Feasibility of Wave Intensity Analysis in Patients With Conotruncal Anomalies Before and After Pregnancy: New Physiological Insights?
Background: Conotruncal anomalies (CTA) are associated with ongoing dilation of the aortic root, as well as increased aortic stiffness, which may relate to intrinsic properties of the aorta. Pregnancy hormones lead to hemodynamic changes and remodeling of the tunica media, resulting in the opposite...
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doaj-35a76bec72384743a29d4ec936a1a8842021-03-04T04:24:50ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602021-03-01810.3389/fped.2020.557407557407Feasibility of Wave Intensity Analysis in Patients With Conotruncal Anomalies Before and After Pregnancy: New Physiological Insights?Maria Victoria Ordonez0Maria Victoria Ordonez1Sandra Neumann2Massimo Caputo3Massimo Caputo4Stephanie Curtis5Giovanni Biglino6Giovanni Biglino7Giovanni Biglino8Bristol Heart Institute, University Hospitals Bristol, Bristol, United KingdomBristol Medical School, University of Bristol, Bristol, United KingdomBristol Medical School, University of Bristol, Bristol, United KingdomBristol Heart Institute, University Hospitals Bristol, Bristol, United KingdomBristol Medical School, University of Bristol, Bristol, United KingdomBristol Heart Institute, University Hospitals Bristol, Bristol, United KingdomBristol Heart Institute, University Hospitals Bristol, Bristol, United KingdomBristol Medical School, University of Bristol, Bristol, United KingdomNational Heart and Lung Institute, Imperial College London, London, United KingdomBackground: Conotruncal anomalies (CTA) are associated with ongoing dilation of the aortic root, as well as increased aortic stiffness, which may relate to intrinsic properties of the aorta. Pregnancy hormones lead to hemodynamic changes and remodeling of the tunica media, resulting in the opposite effect, i.e., increasing distensibility. These changes normalize post-pregnancy in healthy women but have not been fully investigated in CTA patients.Methods: We examined aortic distensibility and ventriculo-arterial coupling before and after pregnancy using cardiovascular magnetic resonance (CMR)-derived wave intensity analysis (WIA). Pre- and post-pregnancy CMR data were retrospectively analyzed. Aortic diameters were measured before, during, and after pregnancy by cardiac ultrasound and before and after pregnancy by CMR. Phase contrast MR flow sequences were used for calculating wave speed (c) and intensity (WI). A matched analysis was performed comparing results before and after pregnancy.Results: Thirteen women (n = 5, transposition of the great arteries; n = 6, tetralogy of Fallot; n = 1, double outlet right ventricle, n = 1, truncus arteriosus) had 19 pregnancies. Median time between delivery and second CMR was 2.3 years (range: 1–6 years). The aortic diameter increased significantly after pregnancy in nine (n = 9) patients by a median of 4 ± 2.3 mm (range: 2–7.0 mm, p = 0.01). There was no difference in c pre-/post-pregnancy (p = 0.73), suggesting that increased compliance, typically observed during pregnancy, does not persist long term. A significant inverse relationship was observed between c and heart rate (HR) after pregnancy (p = 0.01, r = 0.73). There was no significant difference in cardiac output, aortic/pulmonary regurgitation, or WI peaks pre-/post-pregnancy.Conclusions: WIA is feasible in this population and could provide physiological insights in larger cohorts. Aortic distensibility and wave intensity did not change before and after pregnancy in CTA patients, despite an increase in diameter, suggesting that pregnancy did not adversely affect coupling in the long-term.https://www.frontiersin.org/articles/10.3389/fped.2020.557407/fullconotruncal anomaliespregnancyaorta distensibilityaorta diameterwave intensity analysis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Maria Victoria Ordonez Maria Victoria Ordonez Sandra Neumann Massimo Caputo Massimo Caputo Stephanie Curtis Giovanni Biglino Giovanni Biglino Giovanni Biglino |
