was diagnosed as Brunner’s adenoma. No significant change was detected in subsequent annual EGD and biopsies for 10 years, after which the...
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2007-10-01
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doaj-35a4bb191303409fa7c7ee35289b0a9c2020-11-24T23:44:24ZengKarger PublishersCase Reports in Gastroenterology1662-06312007-10-011110310910.1159/000108944108944Carcinoma Arising from Brunner’s Gland in the Duodenum after 17 Years of Observation – A Case Report and Literature ReviewMasaru KoizumiNaohiro SataKoji YoshizawaKatsumi KuriharaYoshikazu YasudaA 60-year-old man presented with melena and hematemesis in 1984. Esophagogastroduodenoscopy (EGD) detected a small protruding lesion in the duodenal bulb, which was diagnosed as Brunner’s adenoma. No significant change was detected in subsequent annual EGD and biopsies for 10 years, after which the patient was not observed for 7 years. The patient presented with melena again in 2001. The lesion had changed shape to become a 10 mm sessile tumor with a central depression, and following a biopsy was diagnosed as an adenocarcinoma. The patient underwent partial resection of the duodenum. Histopathological assessment showed acidophilic cells with swollen nuclei, and clear cells forming a tubular or papillary tubule in the mucosal lamina propria and submucosal layer. The tumor cells stained positive for lysozyme, indicating that they arose from Brunner’s gland. The patient showed no sign of recurrence and was disease-free for more than 34 months after surgery. The patient died of pneumonia. This is an extremely rare case of primary duodenal carcinoma arising from Brunner’s gland in a patient observed for 17 years.http://www.karger.comArticle/FullText/108944Duodenal cancerBrunner’s glandAdenocarcinoma |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Masaru Koizumi Naohiro Sata Koji Yoshizawa Katsumi Kurihara Yoshikazu Yasuda |
spellingShingle |
Masaru Koizumi Naohiro Sata Koji Yoshizawa Katsumi Kurihara Yoshikazu Yasuda Carcinoma Arising from Brunner’s Gland in the Duodenum after 17 Years of Observation – A Case Report and Literature Review Case Reports in Gastroenterology Duodenal cancer Brunner’s gland Adenocarcinoma |
author_facet |
Masaru Koizumi Naohiro Sata Koji Yoshizawa Katsumi Kurihara Yoshikazu Yasuda |
author_sort |
Masaru Koizumi |
title |
Carcinoma Arising from Brunner’s Gland in the Duodenum after 17 Years of Observation – A Case Report and Literature Review |
title_short |
Carcinoma Arising from Brunner’s Gland in the Duodenum after 17 Years of Observation – A Case Report and Literature Review |
title_full |
Carcinoma Arising from Brunner’s Gland in the Duodenum after 17 Years of Observation – A Case Report and Literature Review |
title_fullStr |
Carcinoma Arising from Brunner’s Gland in the Duodenum after 17 Years of Observation – A Case Report and Literature Review |
title_full_unstemmed |
Carcinoma Arising from Brunner’s Gland in the Duodenum after 17 Years of Observation – A Case Report and Literature Review |
title_sort |
carcinoma arising from brunner’s gland in the duodenum after 17 years of observation – a case report and literature review |
publisher |
Karger Publishers |
series |
Case Reports in Gastroenterology |
issn |
1662-0631 |
publishDate |
2007-10-01 |
description |
A 60-year-old man presented with melena and hematemesis in 1984. Esophagogastroduodenoscopy (EGD) detected a small protruding lesion in the duodenal bulb, which was diagnosed as Brunner’s adenoma. No significant change was detected in subsequent annual EGD and biopsies for 10 years, after which the patient was not observed for 7 years. The patient presented with melena again in 2001. The lesion had changed shape to become a 10 mm sessile tumor with a central depression, and following a biopsy was diagnosed as an adenocarcinoma. The patient underwent partial resection of the duodenum. Histopathological assessment showed acidophilic cells with swollen nuclei, and clear cells forming a tubular or papillary tubule in the mucosal lamina propria and submucosal layer. The tumor cells stained positive for lysozyme, indicating that they arose from Brunner’s gland. The patient showed no sign of recurrence and was disease-free for more than 34 months after surgery. The patient died of pneumonia. This is an extremely rare case of primary duodenal carcinoma arising from Brunner’s gland in a patient observed for 17 years. |
topic |
Duodenal cancer Brunner’s gland Adenocarcinoma |
url |
http://www.karger.comArticle/FullText/108944 |
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