Is there any association between contrast-induced nephropathy and serum uric acid levels?
Introduction: During the recent years, several studies have investigated that hyperuricemia is associated with greater incidence of contrast induced nephropathy (CIN). Most of them are in acute conditions like primary percutaneous coronary interventions. This study aimed to assess the relationship b...
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Tabriz University of Medical Sciences
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doaj-35a51860e6004ac7bcb5619b83deb2072021-06-23T10:29:20ZengTabriz University of Medical SciencesJournal of Cardiovascular and Thoracic Research2008-51172008-68302021-02-01131616710.34172/jcvtr.2021.20jcvtr-29012Is there any association between contrast-induced nephropathy and serum uric acid levels?Fardin Mirbolouk0Samira Arami1Mahboobe Gholipour2Yasaman Khalili3Seyedeh Shiva Modallalkar4Mona Naghshbandi5Cardiovascular Diseases Research Center, Department of Cardiology, Heshmat Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, IranCardiovascular Diseases Research Center, Department of Cardiology, Heshmat Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, IranCardiovascular Diseases Research Center, Department of Cardiology, Heshmat Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, IranRajaei Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, IranCardiovascular Diseases Research Center, Department of Cardiology, Heshmat Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, IranCardiovascular Diseases Research Center, Department of Cardiology, Heshmat Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, IranIntroduction: During the recent years, several studies have investigated that hyperuricemia is associated with greater incidence of contrast induced nephropathy (CIN). Most of them are in acute conditions like primary percutaneous coronary interventions. This study aimed to assess the relationship between high serum uric acid and incidence of acute kidney injury in patients undergoing elective angiography and angioplasty. Methods: This prospective study was conducted on 211 patients who were admitted to hospital for elective coronary angiography or angioplasty. The researchers measured serum creatinine and uric acid on admission and repeated creatinine measurement in 48 hours and seven days after the procedure. According to serum uric acid, the patients were divided into two groups; group 1 with normal uric acid and group 2 with hyperuricemia which was defined as uric acid more than 6 mg/dL in women and 7 mg/dL in men. CIN is defined as an increased creatinine level of more than 0.5 mg/dL or 25% from the baseline in 48 hours after the intervention. Results: In total, 211 patients with mean age of 60.58 years were enrolled in the study. Of these, 87 (41.2%) patients were in the high uric acid group and 124 (58.8%) were in the normal uric acid group. CIN was occurred in 16 patients (7.5%). Seven out of 16 (8.04%) were in the high uric acid and nine (7.2%) were in the normal uric acid group. There were no significant differences between the two groups (P =0.831). Conclusion: The frequency of CIN development was not different in the patients with hyperuricemia.https://jcvtr.tbzmed.ac.ir/PDF/jcvtr-13-61.pdfuric acidhyperuricemiaacute kidney injurycontrast nephropathy |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Fardin Mirbolouk Samira Arami Mahboobe Gholipour Yasaman Khalili Seyedeh Shiva Modallalkar Mona Naghshbandi |
spellingShingle |
Fardin Mirbolouk Samira Arami Mahboobe Gholipour Yasaman Khalili Seyedeh Shiva Modallalkar Mona Naghshbandi Is there any association between contrast-induced nephropathy and serum uric acid levels? Journal of Cardiovascular and Thoracic Research uric acid hyperuricemia acute kidney injury contrast nephropathy |
author_facet |
Fardin Mirbolouk Samira Arami Mahboobe Gholipour Yasaman Khalili Seyedeh Shiva Modallalkar Mona Naghshbandi |
author_sort |
Fardin Mirbolouk |
title |
Is there any association between contrast-induced nephropathy and serum uric acid levels? |
title_short |
Is there any association between contrast-induced nephropathy and serum uric acid levels? |
title_full |
Is there any association between contrast-induced nephropathy and serum uric acid levels? |
title_fullStr |
Is there any association between contrast-induced nephropathy and serum uric acid levels? |
title_full_unstemmed |
Is there any association between contrast-induced nephropathy and serum uric acid levels? |
title_sort |
is there any association between contrast-induced nephropathy and serum uric acid levels? |
publisher |
Tabriz University of Medical Sciences |
series |
Journal of Cardiovascular and Thoracic Research |
issn |
2008-5117 2008-6830 |
publishDate |
2021-02-01 |
description |
Introduction: During the recent years, several studies have investigated that hyperuricemia is associated with greater incidence of contrast induced nephropathy (CIN). Most of them are in acute conditions like primary percutaneous coronary interventions. This study aimed to assess the relationship between high serum uric acid and incidence of acute kidney injury in patients undergoing elective angiography and angioplasty. Methods: This prospective study was conducted on 211 patients who were admitted to hospital for elective coronary angiography or angioplasty. The researchers measured serum creatinine and uric acid on admission and repeated creatinine measurement in 48 hours and seven days after the procedure. According to serum uric acid, the patients were divided into two groups; group 1 with normal uric acid and group 2 with hyperuricemia which was defined as uric acid more than 6 mg/dL in women and 7 mg/dL in men. CIN is defined as an increased creatinine level of more than 0.5 mg/dL or 25% from the baseline in 48 hours after the intervention. Results: In total, 211 patients with mean age of 60.58 years were enrolled in the study. Of these, 87 (41.2%) patients were in the high uric acid group and 124 (58.8%) were in the normal uric acid group. CIN was occurred in 16 patients (7.5%). Seven out of 16 (8.04%) were in the high uric acid and nine (7.2%) were in the normal uric acid group. There were no significant differences between the two groups (P =0.831). Conclusion: The frequency of CIN development was not different in the patients with hyperuricemia. |
topic |
uric acid hyperuricemia acute kidney injury contrast nephropathy |
url |
https://jcvtr.tbzmed.ac.ir/PDF/jcvtr-13-61.pdf |
work_keys_str_mv |
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