spellingShingle |
Maria Victoria Ordonez Maria Victoria Ordonez Sandra Neumann Massimo Caputo Massimo Caputo Stephanie Curtis Giovanni Biglino Giovanni Biglino Giovanni Biglino Feasibility of Wave Intensity Analysis in Patients With Conotruncal Anomalies Before and After Pregnancy: New Physiological Insights? Frontiers in Pediatrics conotruncal anomalies pregnancy aorta distensibility aorta diameter wave intensity analysis |
author_facet |
Maria Victoria Ordonez Maria Victoria Ordonez Sandra Neumann Massimo Caputo Massimo Caputo Stephanie Curtis Giovanni Biglino Giovanni Biglino Giovanni Biglino |
author_sort |
Maria Victoria Ordonez |
title |
Feasibility of Wave Intensity Analysis in Patients With Conotruncal Anomalies Before and After Pregnancy: New Physiological Insights? |
title_short |
Feasibility of Wave Intensity Analysis in Patients With Conotruncal Anomalies Before and After Pregnancy: New Physiological Insights? |
title_full |
Feasibility of Wave Intensity Analysis in Patients With Conotruncal Anomalies Before and After Pregnancy: New Physiological Insights? |
title_fullStr |
Feasibility of Wave Intensity Analysis in Patients With Conotruncal Anomalies Before and After Pregnancy: New Physiological Insights? |
title_full_unstemmed |
Feasibility of Wave Intensity Analysis in Patients With Conotruncal Anomalies Before and After Pregnancy: New Physiological Insights? |
title_sort |
feasibility of wave intensity analysis in patients with conotruncal anomalies before and after pregnancy: new physiological insights? |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Pediatrics |
issn |
2296-2360 |
publishDate |
2021-03-01 |
description |
Background: Conotruncal anomalies (CTA) are associated with ongoing dilation of the aortic root, as well as increased aortic stiffness, which may relate to intrinsic properties of the aorta. Pregnancy hormones lead to hemodynamic changes and remodeling of the tunica media, resulting in the opposite effect, i.e., increasing distensibility. These changes normalize post-pregnancy in healthy women but have not been fully investigated in CTA patients.Methods: We examined aortic distensibility and ventriculo-arterial coupling before and after pregnancy using cardiovascular magnetic resonance (CMR)-derived wave intensity analysis (WIA). Pre- and post-pregnancy CMR data were retrospectively analyzed. Aortic diameters were measured before, during, and after pregnancy by cardiac ultrasound and before and after pregnancy by CMR. Phase contrast MR flow sequences were used for calculating wave speed (c) and intensity (WI). A matched analysis was performed comparing results before and after pregnancy.Results: Thirteen women (n = 5, transposition of the great arteries; n = 6, tetralogy of Fallot; n = 1, double outlet right ventricle, n = 1, truncus arteriosus) had 19 pregnancies. Median time between delivery and second CMR was 2.3 years (range: 1–6 years). The aortic diameter increased significantly after pregnancy in nine (n = 9) patients by a median of 4 ± 2.3 mm (range: 2–7.0 mm, p = 0.01). There was no difference in c pre-/post-pregnancy (p = 0.73), suggesting that increased compliance, typically observed during pregnancy, does not persist long term. A significant inverse relationship was observed between c and heart rate (HR) after pregnancy (p = 0.01, r = 0.73). There was no significant difference in cardiac output, aortic/pulmonary regurgitation, or WI peaks pre-/post-pregnancy.Conclusions: WIA is feasible in this population and could provide physiological insights in larger cohorts. Aortic distensibility and wave intensity did not change before and after pregnancy in CTA patients, despite an increase in diameter, suggesting that pregnancy did not adversely affect coupling in the long-term. |
topic |
conotruncal anomalies pregnancy aorta distensibility aorta diameter wave intensity analysis |
url |
https://www.frontiersin.org/articles/10.3389/fped.2020.557407/full |
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