Mesenchymal Stem Cell-Mediated Effects of Tumor Support or Suppression
Mesenchymal stem cells (MSCs) can exhibit a marked tropism towards site of tumors. Many studies have reported that tumor progression and metastasis increase by MSCs. In contrast, other studies have shown that MSCs suppress growth of tumors. MSCs contribute to tumor growth promotion by several mechan...
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doaj-35a8d7bf41284917a91c55456cd6009b2020-11-25T00:54:55ZengMDPI AGInternational Journal of Molecular Sciences1422-00672015-12-011612300153003310.3390/ijms161226215ijms161226215Mesenchymal Stem Cell-Mediated Effects of Tumor Support or SuppressionKi-Jong Rhee0Jong In Lee1Young Woo Eom2Department of Biomedical Laboratory Science, College of Health Sciences, Yonsei University, 1 Yonseidae-gil, Wonju 26493, KoreaDepartment of Hematology-Oncology, Wonju College of Medicine, Yonsei University, 20 Ilsan-ro, Wonju 26426, KoreaCell Therapy and Tissue Engineering Center, Wonju College of Medicine, Yonsei University, 20 Ilsan-ro, Wonju 26426, KoreaMesenchymal stem cells (MSCs) can exhibit a marked tropism towards site of tumors. Many studies have reported that tumor progression and metastasis increase by MSCs. In contrast, other studies have shown that MSCs suppress growth of tumors. MSCs contribute to tumor growth promotion by several mechanisms: (1) transition to tumor-associated fibroblasts; (2) suppression of immune response; (3) promotion of angiogenesis; (4) stimulation of epithelial-mesenchymal transition (EMT); (5) contribution to the tumor microenvironment; (6) inhibition of tumor cell apoptosis; and (7) promotion of tumor metastasis. In contrast to the tumor-promoting properties, MSCs inhibit tumor growth by increasing inflammatory infiltration, inhibiting angiogenesis, suppressing Wnt signaling and AKT signaling, and inducing cell cycle arrest and apoptosis. In this review, we will discuss potential mechanisms by which MSC mediates tumor support or suppression and then the possible tumor-specific therapeutic strategies using MSCs as delivery vehicles, based on their homing potential to tumors.http://www.mdpi.com/1422-0067/16/12/26215mesenchymal stem cellstumor microenvironmenthomingdelivery vehicles |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ki-Jong Rhee Jong In Lee Young Woo Eom |
spellingShingle |
Ki-Jong Rhee Jong In Lee Young Woo Eom Mesenchymal Stem Cell-Mediated Effects of Tumor Support or Suppression International Journal of Molecular Sciences mesenchymal stem cells tumor microenvironment homing delivery vehicles |
author_facet |
Ki-Jong Rhee Jong In Lee Young Woo Eom |
author_sort |
Ki-Jong Rhee |
title |
Mesenchymal Stem Cell-Mediated Effects of Tumor Support or Suppression |
title_short |
Mesenchymal Stem Cell-Mediated Effects of Tumor Support or Suppression |
title_full |
Mesenchymal Stem Cell-Mediated Effects of Tumor Support or Suppression |
title_fullStr |
Mesenchymal Stem Cell-Mediated Effects of Tumor Support or Suppression |
title_full_unstemmed |
Mesenchymal Stem Cell-Mediated Effects of Tumor Support or Suppression |
title_sort |
mesenchymal stem cell-mediated effects of tumor support or suppression |
publisher |
MDPI AG |
series |
International Journal of Molecular Sciences |
issn |
1422-0067 |
publishDate |
2015-12-01 |
description |
Mesenchymal stem cells (MSCs) can exhibit a marked tropism towards site of tumors. Many studies have reported that tumor progression and metastasis increase by MSCs. In contrast, other studies have shown that MSCs suppress growth of tumors. MSCs contribute to tumor growth promotion by several mechanisms: (1) transition to tumor-associated fibroblasts; (2) suppression of immune response; (3) promotion of angiogenesis; (4) stimulation of epithelial-mesenchymal transition (EMT); (5) contribution to the tumor microenvironment; (6) inhibition of tumor cell apoptosis; and (7) promotion of tumor metastasis. In contrast to the tumor-promoting properties, MSCs inhibit tumor growth by increasing inflammatory infiltration, inhibiting angiogenesis, suppressing Wnt signaling and AKT signaling, and inducing cell cycle arrest and apoptosis. In this review, we will discuss potential mechanisms by which MSC mediates tumor support or suppression and then the possible tumor-specific therapeutic strategies using MSCs as delivery vehicles, based on their homing potential to tumors. |
topic |
mesenchymal stem cells tumor microenvironment homing delivery vehicles |
url |
http://www.mdpi.com/1422-0067/16/12/26215 |
work_keys_str_mv |
AT kijongrhee mesenchymalstemcellmediatedeffectsoftumorsupportorsuppression AT jonginlee mesenchymalstemcellmediatedeffectsoftumorsupportorsuppression AT youngwooeom mesenchymalstemcellmediatedeffectsoftumorsupportorsuppression |
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