Structural Bases for the Synergistic Inhibition of Human Thymidylate Synthase and Ovarian Cancer Cell Growth by Drug Combinations

Structural Bases for the Synergistic Inhibition of Human Thymidylate Synthase and Ovarian Cancer Cell Growth by Drug Combinations

Combining drugs represent an approach to efficiently prevent and overcome drug resistance and to reduce toxicity; yet it is a highly challenging task, particularly if combinations of inhibitors of the same enzyme target are considered. To show that crystallographic and inhibition kinetic information...

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Bibliographic Details
Main Authors: Cecilia Pozzi, Matteo Santucci, Gaetano Marverti, Domenico D’Arca, Lorenzo Tagliazucchi, Stefania Ferrari, Gaia Gozzi, Lorena Losi, Giusy Tassone, Stefano Mangani, Glauco Ponterini, Maria Paola Costi
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Cancers
Subjects:
drug combinations
thymidylate synthase
X-ray crystal structures
inhibition kinetics
anticancer agents
synergistic combination
Online Access:https://www.mdpi.com/2072-6694/13/9/2061

Internet

https://www.mdpi.com/2072-6694/13/9/2061

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